A Study to Evaluate the Treatment Response and Safety of Two Dose Regimens of Subcutaneous Amlitelimab Compared With Treatment Withdrawal in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis
Фаза 3 – широко изпитване преди одобрение
Заболявания:
Dermatitis Atopic
Спонсор: Sanofi
Налично на:
БГ
Обобщение
This is a multinational, multicenter, randomized, double-blind, placebo-controlled, parallel, Phase 3 study for treatment of participants aged 12 years and older diagnosed with moderate-to-severe atopic dermatitis (AD).
The primary objective of ESTUARY is to assess the maintenance of treatment response on continued Q12W dosing compared to treatment withdrawal.
Study details include:
The study duration will be up to 68 weeks including a 52-week randomized double-blind period, and a 16-week safety follow-up for participants not entering the LTS17367 (RIVER-AD).
The study duration will be up to 52 weeks for participants entering the LTS17367 \[RIVER-AD\] study at the Week 52 visit of EFC17600 (ESTUARY).
Кой може да участва
Inclusion Criteria:
* Participants must be at least 12 years of age inclusive, at the time the informed consent is signed.
* Must have participated, received study treatment without permanent investigational medicinal product (IMP) discontinuation, and adequately completed the assessments required for the treatment period in one of the three 24-week parent studies EFC17559 (COAST-1), EFC17560 (COAST-2) or EFC17561 (SHORE) for moderate-to-severe AD.
* Able and willing to comply with requested study visit and procedures.
* Body weight must be ≥ 25 kg.
Exclusion Criteria:
Participants are excluded from the study if any of the following criteria apply:
* Developed a medical condition that would preclude participation as described in Exclusion Criteria or Permanent Discontinuation of EFC17559 (COAST-1)/EFC17560 (COAST-2)/EFC17561 (SHORE) clinical trial protocols.
* Having received any prohibited medication or procedure for AD that resulted in IMP discontinuation in the parent study EFC17559 (COAST-1), EFC17560 (COAST-2) or EFC17561 (SHORE).
* Participants who, during their participation in the parent study EFC17559 (COAST-1) /EFC17560 (COAST-2)/EFC17561 (SHORE), developed an adverse event (AE) or a serious adverse event (SAE) deemed related to amlitelimab, which in the opinion of the Investigator could indicate that continued treatment with amlitelimab may present an unreasonable risk for the participant.
* Participants who have had IMP permanently discontinued for any reason before or at the time of the planned first dose in the EFC17600 (ESTUARY) study.
* Conditions in the parent study EFC17559 (COAST-1)/EFC17560 (COAST-2)/EFC17561 (SHORE) that led to Investigator - or Sponsor-initiated withdrawal of participant from the study (eg, non-compliance, inability to complete study assessments, etc.).
* Participant not suitable for participation, whatever the reason, as judged by the Investigator, including medical or clinical conditions, or participants potentially at risk of noncompliance to study procedures.
The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Интервенции
Amlitelimab
DRUG
Placebo
DRUG
Места на провеждане
326
Argentina (22)
Investigational Site Number : 0320021
Berazategui , Buenos Aires
Investigational Site Number : 0320022
Buenos Aires
Investigational Site Number : 0320023
Buenos Aires
Investigational Site Number : 0320011
Buenos Aires
Investigational Site Number : 0320016
Buenos Aires
Investigational Site Number : 0320008
Buenos Aires
Investigational Site Number : 0320001
Buenos Aires
Investigational Site Number : 0320018
Buenos Aires
Investigational Site Number : 0320010
Buenos Aires
Investigational Site Number : 0320002
Buenos Aires
Investigational Site Number : 0320004
Buenos Aires
Investigational Site Number : 0320009
Buenos Aires
Investigational Site Number : 0320019
Buenos Aires
Investigational Site Number : 0320005
Buenos Aires
Investigational Site Number : 0320012
Corrientes
Investigational Site Number : 0320013
Mendoza
Investigational Site Number : 0320017
Pilar , Buenos Aires
Investigational Site Number : 0320006
Rosario , Santa Fe Province
Investigational Site Number : 0320007
Rosario , Santa Fe Province
Investigational Site Number : 0320015
Rosario , Santa Fe Province
Investigational Site Number : 0320024
San Miguel de Tucumán , Tucumán Province
Investigational Site Number : 0320020
San Miguel de Tucumán , Tucumán Province
Австралия (5)
Investigational Site Number : 0360008
Melbourne , Victoria
Investigational Site Number : 0360006
Melbourne , Victoria
Investigational Site Number : 0361006
Traralgon , Victoria
Investigational Site Number : 0360010
Westmead , New South Wales
Investigational Site Number : 0360007
Woolloongabba , Queensland
Бразилия (14)
Hospital São Domingos- Site Number : 0760028
Bequimão , Maranhão
Hospital de Clinicas da Universidade Federal do Parana- Site Number : 0760022
Curitiba , Paraná
PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR- Site Number : 0760023
Curitiba , Paraná
Irmandade da Santa Casa de Misericórdia de Porto Alegre- Site Number : 0760005
Porto Alegre , Rio Grande do Sul
Hospital São Lucas da PUCRS - Porto Alegre - Avenida Ipiranga- Site Number : 0760024
Porto Alegre , Rio Grande do Sul
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto- Site Number : 0760015
Ribeirão Preto , São Paulo
CCBR / IBPClin - Instituto Brasil de Pesquisa Clínica- Site Number : 0760018
Rio de Janeiro
Centro de Pesquisas da Clínica IBIS- Site Number : 0760002
Salvador , Estado de Bahia
Faculdade de Medicina do ABC- Site Number : 0760001
Santo André , São Paulo
Hospital Alemao Oswaldo Cruz - São Paulo- Site Number : 0760010
São Paulo
Centro de Desenvolvimento em Estudos ClÌnicos Brasil- Site Number : 0760014
São Paulo
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo- Site Number : 0760012
São Paulo
Clinica de Alergia Martti Antila- Site Number : 0760006
Sorocaba , São Paulo
Centro de Diagnostico e Pesquisa da Osteoporose do Espirito Santo- Site Number : 0760017
Vitória , Espírito Santo
България (3)
Investigational Site Number : 1002007
Dupnitsa
Investigational Site Number : 1002004
Pleven
Investigational Site Number : 1002005
Sofia
Канада (20)
Investigational Site Number : 1240033
Ajax , Ontario
Investigational Site Number : 1240039
Calgary , Alberta
Investigational Site Number : 1240031
Edmonton , Alberta
Investigational Site Number : 1240046
Kelowna , British Columbia
Investigational Site Number : 1240029
London , Ontario
Investigational Site Number : 1241106
Markham , Ontario
Investigational Site Number : 1240008
Mississauga , Ontario
Investigational Site Number : 1241108
Niagara Falls , Ontario
Investigational Site Number : 1240034
Ottawa , Ontario
Investigational Site Number : 1240006
Québec , Quebec
Investigational Site Number : 1240045
Red Deer , Alberta
Investigational Site Number : 1240028
Regina , Saskatchewan
Investigational Site Number : 1240038
Richmond Hill , Ontario
Investigational Site Number : 1240036
Saskatoon , Saskatchewan
Investigational Site Number : 1240040
Surrey , British Columbia
Investigational Site Number : 1240030
Surrey , British Columbia
Investigational Site Number : 1240012
Toronto , Ontario
Investigational Site Number : 1240035
Toronto , Ontario
Investigational Site Number : 1241107
Waterloo , Ontario
Investigational Site Number : 1240041
Winnipeg , Manitoba
Chile (14)
Investigational Site Number : 1520009
Osorno , Reg Metropolitana de Santiago
Investigational Site Number : 1520015
Quillota , Valparaiso
Investigational Site Number : 1520013
Santiago , Reg Metropolitana de Santiago
Investigational Site Number : 1520008
Santiago , Reg Metropolitana de Santiago
Investigational Site Number : 1520002
Santiago , Reg Metropolitana de Santiago
Investigational Site Number : 1520003
Santiago , Reg Metropolitana de Santiago
Investigational Site Number : 1520014
Santiago , Reg Metropolitana de Santiago
Investigational Site Number : 1520010
Santiago , Reg Metropolitana de Santiago
Investigational Site Number : 1520011
Santiago , Reg Metropolitana de Santiago
Investigational Site Number : 1520005
Santiago , Reg Metropolitana de Santiago
Investigational Site Number : 1520001
Santiago , Reg Metropolitana de Santiago
Investigational Site Number : 1520012
Talcahuano , Biobio
Investigational Site Number : 1520004
Valdivia , Los Ríos Region
Investigational Site Number : 1520006
Viña del Mar , Valparaiso
Китай (29)
Investigational Site Number : 1560042
Beijing
Investigational Site Number : 1560004
Beijing
Investigational Site Number : 1560030
Beijing
Investigational Site Number : 1560050
Changsha
Investigational Site Number : 1560022
Chengdu
Investigational Site Number : 1560060
Chengdu
Investigational Site Number : 1560068
Chengdu
Investigational Site Number : 1560057
Chongqing
Investigational Site Number : 1560065
Chongqing
Investigational Site Number : 1560043
Fuzhou
Investigational Site Number : 1560021
Guangzhou
Investigational Site Number : 1560025
Guangzhou
Investigational Site Number : 1560058
Guangzhou
Investigational Site Number : 1560044
Hangzhou
Investigational Site Number : 1560002
Hangzhou
Investigational Site Number : 1560006
Hangzhou
Investigational Site Number : 1560029
Hangzhou
Investigational Site Number : 1560007
Jinan
Investigational Site Number : 1560051
Nanchang
Investigational Site Number : 1560024
Ningbo
Investigational Site Number : 1560001
Shanghai
Investigational Site Number : 1560005
Shanghai
Investigational Site Number : 1560041
Shenyang
Investigational Site Number : 1560026
Shenyang
Investigational Site Number : 1560064
Shenzhen
Investigational Site Number : 1560023
Wenzhou
Investigational Site Number : 1560049
Wuhan
Investigational Site Number : 1560003
Wuxi
Investigational Site Number : 1560028
Zhenjiang
Чехия (8)
Investigational Site Number : 2032106
Kutná Hora
Investigational Site Number : 2032105
Nový Jičín
Investigational Site Number : 2030010
Olomouc
Investigational Site Number : 2032104
Ostrava
Investigational Site Number : 2030009
Pilsen
Investigational Site Number : 2030008
Prague
Investigational Site Number : 2030011
Prague
Investigational Site Number : 2030006
Prague
Дания (3)
Investigational Site Number : 2080002
Aalborg
Investigational Site Number : 2080001
Aarhus
Investigational Site Number : 2080003
Herlev
Франция (8)
Investigational Site Number : 2500008
Antony
Investigational Site Number : 2500013
Nice
Investigational Site Number : 2500003
Paris
Investigational Site Number : 2500006
Pierre-Bénite
Investigational Site Number : 2500007
Reims
Investigational Site Number : 2500010
Romans-sur-Isère
Investigational Site Number : 2500012
Rouen
Investigational Site Number : 2500002
Toulouse
Германия (8)
Investigational Site Number : 2760020
Augsburg
Investigational Site Number : 2760009
Bad Bentheim
Investigational Site Number : 2760017
Hamburg
Investigational Site Number : 2760021
Hamburg
Investigational Site Number : 2762208
Kiel
Investigational Site Number : 2760016
Mainz
Investigational Site Number : 2762201
Münster
Investigational Site Number : 2760019
Witten
Гърция (2)
Investigational Site Number : 3000001
Athens
Investigational Site Number : 3000002
Thessaloniki
Индия (7)
Investigational Site Number : 3560001
Ahmedabad
Investigational Site Number : 3560005
Belagavi
Investigational Site Number : 3560004
Chandigarh
Investigational Site Number : 3560006
Faridabad
Investigational Site Number : 3560007
Kolkata
Investigational Site Number : 3560002
Nagpur
Investigational Site Number : 3560003
Pune
Израел (6)
Investigational Site Number : 3760004
Afula
Investigational Site Number : 3760005
Beersheba
Investigational Site Number : 3760001
Haifa
Investigational Site Number : 3760003
Jerusalem
Investigational Site Number : 3760006
Petah Tikva
Investigational Site Number : 3760002
Petah Tikva
Италия (8)
Investigational Site Number : 3800012
Bologna
Investigational Site Number : 3800009
Catania
Investigational Site Number : 3800011
L’Aquila
Investigational Site Number : 3800003
Milan , Milano
Investigational Site Number : 3800008
Pisa
Investigational Site Number : 3800013
Rome , Roma
Investigational Site Number : 3800018
Rozzano , Milano
Investigational Site Number : 3800022
Vicenza
Япония (18)
Investigational Site Number : 3920009
Chitose , Hokkaido
Investigational Site Number : 3920004
Chūō , Tokyo
Investigational Site Number : 3923109
Habikino , Osaka
Investigational Site Number : 3920002
Iruma , Saitama
Investigational Site Number : 3923108
Kagoshima
Investigational Site Number : 3920006
Kobe , Hyōgo
Investigational Site Number : 3923102
Kyoto
Investigational Site Number : 3920003
Kyoto
Investigational Site Number : 3923106
Mibu , Tochigi
Investigational Site Number : 3923107
Minato , Tokyo
Investigational Site Number : 3920010
Miyagi-gun , Miyagi
Investigational Site Number : 3923114
Obihiro , Hokkaido
Investigational Site Number : 3920005
Sagamihara , Kanagawa
Investigational Site Number : 3923110
Sakai , Osaka
Investigational Site Number : 3920008
Sapporo , Hokkaido
Investigational Site Number : 3920011
Sendai , Miyagi
Investigational Site Number : 3920001
Tachikawa , Tokyo
Investigational Site Number : 3923113
Yokohama , Kanagawa
Mexico (5)
Investigational Site Number : 4840012
Aguascalientes
Investigational Site Number : 4840009
Durango
Investigational Site Number : 4840011
Monterrey , Nuevo León
Investigational Site Number : 4840005
Monterrey , Nuevo León
Investigational Site Number : 4840003
Veracruz
Полша (8)
Investigational Site Number : 6160006
Gdansk , Pomeranian Voivodeship
Investigational Site Number : 6160003
Katowice , Silesian Voivodeship
Investigational Site Number : 6162406
Krakow , Lesser Poland Voivodeship
Investigational Site Number : 6160002
Lodz , Lódzkie
Investigational Site Number : 6160004
Lublin , Lublin Voivodeship
Investigational Site Number : 6160010
Tarnów , Lesser Poland Voivodeship
Investigational Site Number : 6160009
Warsaw , Masovian Voivodeship
Investigational Site Number : 6160007
Warsaw , Masovian Voivodeship
Португалия (4)
Investigational Site Number : 6200005
Lisbon
Investigational Site Number : 6200004
Lisbon
Investigational Site Number : 6200001
Lisbon
Investigational Site Number : 6200003
Porto
South Africa (7)
Investigational Site Number : 7100015
Benoni
Investigational Site Number : 7100010
Cape Town
Investigational Site Number : 7100009
Cape Town
Investigational Site Number : 7100012
Durban
Investigational Site Number : 7100001
Durban
Investigational Site Number : 7100007
Johannesburg
Investigational Site Number : 7100003
Pretoria
Южна Корея (13)
Investigational Site Number : 4100002
Ansan-si , Gyeonggi-do
Investigational Site Number : 4100015
Bupyeong-gu , Incheon-gwangyeoksi
Investigational Site Number : 4100008
Daegu , Daegu
Investigational Site Number : 4100012
Gwangju , Gwangju
Investigational Site Number : 4100014
Seongnam-si , Gyeonggi-do
Investigational Site Number : 4100010
Seoul , Seoul-teukbyeolsi
Investigational Site Number : 4100013
Seoul , Seoul-teukbyeolsi
Investigational Site Number : 4100007
Seoul , Seoul-teukbyeolsi
Investigational Site Number : 4100006
Seoul , Seoul-teukbyeolsi
Investigational Site Number : 4100011
Seoul , Seoul-teukbyeolsi
Investigational Site Number : 4100017
Seoul , Seoul-teukbyeolsi
Investigational Site Number : 4100009
Suwon , Gyeonggi-do
Investigational Site Number : 4100003
Yangsan , Gyeongsangnam-do
Испания (12)
Investigational Site Number : 7242505
Alicante
Investigational Site Number : 7240008
Bilbao , Basque Country
Investigational Site Number : 7240023
Burjassot - Valencia , Valenciana, Comunidad
Investigational Site Number : 7240010
Esplugues de Llobregat , Barcelona [Barcelona]
Investigational Site Number : 7240018
Granada
Investigational Site Number : 7240019
Granada
Investigational Site Number : 7240012
Las Palmas de Gran Canaria , Las Palmas
Investigational Site Number : 7240029
Madrid
Investigational Site Number : 7242503
Madrid
Investigational Site Number : 7240015
Pamplona , Navarre
Investigational Site Number : 7240020
Seville , Sevilla
Investigational Site Number : 7240014
Vigo , Pontevedra [Pontevedra]
Швеция (2)
Investigational Site Number : 7520006
Älvsjö
Investigational Site Number : 7520001
Örebro
Taiwan (4)
Investigational Site Number : 1583201
Kaohsiung City
Investigational Site Number : 1583202
Taichung
Investigational Site Number : 1580001
Taipei
Investigational Site Number : 1580003
Taipei
Турция (9)
Investigational Site Number : 7920001
Antalya
Investigational Site Number : 7920008
Gaziantep
Investigational Site Number : 7920005
Istanbul
Investigational Site Number : 7920006
Istanbul
Investigational Site Number : 7920002
Istanbul
Investigational Site Number : 7920009
Istanbul
Investigational Site Number : 7920004
Kayseri
Investigational Site Number : 7920011
Mersin
Investigational Site Number : 7920007
Samsun
Великобритания (5)
Investigational Site Number : 8260006
Glasgow
Investigational Site Number : 8260004
Leicester , Leicestershire
Investigational Site Number : 8262601
London , London, City of
Investigational Site Number : 8262602
London , London, City of
Investigational Site Number : 8260003
Portsmouth , Hampshire
САЩ (82)
The University of New Mexico- Site Number : 8401263
Albuquerque , New Mexico
Arlington Research Center- Site Number : 8401248
Arlington , Texas
Care Access - Arlington- Site Number : 8401134
Arlington , Virginia
Bexley Dermatology Research- Site Number : 8401051
Bexley , Ohio
Cahaba Dermatology & Skin Health Center- Site Number : 8401066
Birmingham , Alabama
Equity Medical - Bowling Green- Site Number : 8401296
Bowling Green , Kentucky
MetroBoston Clinical Partners - Brighton- Site Number : 8401128
Brighton , Massachusetts
Best Skin Research - Camp Hill- Site Number : 8401031
Camp Hill , Pennsylvania
Columbia Dermatology & Aesthetics- Site Number : 8401166
Columbia , South Carolina
AllerVie Clinical Research - Columbus- Site Number : 8401104
Columbus , Georgia
Pediatric Skin Research- Site Number : 8401198
Coral Gables , Florida
MedPharmics - Covington- Site Number : 8401137
Covington , Louisiana
Dermatology Treatment and Research Center- Site Number : 8401164
Dallas , Texas
Derm Texas- Site Number : 8401217
Dallas , Texas
Cleaver Medical Group- Site Number : 8401138
Dawsonville , Georgia
Henry Ford Hospital- Site Number : 8401044
Detroit , Michigan
St. Jude Clinical Research- Site Number : 8401287
Doral , Florida
Encino Research Center- Site Number : 8401042
Encino , California
AXIS Clinicals - Fargo- Site Number : 8401196
Fargo , North Dakota
UConn Health - Farmington- Site Number : 8401115
Farmington , Connecticut
First Georgia Physician Group- Site Number : 8401190
Fayetteville , Georgia
Beth Israel Deaconess Medical Center - Fort Myers- Site Number : 8401286
Fort Myers , Florida
Johnson Dermatology- Site Number : 8401076
Fort Smith , Arkansas
First OC Dermatology- Site Number : 8401025
Fountain Valley , California
Center for Dermatology Clinical Research- Site Number : 8401018
Fremont , California
Tribe Clinical Research - Greenville - Verdae Boulevard- Site Number : 8401225
Greenville , South Carolina
BRCR Global Gretna- Site Number : 8401243
Gretna , Louisiana
Direct Helpers Research Center- Site Number : 8401056
Hialeah , Florida
Care Access - Hoboken- Site Number : 8401132
Hoboken , New Jersey
Encore Medical Research - Hollywood- Site Number : 8401030
Hollywood , Florida
Prolato Clinical Research Center- Site Number : 8401209
Houston , Texas
Marvel Clinical Research- Site Number : 8401102
Huntington Beach , California
Dawes Fretzin Clinical Research- Site Number : 8401015
Indianapolis , Indiana
Sunwise Clinical Research- Site Number : 8401022
Lafayette , California
Velocity Clinical Research - Lafayette- Site Number : 8401152
Lafayette , Louisiana
Jubilee Clinical Research- Site Number : 8401054
Las Vegas , Nevada
Tanner Clinic - Layton Antelope A- Site Number : 8401151
Layton , Utah
Torrance Clinical Research - Narbonne Avenue- Site Number : 8401027
Lomita , California
Dermatology Research Associates - Los Angeles- Site Number : 8401092
Los Angeles , California
LA Universal Research Center- Site Number : 8401064
Los Angeles , California
Skin Sciences- Site Number : 8401039
Louisville , Kentucky
Skin Care Physicians of Georgia - Macon- Site Number : 8401034
Macon , Georgia
Apex Clinical Research Center- Site Number : 8401237
Mayfield Heights , Ohio
SMS Clinical Research- Site Number : 8401182
Mesquite , Texas
Clever Medical Research- Site Number : 8401160
Miami , Florida
Acevedo Clinical Research Associates- Site Number : 8401088
Miami , Florida
Florida International Research Center- Site Number : 8401091
Miami , Florida
Miami Dermatology and Laser Research - Miami - Southwest 87th Avenue- Site Number : 8401086
Miami , Florida
Anchor Medical Research- Site Number : 8401300
Miami , Florida
Savin Medical Group - Miami Lakes- Site Number : 8401085
Miami Lakes , Florida
Synapse Clinical Research - Missouri City- Site Number : 8401148
Missouri City , Texas
Equity Medical- Site Number : 8401239
New York , New York
Icahn School of Medicine at Mount Sinai- Site Number : 8401129
New York , New York
Sadick Research Group - New York - Park Avenue- Site Number : 8401050
New York , New York
OptiSkin- Site Number : 8401163
New York , New York
Virginia Dermatology & Skin Cancer Center- Site Number : 8401047
Norfolk , Virginia
Northridge Clinical Trials - Northridge- Site Number : 8401080
Northridge , California
Skin Specialists- Site Number : 8401068
Omaha , Nebraska
Cura Clinical Research - Oxnard- Site Number : 8401142
Oxnard , California
Paddington Testing Company- Site Number : 8401041
Philadelphia , Pennsylvania
Clinical Research of Philadelphia- Site Number : 8401193
Philadelphia , Pennsylvania
Dermatology Associates of Plymouth Meeting- Site Number : 8401147
Plymouth Meeting , Pennsylvania
Nuline Clinical Trial Center- Site Number : 8401161
Pompano Beach , Florida
Oregon Medical Research Center- Site Number : 8401017
Portland , Oregon
Health Concepts- Site Number : 8401059
Rapid City , South Dakota
SKY Integrative Medical Center/SKYCRNG - Ridgeland- Site Number : 8401058
Ridgeland , Mississippi
Texas Dermatology and Laser Specialists - San Antonio - Oakwell Court- Site Number : 8401131
San Antonio , Texas
Southern California Dermatology- Site Number : 8401043
Santa Ana , California
Clinical Science Institute- Site Number : 8401028
Santa Monica , California
Center for Dermatology and Plastic Surgery- Site Number : 8401119
Scottsdale , Arizona
Scottsdale Clinical Trials- Site Number : 8401149
Scottsdale , Arizona
NorthShore University Health System - Endeavor Health Medical Group - Skokie - Woods Drive- Site Number : 8401038
Skokie , Illinois
Stryde Research - Epiphany Dermatology- Site Number : 8401185
Southlake , Texas
Global Clinical Professionals (GCP)- Site Number : 8401045
St. Petersburg , Florida
Complete Dermatology - Sugar Land- Site Number : 8401061
Sugar Land , Texas
Clinical Research Trials of Florida- Site Number : 8401023
Tampa , Florida
Javara Research - Thomasville- Site Number : 8401189
Thomasville , Georgia
Revival Research Institute - Troy- Site Number : 8401012
Troy , Michigan
Oakland Medical Center- Site Number : 8401116
Troy , Michigan
Eclipse Clinical Research- Site Number : 8401158
Tucson , Arizona
Rophe Adult & Pediatric Medicine- Site Number : 8401289
Union City , Georgia
Allergy & Immunology Associates of Ann Arbor- Site Number : 8401078
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