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Намерени 4,436 изпитвания Стр. 16 от 222

Набира участници Фаза 2

MINImising Total Radiation EXposure in Preterm Infants

Neonatal Respiratory Distress Syndrome PreTerm Neonate

Being born too early (preterm birth) is the leading cause of death in children world-wide. In Australia, 97% of very preterm babies who are admitted to Neonatal Intensive Care Units need breathing support after birth to survive. Despite this significant global impact, neonatal clinicians have few tools available to guide breathing support. Currently, the only lung imaging tool that is routinely used in the Neonatal Intensive Care Unit is a chest X-ray. To reduce radiation exposure, chest X-rays are usually only performed one or two times a day. As chronic lung disease in babies who survive preterm birth is increasing, there is an urgent need to develop new ways to monitor the lungs of these fragile babies. Lung ultrasound is a form of imaging that is fast, gentle and radiation free. However, it has not been routinely adopted into caring for preterm babies in most countries. This is because there are no randomised controlled trials that have demonstrated the benefit and safety of using lung ultrasound as the first-line imaging tool in preterm babies. The investigators will conduct a randomised controlled trial to demonstrate that lung ultrasound is a quick, safe and accurate alternative to chest x-rays in preterm babies.

Начало: 13.04.2026 Край: 01.12.2029 Възраст: до 24 г. Диагностика

Australia Western Health, Australia NCT06975189

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CGM-Enhanced DPP to Prevent Type 2 Diabetes in Adults With Prediabetes

PreDiabetes

Prediabetes affects over one-third of adults in the United States, placing them at a higher risk for developing type 2 diabetes and heart disease, which can lead to serious health complications and increased medical costs. Although a program called the Diabetes Prevention Program (DPP) has been shown to lower the risk of diabetes through healthy lifestyle changes, many people find it difficult to stick with these changes over the long term. This study seeks to find out if combining DPP coaching with continuous glucose monitoring (CGM) technology can help people stay on track with their health goals.

Начало: 13.04.2026 Край: 01.03.2028 Възраст: от 18 г.

United States State University of New York at Buffalo NCT07140848

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ATTITUDES, PERCEPTIONS, AND COMPETENCIES TOWARDS ARTIFICIAL INTELLIGENCE IN ORTHOTICS AND PROSTHETICS

Artificial Intelligence Healthcare Professionals Orthotics and Prosthetics Attitude +3

The aim of this study is to analyze, using a mixed-methods approach, the attitudes, perceptions, levels of technology acceptance, and competencies in the use of generative artificial intelligence among healthcare professionals working in the field of orthotics and prosthetics. The study will reveal how the technological transformation in orthotics and prosthetics is perceived by healthcare professionals, and will also identify the professional requirements, barriers, and opportunities for integrating artificial intelligence technologies into practice. In this way, it aims to provide a scientific reference for decision-makers to support the updating of professional education programs in orthotics and prosthetics, the development of institutional policies, and the wider adoption of AI-supported clinical applications.

Начало: 12.04.2026 Край: 30.06.2026 Възраст: 18–65 г.

Turkey (Türkiye) gizem boztas NCT07547293

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Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Cystic Neoplasms and Pancreatic Neuroendocrine Tumors

Endoscopic Ultrasound-Guided Radiofrequency Ablation Pancreatic Neuroendocrine Tumors (pNET) Pancreatic Cystic Neoplasms

The primary aim of this study is to evaluate the technical feasibility and effectiveness of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) in the treatment of pancreatic cystic neoplasms (PCNs) and pancreatic neuroendocrine tumors (pNETs) in patients who are not suitable candidates for surgical treatment or who refuse surgery. EUS-RFA, as a minimally invasive therapeutic option, may potentially reduce the need for intensive imaging surveillance, prevent further progression of these lesions, and serve as a bridging therapy in selected patients for whom surgical intervention may be considered in the future. At the same time, EUS-RFA could contribute to reducing overtreatment, thereby lowering the risk of complications associated with surgical procedures and leading to an overall reduction in healthcare costs. The secondary objectives of the study are to evaluate the safety profile of EUS-RFA, including the incidence and severity of adverse events both in the early postoperative period and during the first year of follow-up, as well as to assess the long-term efficacy of EUS-RFA, including disease progression.

Начало: 11.04.2026 Край: 31.12.2029 Възраст: от 18 г.

Czechia Institute for Clinical and Experimental Medicine NCT07536087

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Efficacy of a Novel Myopia Defocus Spectacle Lens in School-Aged Children

Myopia

This study aims to evaluate the short-term efficacy and safety of a novel, proprietary spectacle lens. Forty myopic participants, aged 6 to 15 years, will be prescribed with the study spectacles for a period of six months. All subjects will be required to attend five scheduled visits. Change in subfoveal choroidal thickness (SfChT), axial length and refraction will be determined.

Начало: 10.04.2026 Край: 01.03.2027 Възраст: 6–15 г.

Hong Kong The Hong Kong Polytechnic University NCT07511387

Набира участници Фаза 1/2

A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

The researchers are doing this study to test the safety of ivonescimab given in combination with standard chemotherapy and stereotactic radiosurgery (SRS) in people with non-small cell lung cancer (NSCLC) that has spread to the brain (brain metastases). The researchers will test different doses of the study drug to find the best dose that causes few or mild side effects in participants. Once the dose is found, the researchers will test it in a new group of participants to see if it is effective in treating their NSCLC brain metastases.

Начало: 10.04.2026 Край: 01.04.2028 Възраст: от 18 г.

United States Memorial Sloan Kettering Cancer Center NCT07535463

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Comparison of the Analgesic Efficacy of Erector Spinae Plane Block in Breast-Conserving Surgery Versus Serratus Anterior Block Combined With Additional Pecto-Intercostal II Block

Pain Management in Breast Surgery Pain After Surgery Regional Anaesthesia

This prospective randomized study will compare the effects of Erector Spinae Plane Block (ESPB) and Serratus Anterior Plane Block combined with Pectoral Nerve Block Type II (SAPB + PECS II) on intraoperative analgesia and postoperative opioid consumption in patients undergoing breast cancer surgery. Seventy patients (ASA I-III, aged 18-75 years) will be randomized into two groups using the sealed envelope method. Ultrasound-guided blocks will be performed preoperatively by the same anesthesiologist, with Group 1 receiving ESPB and Group 2 receiving a combined SAPB + PECS II technique performed through a single skin puncture (single needle entry site) with sequential injections into the two target fascial planes. All patients will undergo surgery under general anesthesia and receive postoperative analgesia via morphine patient-controlled analgesia. Pain scores and total opioid consumption will be statistically analyzed, with p \< 0.05 considered significant.

Начало: 10.04.2026 Край: 31.07.2026 Възраст: 18–75 г.

Turkey (Türkiye) Kayseri City Hospital NCT07368413

Набира участници Фаза 2

Intravesical GEM/DOCE for HR BCG-Unresponsive NMIBC

Bladder Cancer Non-Muscle Invasive Bladder Cancer (NMIBC) Urothelial Carcinoma Carcinoma in Situ (CIS) +7

The goal of this clinical trial is to learn whether a combination of two chemotherapy drugs, Gemcitabine and Docetaxel, can treat high-grade non-muscle-invasive bladder cancer (HG-NMIBC) in adults whose cancer failed conventional BCG therapy. The drugs are given directly into the bladder (intravesically), one immediately after the other. The study will also assess the safety of this treatment. The main questions it aims to answer are: Can this drug combination effectively treat HG-NMIBC that did not respond to BCG and help prevent the cancer from coming back, offering long-term protection? What side effects or medical issues do participants experience during treatment? Researchers will evaluate this non-surgical approach as a potential alternative to bladder removal surgery (radical cystectomy), with the goal of validating it as a bladder-sparing option in this setting. Participants will: * Go through a screening process, including tumor removal and imaging tests * Receive weekly bladder treatments with Gemcitabine followed by Docetaxel for 6 weeks * If the cancer responds, continue with similar once monthly treatments (maintenance therapy) for up to 2 years * Attend regular check-ups, including bladder exams, urine tests, biopsies, and optional quality-of-life surveys * Possibly receive a second 6-week treatment cycle if the cancer returns early * Be followed for up to 5 years to monitor long-term outcomes

Начало: 10.04.2026 Край: 01.01.2033 Възраст: 18–99 г.

United States Michael A. O'Donnell NCT07322263

Набира участници Фаза 1/2

A Study of Mirdametinib in People With Central Nervous System Tumors

Central Nervous System Tumors Glioma

The purpose of this study to find out whether mirdametinib is a safe and effective treatment for Central Nervous System/CNS tumors (glioma and neurohistiocytosis).

Начало: 10.04.2026 Край: 10.10.2029 Възраст: от 18 г.

United States Memorial Sloan Kettering Cancer Center NCT07539441

Набира участници Фаза 1

A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of AZD4954 and Vice Versa in Healthy Adults

Healthy Participants

The purpose this study is to measure the impact of laroprovstat (AZD0780) on the pharmacokinetics (PK) of AZD4954 and the impact of AZD4954 on the PK of laroprovstat in healthy male and female participants.

Начало: 10.04.2026 Край: 09.07.2026 Възраст: 18–55 г.

United States AstraZeneca NCT07513571

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Danicopan PMS in Korea

Paroxysmal Nocturnal Hemoglobinuria

As part of a post-approval commitment, the Korean health authority requests a study to characterize safety and effectiveness in patients who are treated with Danicopan as an add-on to ravulizumab or eculizumab in normal clinical practice settings. This study is designed to assess the known safety profile or identify previously unsuspected adverse reactions and to evaluate the effectiveness of Danicopan under conditions of routine daily medical practice in Korea.

Начало: 10.04.2026 Край: 27.06.2028

South Korea AstraZeneca NCT07457151

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Effects of Low-Intensity Blood Flow Restriction Training on Strength and Kicking Performance in Taekwondo Athletes

Physical Performance Athletic Performance

This study aims to investigate the effects of low-intensity blood flow restriction training (LI-BFRT) on lower-limb strength and kicking performance in taekwondo athletes. Blood flow restriction training is a method that partially restricts blood flow to the muscles during exercise, which may improve performance while reducing training load.

Начало: 10.04.2026 Край: 29.06.2026 Възраст: 16–25 г.

China Shanghai University of Sport NCT07538037

Набира участници Фаза 1

Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes

Diabetes Mellitus

The purpose of this clinical study is to find out how NNC0487-0111 affects, how the body uses insulin (a hormone that helps the body control blood sugar) and how well the pancreas works in people living with type 2 diabetes. There are 2 study treatments. Participants will get either NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Начало: 10.04.2026 Край: 06.12.2027 Възраст: 18–75 г.

Germany Novo Nordisk A/S NCT07535307

Набира участници Фаза 1

A Study Evaluating the Safety and Efficacy of KITE-363 in Relapsed/Refractory Autoimmune Neurologic Diseases

Chronic Inflammatory Demyelinating Polyneuropathy Myasthenia Gravis Multiple Sclerosis

This study will have two Phases: Phase 1a and Phase 1b. The goals of this clinical study are to learn more about the study drug KITE-363, by evaluating its safety, tolerability and efficacy in participants with relapsed/refractory autoimmune neurologic diseases. The primary objectives of this study are: * To evaluate the safety and tolerability of KITE-363 in participants with autoimmune neurologic diseases * To determine the recommended dose for Phase 1b. * To evaluate the preliminary efficacy of KITE-363 in participants with autoimmune neurologic diseases.

Начало: 10.04.2026 Край: 01.06.2029 Възраст: 18–75 г. Лечение

Australia, United States Kite, A Gilead Company NCT07304154

Набира участници Фаза 1

A Study of HDM2024 in Participants With Advanced Solid Tumors

Advanced Solid Tumors

The goal of this clinical trial is to learn if the study drug can work in advanced cancer patients. The main questions it aims to answer are: * Is the drug safe and tolerable ? * Does the drug exhibit antitumor activity ? Participants will receive the study drug once every three weeks, and imaging-based efficacy assessments will be performed every six weeks.

Начало: 10.04.2026 Край: 28.12.2028 Възраст: 18–75 г.

China Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. NCT07539285

Набира участници

Hemodynamic Effects of a Standardized Grape Seed Extract Supplementation

High-normal Blood Pressure

The purpose of this study is to evaluate whether a standardized grape seed extract, compared to placebo, can significantly influence systolic blood pressure (SBP) in individuals with high-normal blood pressure (BP) who are adhering to a low-sodium Mediterranean diet. Additionally, the effects of the grape seed extract on diastolic blood pressure (DBP), other hemodynamic parameters, and the Perceived Stress Score will be assessed.

Начало: 10.04.2026 Край: 30.01.2027 Възраст: 18–70 г.

Italy Indena S.p.A NCT07090876

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qCON/qNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery

Thyroid Surgeries Intraoperative Analgesic Use Anesthesia Depth Monitoring

The aim of this study is to evaluate the effect of using the non-invasive Conox monitor on intraoperative opioid consumption. Additionally, the study aims to assess the impact of Conox monitoring on recovery time, postoperative agitation rate, and pain scores, and to investigate the correlation between qCON and qNOX values and conventional hemodynamic parameters.

Начало: 10.04.2026 Край: 30.06.2026 Възраст: 18–70 г.

Turkey (Türkiye) Kayseri City Hospital NCT07445659

Набира участници Фаза 2/3

Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.

Low Anterior Resection Syndrome Rectal Cancer

The goal of this clinical trial is to learn if antegrade intestinal fluid reinfusion works to prevent low anterior resection syndrome (LARS) in patients with prophylactic ileal stoma. The main questions it aims to answer are: 1. Does it work to prevent LARS by antegrade intestinal fluid reinfusion before performing the ileostomy reversal surgery? 2. Is antegrade intestinal fluid reinfusion more effective than water infusion in preventing LARS. Participants will: 1. Receive either antegrade intestinal fluid reinfusion or antegrade water infusion through ileal stoma based on the standard of care at 1 month after anterior rectal resection, until the ileostomy reversal. 2. Keep a diary of their symptoms.

Начало: 10.04.2026 Край: 10.04.2028 Възраст: 18–75 г.

China Pei-Rong Ding NCT07537998

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Study On Histoacryl Used For Embolization Of Middle Meningeal Artery (MMA) In Chronic Subdural Hematoma (CSDH) (HARMONY)

Subdural Hematoma Subdural Hematoma, Chronic

The aim of the study is to proof the effectiveness of Histoacryl® on preventing recurrence or progression of subdural hematoma after embolization of the middle meningeal artery.

Начало: 10.04.2026 Край: 01.08.2027 Възраст: от 18 г.

Japan Aesculap AG NCT07258069

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Community Connections Through Native Hawaiian Cultural Values to Strengthen Youth Resilience, Health, and Well-Being

Chronic Disease Adolescent Asthma Obesity & Overweight Youth Mental Health +3

The goal of this pilot clinical trial is to learn if a community referral program can improve services for youth with mental health and chronic health conditions in a predominantly Native Hawaiian and Pacific Islander community. The main questions the trial aims to address are: * What is the best way for a community health center to connect youth with community programs rooted in cultural practices and traditions? * Does participation in community programs engage youth and mental health and chronic health outcomes? Participants will: * Participate in a community program for youth that will strengthen connection to 'āina (land) and culture. Programs in the summer are 5 hours per day, 4 days a week, for 4 weeks. Programs in the school-year are 2.5 hours per day, 2 days a week, for 16 weeks. * Take surveys on their demographics, general well-being, mental health, and chronic health conditions they may have at 4 different times: Before the program begins, immediately after the program finishes, 3-4 months after finishing, and 6-8 months after finishing. * Have an adult family member complete surveys on their youth's demographics and general well-being at the same 4 times

Начало: 10.04.2026 Край: 31.08.2028 Възраст: 12–25 г.

United States Waianae Coast Comprehensive Health Center NCT07536256

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