Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies
Фаза 3 – широко изпитване преди одобрение
Заболявания:
Advanced Malignancies
Спонсор: BeOne Medicines
Налично на:
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Обобщение
This is an open-label, multicenter, extension study to evaluate the long-term safety and efficacy of BeiGene or BeOne investigational drugs in participants with advanced malignancies who participated in a prior BeiGene- or BeOne-sponsored clinical study (parent study).
Описание
For the purposes of this study, "study treatment" will refer to all investigational agents. A parent study is defined as the original BeiGene- or BeOne-sponsored clinical trial in which the participant was initially enrolled and received BeiGene or BeOne investigational drugs (with or without other treatments).
Note: Our company, previously known as BeiGene, is now officially BeOne Medicines. Because some of our older studies were sponsored under the name BeiGene, you may see both names used for this study on this website.
Кой може да участва
Key Inclusion Criteria:
1. Currently participating in a BeiGene- or BeOne-sponsored eligible parent study
2. Fulfills treatment criteria specified in the parent study protocol
3. In the opinion of the investigator, the participant will continue to benefit from and tolerate any of the parent study treatments.
4. The first dose of study treatment in the LTE study will be received within the treatment interruption period allowed by the parent study:
1. "Treatment interruption" is an unplanned pause in study treatment (eg, due to adverse event). Restarting study treatment beyond the interruption period allowed by the parent study will be determined by the investigator and the sponsor.
Key Exclusion Criteria:
1. Permanently discontinued from all investigational drugs in the parent study due to unacceptable toxicity, noncompliance with study procedures, or withdrawal of consent
2. Have uncontrolled active systemic infection or recent infection requiring parenteral antimicrobial therapy prior to the start of the extension study
3. Have a medical condition or organ system dysfunction that in the investigator's opinion, could compromise the participant's safety, interfere with the absorption or metabolism of investigational drugs, or put the study outcomes at undue risk
4. Underwent treatment with any systemic anticancer treatment (other than treatment permitted in the parent study) during the time between the last treatment in the parent study and the first dose of study treatment in the LTE study
5. Pregnant or lactating women
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Интервенции
Tislelizumab
DRUG
Pamiparib
DRUG
Temozolomide
DRUG
Sitravatinib
DRUG
Ociperlimab
DRUG
BAT1706
DRUG
Fruquintinib
DRUG
BGB-15025
DRUG
Zanidatamab
DRUG
BGB-A445
DRUG
Surzebiclimab
DRUG
Lenvatinib
DRUG
LBL-007
DRUG
Места на провеждане
106
Австралия (7)
Monash Health
Clayton , Victoria
Peter Maccallum Cancer Centre
Melbourne , Victoria
Prince of Wales Hospital
Randwick , New South Wales
Icon Cancer Centre South Brisbane
South Brisbane , Queensland
Northern Cancer Institute
St Leonards , New South Wales
Calvary Mater Newcastle
Waratah , New South Wales
The Queen Elizabeth Hospital
Woodville South , South Australia
Китай (50)
Affiliated Hospital of Hebei University
Baoding , Hebei
Cancer Hospital Chinese Academy of Medical Sciences
Beijing , Beijing Municipality
Peking University First Hospital
Beijing , Beijing Municipality
The Affiliated Hospital of Military Medical Sciences
Beijing , Beijing Municipality
Beijing Cancer Hospital
Beijing , Beijing Municipality
Jilin Cancer Hospital
Changchun , Jilin
The First Hospital of Jilin University
Changchun , Jilin
Hunan Cancer Hospital
Changsha , Hunan
The First Peoples Hospital of Changzhou
Changzhou , Jiangsu
West China Hospital, Sichuan University
Chengdu , Sichuan
West China Second University Hospital, Sichuan University
Chengdu , Sichuan
Chongqing Cancer Hospital
Chongqing , Chongqing Municipality
First Affiliated Hospital of Dalian Medical University
Dalian , Liaoning
Fujian Medical University Union Hospital
Fuzhou , Fujian
Fujian Cancer Hospital
Fuzhou , Fujian
Sun Yat Sen Memorial Hospital, Sun Yat Sen University (North)
Guangzhou , Guangdong
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guangzhou , Guangdong
Guangdong Provincial Peoples Hospital
Guangzhou , Guangdong
Sun Yat Sen Memorial Hospital, Sun Yat Sen University (South)
Guangzhou , Guangdong
Nanfang Hospital of Southern Medical University
Guangzhou , Guangdong
Hainan Cancer Hospital
Haikou , Hainan
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou , Zhejiang
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou , Zhejiang
Zhejiang Cancer Hospital
Hangzhou , Zhejiang
Harbin Medical University Cancer Hospital
Harbin , Heilongjiang
The Second Hospital of Anhui Medical University
Hefei , Anhui
Shandong Cancer Hospital
Jinan , Shandong
The First Affiliated Hospital of Nanchang University Branch Donghu
Nanchang , Jiangxi
Jiangsu Province Hospital
Nanjing , Jiangsu
The Peoples Hospital of Guangxi Zhuang Autonomous Region
Nanning , Guangxi
Fudan University Shanghai Cancer Center
Shanghai , Shanghai Municipality
Shanghai Chest Hospital
Shanghai , Shanghai Municipality
Affiliated Zhongshan Hospital of Fudan University
Shanghai , Shanghai Municipality
Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai , Shanghai Municipality
Liaoning Cancer Hospital and Institute
Shenyang , Liaoning
Institute of Hematology and Hospital of Blood Disease
Tianjin , Tianjin Municipality
Tianjin Medical University Cancer Institute and Hospital
Tianjin , Tianjin Municipality
Affiliated Cancer Hospital of Xinjiang Medical University
Ürümqi , Xinjiang
Weifang Peoples Hospital
Weifang , Shandong
The First Provincial Wenzhou Hospital of Zhejiang
Wenzhou , Zhejiang
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
Wuhan , Hubei
Zhongnan Hospital of Wuhan University Wuhan
Wuhan , Hubei
Hubei Cancer Hospital
Wuhan , Hubei
The First Affiliated Hospital of Xian Jiaotong University
Xi'an , Shaanxi
The First Affiliated Hospital of Xiamen University
Xiamen , Fujian
The Affiliated Hospital of Xuzhou Medical University
Xuzhou , Jiangsu
Henan Cancer Hospital
Zhengzhou , Henan
The First Affiliated Hospital of Zhengzhou University
Zhengzhou , Henan
The Fifth Affiliated Hospital Sun Yat Sen University
Zhuhai , Guangdong
The Second Affiliated Hospital of Zunyi Medical University
Zuiyi , Guizhou
Франция (5)
Hopital Beaujon
Clichy
Hopital Prive Jean Mermoz
Lyon
Icm Val Daurelle
Montpellier
Centre Hospitalier Universitaire Nantes Hotel Dieu
Nantes
Hopital Larchet 2 Chu Nice
Nice
Италия (3)
Policlinico Sorsola Malpighi, Aou Di Bologna
Bologna
Aou Pisana, Stabilimento Di Santa Chiara
Pisa
Azienda Ospedaliera S Maria Di Terni
Terni
Япония (7)
Akita University Hospital
Akitashi , Akita
Chiba Cancer Center
Chiba , Chiba
National Cancer Center Hospital
ChuoKu , Tokyo
Nho Kyushu Cancer Center
Fukuoka , Fukuoka
Izumi City General Hospital
Izumishi , Osaka
Hokkaido University Hospital
Sapporo , Hokkaido
The University of Osaka Hospital
Suitashi , Osaka
Malaysia (2)
University Malaya Medical Centre
Kuala Lumpur
Sarawak General Hospital
Kuching
New Zealand (1)
Auckland City Hospital
Auckland
Полша (2)
Szpitale Pomorskie Spolka Z Ograniczona Odpowiedzialnoscia
Gdynia
Narodowy Instytut Onkologii Im Marii Sklodowskiej Curie W Warszawie
Warsaw
Южна Корея (14)
Cha Bundang Medical Center, Cha University
BundangGu SeongnamSi , Gyeonggi-do
Smg Snu Boramae Medical Center
DongjakGu , Seoul Teugbyeolsi
Samsung Medical Center
GangnamGu , Seoul Teugbyeolsi
Korea University Guro Hospital
GuroGu , Seoul Teugbyeolsi
Chonnam National University Hwasun Hospital
HwasunGun , Jeollanam-do
National Cancer Center (Korea)
IlsandongGu GoyangSi , Gyeonggi-do
Gachon University Gil Medical Center
NamdongGu , Incheon Gwang'yeogsi
The Catholic University of Korea, St Vincents Hospital
PaldalGu SuwonSi , Gyeonggi-do
The Catholic University of Korea, Seoul St Marys Hospital
SeochoGu , Seoul Teugbyeolsi
Severance Hospital Yonsei University Health System
SeodaemunGu , Seoul Teugbyeolsi
Seoul National University Bundang Hospital
Seongnam-si , Gyeonggi-do
Seoul National University Hospital
Seoul , Seoul Teugbyeolsi
Asan Medical Center
SongpaGu , Seoul Teugbyeolsi
Ajou University Hospital
Suwon
Taiwan (7)
Chiayi Chang Gung Memorial Hospital
Chiayi City
Linkou Chang Gung Memorial Hospital
Guishan Dist
Kaohsiung Chang Gung Memorial Hospital
Niaosong Dist
National Cheng Kung University Hospital
North Dist
China Medical University Hospital
Taichung
Taichung Veterans General Hospital
Taichung
Chi Mei Medical Center
Yongkang Dist
Тайланд (1)
King Chulalongkorn Memorial Hospital (Chulalongkorn University)
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