Effects of Berberine on Cardiometabolic Outcomes

Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount. Dietary interventions to improve cardiometabolic health are highly sought after as they possess less risk than pharmacological drugs. It has been postulated that Berberine may be beneficial in improving cardiometabolic outcomes. However, to date, no research has explored this using a placebo randomized intervention.

Inclusion Criteria: * Healthy * Between 18 \& 65 years * Non-smoker * BMI \< 30 * Able to give informed consent Exclusion Criteria: * Pregnancy * Diabetes or any other metabolic/ uncontrolled hypertensive conditions * Food allergies to berberine * Habitual consumption of berberine * Not regularly taking medication or antioxidant supplements