Pulmonary Hemodynamics During Exercise - Research Network

The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.

Inclusion Criteria: * Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for RHC at rest and exercise * Written informed consent of participating subjects after being fully briefed (for prospective analysis) Exclusion Criteria: * Patients with incomplete hemodynamic data at rest or exercise * Patients without sufficient follow-up data (information on survival / lung transplantation) * advanced tumour disease or other diseases with a short life expectancy, except pulmonary vascular diseases * advanced heart failure with pulmonary arterial wedge pressure (PAWP) \> 18 mmHg at rest * uncontrolled systemic arterial hypertension (RR values \> 160/100 mmHg at rest) * FEV1\<50% predicted * TLC\<60% predicted