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Активно (без набиране) Фаза 1 NCT04106219

A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma

Фаза 1 – тестване на безопасността при малка група хора
Заболявания: Neuroblastoma

Спонсор: Eli Lilly and Company

Налично на: БГ
Обобщение
The reason for this study is to see if the study drug LY3295668 erbumine is safe in participants with relapsed/refractory neuroblastoma.
Кой може да участва
Inclusion Criteria: * Participants must have relapsed/refractory neuroblastoma and have active disease in at least one site: bone, bone marrow or soft tissue. Participants must be able to submit an archival sample of tissue. * Participants must be able to swallow capsules. Exclusion Criteria: * Participants must not have had an allogeneic hematopoietic stem cell, bone marrow, or solid organ transplant. * Participants must not have untreated tumor that has spread to the brain or spinal cord. * Participants must not have a serious active disease other than neuroblastoma. * Participants must not have a condition affecting absorption. * Participants must not have had prior aurora kinase inhibitor exposure. * Participants must not have a known allergy to the study treatment. * Participants must not have symptomatic human immunodeficiency virus (HIV) infection or symptomatic activated/reactivated hepatitis A, B, or C.
Интервенции
LY3295668 Erbumine
DRUG
Topotecan
DRUG
Cyclophosphamide
DRUG
Места на провеждане 17
Австралия (1)
Perth Children's Hospital
Perth , Western Australia
Белгия (1)
UZ Gent
Ghent , Oost-Vlaanderen
Франция (2)
Centre Leon Berard
Lyon , Auvergne-Rhône-Alpes
Institut Curie
Paris
Германия (1)
Universitätsklinikum Köln
Cologne
Италия (1)
Istituto Nazionale dei Tumori
Milan , Lombardy
Япония (1)
National Cancer Center Hospital
Chuo-ku , Tokyo
Испания (2)
Hospital Universitari Vall d'Hebron
Barcelona , Barcelona [Barcelona]
Hospital Infantil Universitario Niño Jesús
Madrid
Великобритания (1)
Alder Hey Children's Hospital
Liverpool
САЩ (7)
Children's Hospital Colorado
Aurora , Colorado
Dana-Farber Cancer Institute
Boston , Massachusetts
University of Chicago - Comer Children's Hospital
Chicago , Illinois
Cincinnati Childrens Hospital Medical Center
Cincinnati , Ohio
Texas Childrens Hospital
Houston , Texas
Children's Hospital of Philadelphia
Philadelphia , Pennsylvania
UCSF Medical Center at Mission Bay
San Francisco , California
Технически детайли
Статус
Активно (без набиране)
Фаза
Фаза 1
Вид изследване
INTERVENTIONAL
Пол
Мъже и жени
Минимална възраст
2 Years
Максимална възраст
21 Years
Здрави доброволци
Не
Начална дата
11.06.2020
Крайна дата
01.08.2026
Регистрационен номер
NCT04106219
Източник
clinicaltrials.gov
Запитване за медицински туризъм

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