Influence of Dressings on Skin pH Alterations in Simulated Skin Folds in Healthy Subjects

This study investigates the effect of different dressings on skin pH when applied to a simulated skin fold environment.

This study evaluates the impact of various dressings on skin pH when applied to a simulated skin fold environment. To replicate the occlusive conditions commonly found in skin folds, a non-breathable film will be placed over the dressings, maintaining occlusion for approximately 24 hours. Skin pH measurements will be taken during two separate visits: once before dressing application and again after approximately 24 hours of wear time. Both measurements will be conducted on the same location on the forearms of healthy participants. The goal is to investigate how different dressings influence skin pH under occlusive conditions.

Inclusion Criteria: 1. Written informed consent to participate in this study 2. Healthy men and women between 18-80 years 3. Patient is mentally and physically able to participate in this study 4. Intact skin on the forearms without any signs of irritation 5. Agreed on not to shower or use cosmetic products on the arms the same day as visit 1 and during the study period 6. Agreed not to engage in intense physical activity throughout the study period Exclusion Criteria: 1. Skin disorder of any kind. 2. Known allergy to adhesives or/and any other component(silver) in the investigation devices. 3. Pregnant or lactating women. 4. Presence of tattoos on the forearms. 5. Ongoing medication with antibiotic. 6. Suffer from excessive sweating, hyperhidrosis.