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Recruiting Not applicable NCT07525648

Comparison of the Effects of Sevoflurane and Desflurane on Optic Nerve Sheath Diameter During Laparoscopic Surgery

No applicable phase (e.g. observational)
Conditions: Intracranial Pressure Laparoscopic Surgery Optic Nerve Sheath Diameter

Sponsor: Medipol University

trial.available_in: БГ
Overview
Laparoscopic surgeries require pneumoperitoneum and Trendelenburg position, which may lead to increased intracranial pressure (ICP). Optic nerve sheath diameter (ONSD) measurement via ultrasound is a non-invasive method to evaluate ICP. This prospective study aims to compare the effects of sevoflurane and desflurane on ONSD in patients undergoing laparoscopic hysterectomy and bilateral oophorectomy in the Trendelenburg position.
Description
The primary objective of this study is to compare the ONSD values measured by ultrasound between the sevoflurane and desflurane groups. The secondary objective is to evaluate the relationship between ONSD changes, hemodynamic parameters, and postoperative neurological complications.
Who can participate
Inclusion Criteria: * Patients planned for laparoscopic hysterectomy bilateral oophorectomy surgery under general anesthesia. Exclusion Criteria: * Patients receiving beta-blocker or diuretic treatment. * Patients with severe heart failure. * Patients diagnosed with diabetes with ocular or neurological complications. * Patients who have undergone cardiac surgery, eye surgery, brain surgery, or thoracic surgery. * Patients with a history of hydrocephalus, glaucoma, intracranial mass, and stroke.
Interventions
Sevoflurane
DRUG
Desflurane
DRUG
Locations 1
Turkey (1)
Istanbul Medipol University
Istanbul
Technical details
Status
Recruiting
Phase
Not applicable
Study type
INTERVENTIONAL
Sex
Female only
Minimum age
18 Years
Maximum age
85 Years
Healthy volunteers
No
Start date
15.04.2026
Completion date
15.05.2026
Registry ID
NCT07525648
Source
clinicaltrials.gov
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