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Active (not recruiting) Not applicable NCT07539714

Development of an Active Heat Dissipation Device Based on Thermoelectric Cooling Technology: Aiming to Improve Endurance Sports Performance

No applicable phase (e.g. observational)
Conditions: Heat Stroke

Sponsor: Kaohsiung Medical University

trial.available_in: БГ
Overview
This project investigates the effectiveness of pre-exercise active cooling using a temperature-controlled cooling vest in reducing heat-related physiological strain during endurance-type aerobic exercise in non-regularly trained ("weekend") athletes under hot and humid environmental conditions. Because these individuals often lack sufficient heat-acclimation training, they are at increased risk of excessive thermal stress, cardiovascular overload, and heat-related disorders during prolonged exercise. Using a controlled laboratory design, participants will perform moderate-intensity endurance exercise in a simulated hot environment, with or without pre-cooling intervention. Peripheral circulation and thermoregulatory responses will be assessed through laser Doppler flowmetry based skin blood-flow analysis and infrared thermography, alongside heart rate and perceived exertion measures. The study aims to clarify how active pre-cooling influences vascular regulation, sympathetic activity, skin temperature distribution, and exercise tolerance, and to evaluate its potential as a practical, non-fatiguing alternative to heat-acclimation training. The findings are expected to provide evidence-based guidance for reducing heat strain and improving exercise safety and comfort in recreational endurance athletes exercising in hot climates.
Description
The primary aim of this study is to investigate the effects of pre-exercise active cooling using a temperature-controlled vest on peripheral vascular regulation mechanisms in non-regular endurance exercisers under hot environmental conditions. Specifically, this study seeks to quantify how pre-cooling modulates skin blood-flow dynamics, sympathetic nervous system activity, endothelial function, and myogenic vascular control, as assessed through frequency-domain analysis of laser Doppler flowmetry signals, before and after endurance-type aerobic exercise. By characterizing these microcirculatory responses alongside changes in skin-surface temperature measured via infrared thermography, the study aims to elucidate the physiological pathways through which active pre-cooling attenuates thermal strain and cardiovascular load during exercise in the heat.
Who can participate
Inclusion Criteria: * Age 20-50 years. * In the past 6 months, endurance exercise less than three times per week, 40-60 min each session. * No cardiovascular, metabolic (e.g., diabetes), or neurological disorders, and no diseases affecting vascular regulation. * No medication affecting vascular tone within the last 3 months. * No major musculoskeletal injuries or disorders affecting performance within the last 3 months. Exclusion Criteria: * • Diabetes, hypertension, or peripheral vascular disease. * Long-term work in hot environments. * BMI \> 30 kg/m², smoking, or heavy alcohol use. * Allergic reactions triggered by heat or cold (e.g., hives).
Interventions
TEC Vest
DEVICE
No Pre-Cooling (Without Vest)
OTHER
Water Cooled Vest
DEVICE
Locations 1
Taiwan (1)
Cooling Vest
Kaohsiung City , Sanmin
Technical details
Status
Active (not recruiting)
Phase
Not applicable
Study type
INTERVENTIONAL
Sex
Male and female
Minimum age
20 Years
Maximum age
50 Years
Healthy volunteers
No
Start date
01.02.2026
Completion date
01.05.2027
Registry ID
NCT07539714
Source
clinicaltrials.gov
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