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Not yet recruiting Phase 1 NCT07544628

A Phase 1 Study of Navlimetostat Tablet Formulations

Phase 1 – testing safety in a small group of people
Conditions: Healthy Participants

Sponsor: Bristol-Myers Squibb

trial.available_in: БГ
Overview
This study aims to compare the PK of Navlimetostat after administration of a wet-granulation tablet versus the dry-granulation tablet formulation in healthy adult female
Who can participate
Inclusion Criteria: * Participants must be healthy adult INOCBP female with no clinically significant findings on medical history, PE, VS, 12-lead ECGs, or clinical laboratory determinations, as assessed by the investigator. * Participants must have BMI of 18.0 to 35.0 kg/m2. * Participants must have adequate laboratory test results for renal and hepatic function, as assessed by the investigator, defined as eGFR ≥ 90 mL/min/1.73m2 using the CKD-EPI equation (screening only), and total bilirubin, ALP, GGT, AST, ALT ≤ 1.5 × ULN. Exclusion Criteria: * Participant must not have any significant acute or chronic medical illness (in the assessment of the investigator). * Participant must not have current or recent GI disease: Any gastrointestinal disease within 3 months of study intervention administration that could possibly affect drug absorption, distribution, metabolism, and excretion (eg, bariatric procedure, history of pancreatitis, uncontrolled nausea or vomiting) in the opinion of the investigator. * Other protocol defined inclusion/exclusion criteria applies.
Interventions
Navlimetostat
DRUG
Locations

Location information is not available.

Technical details
Status
Not yet recruiting
Phase
Phase 1
Study type
INTERVENTIONAL
Sex
Female only
Minimum age
18 Years
Maximum age
55 Years
Healthy volunteers
No
Start date
30.04.2026
Completion date
15.10.2026
Registry ID
NCT07544628
Source
clinicaltrials.gov
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