The purpose of this study is to evaluate the safety and tolerability of C-1101 administered as a single dose, transforaminal epidural injection compared to sterile saline
Who can participate
Inclusion Criteria:
* Diagnosis of painful LSR (sciatica) radiating to or below the knee, with an inadequate response to conservative care
* Body mass index \< 35 kg/m2.
Exclusion Criteria:
* Presence of clinically significant disease or any other painful condition that may interfere with assessments.
* Any condition that currently requires blood or platelet transfusions.
* Diagnosed with schizophrenia, bipolar disorder, or major depressive disorder.
* Increased risk of bleeding or is taking anticoagulants or platelet aggregation inhibitors.
* History or presence of autonomic neuropathy, diabetic neuropathy, or other peripheral neuropathies.
* History of myocardial infarction within the last 6 months or congestive heart failure.
* The presence of an active malignancy or tumor.
* Have undergone a surgical procedure for back pain.
* Recent use of immunosuppressants, oral steroids, or intravenous steroids.
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