OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
Фаза 3 – широко изпитване преди одобрение
Заболявания:
Cardiovascular Disease
Спонсор: Amgen
Налично на:
БГ
Обобщение
The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).
Кой може да участва
Inclusion Criteria:
* Age ≥50 years
* Lp(a)≥ 200 nmol/L during screening
* Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis
Exclusion Criteria:
* Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia)
* Prior or planned arterial revascularization
* History of major bleeding disorder
Интервенции
Olpasiran
DRUG
Placebo
DRUG
Места на провеждане
242
Австралия (22)
Advara HeartCare Wesley
Auchenflower , Queensland
Flinders Medical Centre
Bedford Park , South Australia
Royal Prince Alfred Hospital
Camperdown , New South Wales
Novatrials
Charlestown , New South Wales
Victorian Heart Hospital
Clayton , Victoria
Concord Repatriation General Hospital
Concord , New South Wales
Canberra Hospital
Garran , Australian Capital Territory
Clinitrials - Mandurah
Greenfields , Western Australia
Advara HeartCare Joondalup
Joondalup , Western Australia
Advara HeartCare Leabrook
Leabrook , South Australia
The Alfred Hospital
Melbourne , Victoria
Momentum Clinical Research - Sunshine
Melbourne , Victoria
Aim Research
Merewether , New South Wales
Core Research Group Pty Ltd
Milton , Queensland
Hollywood Private Hospital
Nedlands , Western Australia
Linear Clinical Research Limited
Nedlands , Western Australia
Fusion Clinical Research
Norwood , South Australia
Orange Health Service
Orange , New South Wales
Clinitrials - Mount Medical Centre
Perth , Western Australia
University of The Sunshine Coast Clinical Trials, Sippy Downs
Sippy Downs , Queensland
Wollongong Hospital
Wollongong , New South Wales
Dr Heart Pty Ltd
Woolloongabba , Queensland
Канада (20)
Centricity Research Brampton
Brampton , Ontario
Centricity Research Calgary
Calgary , Alberta
Ecogene-21
Chicoutimi , Quebec
Edmonton Cardiology Consultants
Edmonton , Alberta
Premier Clinical Trial Network
Hamilton , Ontario
Elevate Clinical Research KMH Missisauga
Mississauga , Ontario
Montreal Heart Institute
Montreal , Quebec
Institut de recherches cliniques de Montreal
Montreal , Quebec
Centre de Recherche du Centre Hospitalier de l Universite de Montreal
Montreal , Quebec
Research Institute of McGill University Health Center - Glen Site
Montreal , Quebec
Fraser Clinical Trials
New Westminster , British Columbia
Partners in Advanced Cardiac Evaluation
Newmarket , Ontario
North York Diagnostic and Cardiac Centre
North York , Ontario
Oakville Cardiovascular Research
Oakville , Ontario
Heart Health Institute Research Incorporated
Scarborough Village , Ontario
CIUSSS de l Estrie CHUS Hopital Fleurimont
Sherbrooke , Quebec
SMH Cardiology Clinical Trials Incorporated
Surrey , British Columbia
ARC Biosystems Incorporated
Vancouver , British Columbia
Victoria Heart Institute Foundation
Victoria , British Columbia
Discovery Clinical Services Ltd
Victoria , British Columbia
САЩ (200)
Albany Medical College
Albany , New York
Advanced Cardiovascular LLC
Alexander City , Alabama
PharmaTex Research, LLC
Amarillo , Texas
Endeavor Health-Northwest Community Healthcare
Arlington Heights , Illinois
Emory University Hospital
Atlanta , Georgia
Texas Diabetes and Endocrinology
Austin , Texas
Ima Clinical Research
Austin , Texas
Ascension Saint Agnes Heart Care
Baltimore , Maryland
Johns Hopkins Hospital
Baltimore , Maryland
Metropolitan Cardiovascular Consultants LLC
Beltsville , Maryland
Suburban Hospital
Bethesda , Maryland
National Heart Institute
Beverly Hills , California
University of Alabama Birmingham Saint Vincents Birmingham
Birmingham , Alabama
Birmingham Clinical Research
Birmingham , Alabama
Excel Medical Clinical Trials
Boca Raton , Florida
Brigham and Womens Hospital
Boston , Massachusetts
Flourish Research
Bowie , Maryland
Graves Gilbert Clinic
Bowling Green , Kentucky
Sisters of Saint Mary Health Heart and Vascular Care
Bridgeton , Missouri
East Coast Institute for Research
Canton , Georgia
Aultman Cardiology Clinical Trials
Canton , Ohio
Pioneer Medical Associates
Carrollton , Texas
Christie Clinic
Champaign , Illinois
Pharmacorp Clinical Trials Inc
Charleston , South Carolina
Medical University of South Carolina
Charleston , South Carolina
Erlanger Health, Inc.
Chattanooga , Tennessee
The Christ Hospital
Cincinnati , Ohio
Velocity Clinical Research - Cincinnati
Cincinnati , Ohio
Clearwater Cardiovascular Consultants
Clearwater , Florida
UCHealth Memorial Central
Colorado Springs , Colorado
Johns Hopkins University
Columbia , Maryland
Centennial Medical Group
Columbia , Maryland
Heart Clinic of Hammond
Covington , Louisiana
Northeast Georgia Medical Center Wisteria Building
Cumming , Georgia
Baylor Scott and White Heart and Vascular Hospital-Dallas
Dallas , Texas
Zenos Clinical Research
Dallas , Texas
The Heartbeat Clinic
Dallas , Texas
Cedar Health Research, LLC
Dallas , Texas
Alliance For Multispecialty Research - Daphne
Daphne , Alabama
Henry Ford Health System
Detroit , Michigan
Saint Marys Medical Center
Duluth , Minnesota
Duke University Health System
Durham , North Carolina
Miriam Hospital
East Greenwich , Rhode Island
Cedar Health Research, LLC
Euless , Texas
MediSphere Medical Research Center LLC
Evansville , Indiana
Western Washington Medical Group
Everett , Washington
Inova Cardiology - Fairfax
Fairfax , Virginia
Eastern Shore Research Institute
Fairhope , Alabama
Virginia Heart
Falls Church , Virginia
Advanced Heart and Vascular Institute of Hunterdon
Flemington , New Jersey
Proactive Clinical Research
Fort Lauderdale , Florida
Parkview Research Center
Fort Wayne , Indiana
Prisma Health Carolina Cardiology - Greenville
Gantt , South Carolina
Healthy Heart Cardiology
Grand Rapids , Michigan
Moses H Cone Memorial Hospital
Greensboro , North Carolina
Medication Management LLC
Greensboro , North Carolina
Triad Clinical Trials, LLC
Greensboro , North Carolina
Gandelman Cardiology, PC
Greenwich , Connecticut
ClinTrial Hamden
Hamden , Connecticut
Clinical Reseach Philadelphia Pennington
Hamilton , New Jersey
Indago Research and Health Center
Hialeah , Florida
Elite Cardiac Research Center LLC
Hialeah , Florida
East Texas Cardiology PA
Houston , Texas
Baylor College of Medicine
Houston , Texas
Cardiovascular Specialists of Willowbrook
Houston , Texas
Vital Heart and Vein
Humble , Texas
Heart Center Research LLC
Huntsville , Alabama
Hutchinson Clinic PA
Hutchinson , Kansas
Medstar Franklin Square Medical Center
Hyattsville , Maryland
Franciscan Health Indianapolis
Indianapolis , Indiana
Ascension Saint Vincent Heart Center
Indianapolis , Indiana
310 Clinical Research
Inglewood , California
Basil Clinical
Inwood , New York
Med Clinical Research Partners - Irvington
Irvington , New Jersey
Jackson Heart Clinic
Jackson , Mississippi
Apex Research Foundation, LLC
Jackson , Tennessee
Rasai Research
Jackson Heights , New York
Jacksonville Center for Clinical Research
Jacksonville , Florida
Nsc Research
Johns Creek , Georgia
University of Kansas Medical Center
Kansas City , Kansas
Kansas City Veterans Affairs Medical Center
Kansas City , Missouri
Tcr Institute Llc
Kingwood , Texas
ClinCept, LLC
Kinston , North Carolina
Alliance for Multispecialty Research Knoxville
Knoxville , Tennessee
University of California San Diego
La Jolla , California
East Coast Institute for Research, LLC
Lake City , Florida
Capitol Cardiology Associates
Lanham , Maryland
Excel Clinical Research
Las Vegas , Nevada
American Institute of Medical Research
Las Vegas , Nevada
Georgia Clinical Research
Lawrenceville , Georgia
Alpine Research Organization
Layton , Utah
Virginia Heart - Loudoun
Leesburg , Virginia
Epic Clinical Research
Lewisville , Texas
The Research Group of Lexington LLC
Lexington , Kentucky
Nexgen Research
Lima , Ohio
Bryan Heart
Lincoln , Nebraska
New Jersey Medcare / New Jersey Heart
Linden , New Jersey
Walker Family Care
Little River , South Carolina
Lynn Institute of the Ozarks
Little Rock , Arkansas
South Denver Cardiology Associates
Littleton , Colorado
InvivoCure
Los Angeles , California
Texas Tech University Health Sciences Center
Lubbock , Texas
Carient Heart and Vascular
Manassas , Virginia
Health East Cancer Care
Maplewood , Minnesota
K and R Research
Marion , Ohio
North Dallas Research Associates
McKinney , Texas
Revival Research Institute
McKinney , Texas
Texas Institute of Cardiology
McKinney , Texas
St Lukes Idaho Cardiology Associates
Meridian , Idaho
Solaris Clinical Research
Meridian , Idaho
Southern Endocrinology Associates PA
Mesquite , Texas
Columbus Clinical Services LLC
Miami , Florida
Kendall South Medical Center
Miami , Florida
Inpatient Research Clinic, LLC
Miami Lakes , Florida
Panax Clinical Research
Miami Lakes , Florida
MyMichigan Medical Center Midland - Clinical Research Department
Midland , Michigan
Bon Secours Cardiology
Midlothian , Virginia
University of Minnesota
Minneapolis , Minnesota
Eminat, LLC
Miramar , Florida
CB Flock Research Corporation
Mobile , Alabama
Ima Clinical Research
Monroe , Louisiana
Crystal Run Healthcare
Monroe , New York
Monroe Biomedical Research
Monroe , North Carolina
Accellacare Charleston
Mt. Pleasant , South Carolina
Cardiovascular Research of Northwest Indiana LLC
Munster , Indiana
Ascension Saint Thomas
Nashville , Tennessee
Suncoast Clinical Research Inc
New Port Richey , Florida
Icahn School of Medicine at Mount Sinai
New York , New York
Mount Sinai Queens
New York , New York
Ima Clinical Research Manhattan
New York , New York
Saint Michaels Medical Center
Newark , New Jersey
Tidewater Physicians Multispecialty Group Clinical Research
Newport News , Virginia
Niagara Falls Memorial Medical Center
Niagara Falls , New York
Alliance for Multispecialty Research Norfolk
Norfolk , Virginia
Alliance for Multispecialty Research
Norman , Oklahoma
Las Vegas Clinical Trials
North Las Vegas , Nevada
Valley Clinical Trials
Northridge , California
Parkway Cardiology Associates
Oak Ridge , Tennessee
Ocala Cardiovascular Research
Ocala , Florida
Ocala Research Institute, Inc
Ocala , Florida
Circuit Clinical Orchard Park Family Practice
Orchard Park , New York
Ormond Beach Clinical Research
Ormond Beach , Florida
Midwest Heart and Vascular Specialists
Overland Park , Kansas
Advocate Lutheran General Hospital
Park Ridge , Illinois
Alliance for Multispecialty Research LLC - Park Ridge
Park Ridge , Illinois
Orion Medical
Pasadena , Texas
Baptist Health Care
Pensacola , Florida
University of Pennsylvania
Philadelphia , Pennsylvania
Phoenix Clinical
Phoenix , Arizona
Elite Clinical Studies LLC
Phoenix , Arizona
Hero Clinical Research
Phoenix , Arizona
Preferred Primary Care Physicians, Inc
Pittsburgh , Pennsylvania
Valley Institute of Research Plano
Plano , Texas
Denali Health Plant City
Plant City , Florida
Pottstown Medical Specialists Inc
Pottstown , Pennsylvania
Hudson Valley Cardiovascular Physicians PC
Poughkeepsie , New York
Monument Health Clinical Research
Rapid City , South Dakota
Renown Institute for Heart and Vascular Health
Reno , Nevada
Rainier Clinical Research Center
Renton , Washington
Reid Physician Associates
Richmond , Indiana
Mayo Clinic
Rochester , Minnesota
Advanced Cardiology Associates
Rochester Hills , Michigan
Clinical Trials Research - Sacramento
Roseville , California
Methodist Hospital
Saint Louis Park , Minnesota
Ima Clinical Research San Antonio
San Antonio , Texas
Alliance Clinical Research
San Diego , California
St Davids Heart & Vascular PLLC dba Austin Heart
San Marcos , Texas
Saratoga Clinical Research, LLC
Saratoga Springs , New York
HonorHealth Research Institute
Scottsdale , Arizona
Circuit Clinical / Optum Medical Care of New Jersey
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