Bidirectional Cohort Study of a Prognosis Model for Acute-on-chronic Liver Failure
Conditions:
Liver Failure
Sponsor: The Second Affiliated Hospital of Chongqing Medical University
trial.available_in:
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Overview
This study constitutes a bidirectional cohort investigation. By collating laboratory parameters and clinical data-including plasma and peripheral blood mononuclear cell (PBMC) analyses-from patients with acute-on-chronic liver failure, it aims to provide a reference framework for predicting prognosis and the occurrence of complications.
Who can participate
Inclusion Criteria:
•Clinical diagnosis of Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF)
Exclusion Criteria:
* age \< 18 years
* extrahepatic organ failure unrelated to ACLF
* active malignancy
* co-infection with other hepatitis viruses or human immunodeficiency virus (HIV)
* prior liver transplantation
* use of immunosuppressants within 6 months before enrollment
* unclear history of antiviral therapy
Locations
1
China (1)
Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University
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