Ryme Medical TLD Pilot Study

Targeted lung denervation (TLD) with the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD) - Ryme Medical TLD Pilot Study

The study is a prospective, multi-center, non-randomized study to evaluate the safety and performance of the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD)

Key Inclusion Criteria: * Symptomatic chronic obstructive pulmonary disease * ≥40 years of age * Smoking history of at least 10 pack years * Candidate for bronchoscopy in the opinion of the Investigator Key Exclusion Criteria: * Recent COPD exacerbation or respiratory infection * Prior lung intervention with device in place * Pulmonary nodule or malignancy requiring treatment * Current chemotherapy or radiation therapy and/or has received treatment within 6 months * Current smoker, using e-cigarettes or vaping, or taking any inhaled substances not prescribed by a physician * Clinically significant serious or unstable medical conditions (e.g., heart disease requiring treatment, uncontrolled diabetes) * Pregnant, nursing, or intent to become pregnant during study duration