Language: BG BG
← Back to results
Active (not recruiting) Phase 1 NCT04106219

A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma

Phase 1 – testing safety in a small group of people
Conditions: Neuroblastoma

Sponsor: Eli Lilly and Company

trial.available_in: БГ
Overview
The reason for this study is to see if the study drug LY3295668 erbumine is safe in participants with relapsed/refractory neuroblastoma.
Who can participate
Inclusion Criteria: * Participants must have relapsed/refractory neuroblastoma and have active disease in at least one site: bone, bone marrow or soft tissue. Participants must be able to submit an archival sample of tissue. * Participants must be able to swallow capsules. Exclusion Criteria: * Participants must not have had an allogeneic hematopoietic stem cell, bone marrow, or solid organ transplant. * Participants must not have untreated tumor that has spread to the brain or spinal cord. * Participants must not have a serious active disease other than neuroblastoma. * Participants must not have a condition affecting absorption. * Participants must not have had prior aurora kinase inhibitor exposure. * Participants must not have a known allergy to the study treatment. * Participants must not have symptomatic human immunodeficiency virus (HIV) infection or symptomatic activated/reactivated hepatitis A, B, or C.
Interventions
LY3295668 Erbumine
DRUG
Topotecan
DRUG
Cyclophosphamide
DRUG
Locations 17
Australia (1)
Perth Children's Hospital
Perth , Western Australia
Belgium (1)
UZ Gent
Ghent , Oost-Vlaanderen
France (2)
Centre Leon Berard
Lyon , Auvergne-Rhône-Alpes
Institut Curie
Paris
Germany (1)
Universitätsklinikum Köln
Cologne
Italy (1)
Istituto Nazionale dei Tumori
Milan , Lombardy
Japan (1)
National Cancer Center Hospital
Chuo-ku , Tokyo
Spain (2)
Hospital Universitari Vall d'Hebron
Barcelona , Barcelona [Barcelona]
Hospital Infantil Universitario Niño Jesús
Madrid
United Kingdom (1)
Alder Hey Children's Hospital
Liverpool
United States (7)
Children's Hospital Colorado
Aurora , Colorado
Dana-Farber Cancer Institute
Boston , Massachusetts
University of Chicago - Comer Children's Hospital
Chicago , Illinois
Cincinnati Childrens Hospital Medical Center
Cincinnati , Ohio
Texas Childrens Hospital
Houston , Texas
Children's Hospital of Philadelphia
Philadelphia , Pennsylvania
UCSF Medical Center at Mission Bay
San Francisco , California
Technical details
Status
Active (not recruiting)
Phase
Phase 1
Study type
INTERVENTIONAL
Sex
Male and female
Minimum age
2 Years
Maximum age
21 Years
Healthy volunteers
No
Start date
11.06.2020
Completion date
01.08.2026
Registry ID
NCT04106219
Source
clinicaltrials.gov
trial.inquiry_btn

Information is automatically extracted from ClinicalTrials.gov. Consult your doctor before taking action.