Language: BG BG
← Back to results
Active (not recruiting) Phase 1/2 NCT07218770

A Study of REGN7041 for Active Noninfectious Uveitis in Adult Participants

Phase 1/2 – combined early trial
Conditions: Active Noninfectious Uveitis Affecting the Posterior Segment

Sponsor: Regeneron Pharmaceuticals

trial.available_in: БГ
Overview
This study is researching an experimental drug called REGN7041 (also referred to as "study drug"). The study is focused on patients who have active inflammation inside of the eye without any signs of infection. The aim of the study is to see how safe and tolerable the study drug is. This is the first time the study drug is being tested in humans. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood and the fluid in the eye at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)
Who can participate
Key Inclusion Criteria: 1. Diagnosis of non-infectious anterior, intermediate, posterior or panuveitis (For anterior uveitis, there must be evidence of inflammation affecting the posterior segment), as defined in the protocol 2. Active disease at baseline, as defined in the protocol 3. Part A only: Best Corrected Visual Acuity (BCVA) of ≤65 and \>10 Early Treatment Diabetic Retinopathy Study (ETDRS) letters (Snellen equivalent of worse than or equal to 20/50 and better than 20/630) at the screening visit and on day 1 4. Part B only: BCVA of \<75 and \>10 ETDRS letters (Snellen equivalent of worse than 20/32 and better than 20/630) at the screening visit and on day 1 Key Exclusion Criteria: 1. BCVA of ≤30 ETDRS letters (Snellen equivalent of 20/250 or worse) at the screening visit and/or on day 1 2. Intraocular Pressure (IOP) \<5 mm Hg at the screening visit and/or on day 1 3. IOP \>25 mm Hg on day 1. Participants are permitted to take IOP-lowering eye drops 4. Confirmed or suspected infectious uveitis, as defined in the protocol NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply
Interventions
REGN7041
DRUG
Locations 5
United States (5)
Retina Consultants of Texas - Houston
Bellaire , Texas
Retina Consultants of Texas
Katy , Texas
Tennessee Retina
Nashville , Tennessee
Illinois Retina Associates
Oak Park , Illinois
Retinal Consultants - Sacramento
Sacramento , California
Technical details
Status
Active (not recruiting)
Phase
Phase 1/2
Study type
INTERVENTIONAL
Sex
Male and female
Minimum age
18 Years
Healthy volunteers
No
Start date
17.12.2025
Completion date
28.06.2028
Registry ID
NCT07218770
Source
clinicaltrials.gov
trial.inquiry_btn

Information is automatically extracted from ClinicalTrials.gov. Consult your doctor before taking action.