This is an observational registry to assess the clinical utility of surveillance using HeartCare testing services, in association with clinical care of heart transplant recipients.
Description
HeartCare is a service which includes AlloMap® and AlloSure-Heart® to provide information to help clinicians to more comprehensively monitor heart transplant recipients for allograft rejection. An approach to surveillance using HeartCare provides information from two complementary measures; AlloMap is a gene-expression profile based measure of host immune activity and risk of acute rejection. AlloSure-Heart monitors graft injury. AlloMap is the first FDA cleared test and is the only non-invasive, blood test method recommended in the International Society for Heart and Lung Transplantation (ISHLT) guidelines for surveillance of heart transplant recipients for rejection. AlloSure-Heart measures donor-derived cell-free DNA (dd-cfDNA) to help discriminate acute cellular rejection and antibody-mediated rejection from no rejection. Patients who receive HeartCare, as part of their post-transplant management, will give informed consent for information on their outcomes and other relevant clinical information, found in their medical records, to be entered into a SHORE database for purposes of the study.
Who can participate
Inclusion Criteria:
1. Patients who are 15 years of age or older at the time of blood draw.
2. Received a heart transplant (primary or repeat)
3. Patients who have HeartCare initiated within 3 months post-transplant
Exclusion Criteria:
1\. Patients who are pregnant at the time of blood draw.
Interventions
Standard of Care
OTHER
Locations
67
United States (67)
Piedmont Heart Institute
Atlanta , Georgia
Ascension Seton
Austin , Texas
Tufts Medical Center
Boston , Massachusetts
Massachusetts General Hospital
Boston , Massachusetts
University of North Carolina at Chapel Hill
Chapel Hill , North Carolina
Medical University of South Carolina
Charleston , South Carolina
Northwestern University
Chicago , Illinois
University of Chicago Medicine
Chicago , Illinois
Cleveland Clinic
Cleveland , Ohio
The Ohio State University
Columbus , Ohio
Medical City Dallas
Dallas , Texas
Baylor Research Institute
Dallas , Texas
UT Southwestern Medical Center
Dallas , Texas
Henry Ford Health System
Detroit , Michigan
Inova Fairfax Medical Campus
Falls Church , Virginia
Stern Cardiovascular Foundation
Germantown , Tennessee
Spectrum Health
Grand Rapids , Michigan
Penn State Health Milton S. Hershey Medical Center
Hershey , Pennsylvania
Memorial Healthcare System
Hollywood , Florida
Baylor St. Luke's Medical Center
Houston , Texas
Houston Methodist Research Institute
Houston , Texas
UTHealth/ Memorial Hermann Hospital
Houston , Texas
Indiana University School of Medicine
Indianapolis , Indiana
Ascension St. Vincent Hospital and Health Care Center
Indianapolis , Indiana
Mayo Clinic- Florida
Jacksonville , Florida
The University of Kansas Medical Center
Kansas City , Kansas
St. Luke's Hospital of Kansas City
Kansas City , Missouri
University of California San Diego
La Jolla , California
Baptist Health Arkansas
Little Rock , Arkansas
Cedars-Sinai Medical Center
Los Angeles , California
University of California, Los Angeles
Los Angeles , California
University of Southern California
Los Angeles , California
University of Wisconsin School of Medicine and Public Health
Madison , Wisconsin
Northwell Health/ North Shore University Hospital
Manhassett , New York
Loyola University Medical Center
Maywood , Illinois
University of Miami
Miami , Florida
Medical College of Wisconsin
Milwaukee , Wisconsin
Aurora Research Institute
Milwaukee , Wisconsin
Intermountain Heart Institute
Murray , Utah
Saint Thomas Health
Nashville , Tennessee
Yale New Haven
New Haven , Connecticut
Ochsner Clinic Foundation
New Orleans , Louisiana
NYU Langone Health
New York , New York
Icahn School of Medicine at Mount Sinai
New York , New York
Columbia University Irving Medical Center
New York , New York
Sentara Cardiovascular Research Institute
Norfolk , Virginia
Advocate Christ Medical Center
Oak Lawn , Illinois
Integris Baptist Medical Center
Oklahoma City , Oklahoma
University of Nebraska Medical Center
Omaha , Nebraska
Advent Health
Orlando , Florida
University of Pennsylvania
Philadelphia , Pennsylvania
Mayo Clinic Arizona
Phoenix , Arizona
Allegheny-Singer Research Institute
Pittsburgh , Pennsylvania
University of Pittsburgh Medical Center
Pittsburgh , Pennsylvania
Oregon Health and Science University
Portland , Oregon
Mayo Clinic Rochester
Rochester , Minnesota
University of Rochester Medical Center
Rochester , New York
Methodist Healthcare Systems of San Antonio
San Antonio , Texas
California Pacific Medical Center
San Francisco , California
University of California San Fransisco Medical Center
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