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A Clinical Trial to Investigate the Safety and Efficacy of AP-Brain on Cognitive Function at Varying Dosages in Healthy Middle-aged and Older Adults With Self-reported Memory Problems

Cognition Cognitive Function

The goal of this clinical trial is to safety and efficacy of AP-Brain on cognitive function at varying dosages in healthy middle-aged and older adults with self-reported memory problems. The main question it aims to answer is: What is the effect of AP-Brain at 1 g, 3 g, and 5 g on cognitive function? Participants will be asked to consume AP-Brain at 1 g, 3 g, or 5g, or Placebo and asked to complete memory assessment questionnaires.

Начало: 01.05.2026 Край: 01.10.2026 Възраст: 40–79 г.

Canada Rousselot BVBA NCT07388043

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A Proof-of-concept Study of Ultrasound Stimulation of the Neck to Enhance Anti-shock Efficacy

Shock

The objective of this clinical study is to evaluate the initial efficacy and safety of LIPUS as an adjunct to standard therapy in patients with shock. The investigators will invite patients to participate in a proof-of-concept study investigating the efficacy of neck ultrasound stimulation to enhance anti-shock treatment, involving brief exposure to low-intensity pulsed ultrasound. This study examines whether LIPUS can enhance blood pressure in patients with shock, improve the efficacy of antihypotensive treatment, and reduce the dosage and duration of vasoactive drugs during active pharmacological therapy. By applying LIPUS as an adjunct to conventional treatment in clinical cases of shock, we aim to determine the clinical value of LIPUS and establish a theoretical foundation for developing innovative new therapies for shock.

Начало: 01.05.2026 Край: 01.11.2027 Възраст: от 18 г.

Tao Liu NCT07467798

Предстои набиране Фаза 4

Methadone Rapid Restart

Opioid Use Disorder

The usual treatment for opioid use disorder (OUD) is opioid agonist therapy (OAT) with either methadone or buprenorphine. These treatments are well-established, reduce the risk of fatal overdoses, and are considered the standard approach. However, current methadone guidelines were developed when most people were using heroin, which is far less potent than today's unregulated/illicit fentanyl supply. As a result, people who use fentanyl often need higher doses to feel stable. Because methadone must be started at low doses and increased slowly, it can take weeks before someone reaches an effective dose. This process becomes even longer when doses are missed, since treatment often needs to be restarted at a lower level. The Methadone Rapid Restart is a newer strategy designed to take ongoing fentanyl use into account. Early clinical experience and modelling suggest that many people who use fentanyl have high opioid tolerance and may be able to return to their previous stable methadone dose even after several missed days, without added safety risk. This approach has shown promise in small clinical settings, but it is not yet known whether it provides better outcomes than the standard methadone titration used today. This study will be testing whether this protocol to help rapidly restart people on Methadone is acceptable for patients and use the learning to guide a subsequent larger clinical trial.

Начало: 01.05.2026 Край: 01.03.2027 Възраст: от 19 г.

Canada Pouya Azar NCT07546396

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Evaluation of Myocardial Performance Index in Cases of Fetal Anemia: A Prospective Study

Fetal Anemia Fetal Echocardiography

To Evaluation of myocardial performance index in cases of fetal anemia

Начало: 01.05.2026 Край: 01.05.2028

Assiut University NCT07551232

Предстои набиране Фаза 4

Efficacy and Safety of Triple Therapy With Dulaglutide, SGLT2 Inhibitors, and Finerenone in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease

T2DM (Type 2 Diabetes Mellitus) CKD - Chronic Kidney Disease

The purpose of this study is to evaluate whether adding dulaglutide to the combination therapy of Sodium-Glucose Co-Transporter 2 Inhibitors(SGLT2i) and finerenone can provide additional kidney protection and safety for Chinese adults with Type 2 Diabetes Mellitus(T2DM) and Chronic Kidney Disease(CKD). Eligible participants will be adults with T2DM and mild-to-moderate CKD who have been receiving SGLT2 inhibitor plus finerenone for at least 3 months on the basis of maximum tolerated dose of renin-angiotensin system inhibitor (RASi). Participants will be randomly assigned to either continue the original regimen or to receive add-on therapy with dulaglutide.The study will last for 26 weeks, with participants required to attend scheduled visits for efficacy and safety assessments at Week 13 (±1 week) and Week 26 (±1 week, final visit).

Начало: 01.05.2026 Край: 01.07.2027 Възраст: от 18 г.

First Affiliated Hospital of Wannan Medical College NCT07537088

Предстои набиране Фаза 1

Phase I Clinical Study of NouvNeu001 Injection for the Treatment of Moderate-to-Advanced Parkinson's Disease in Patients Who Have Previously Undergone Deep Brain Stimulation or Deep Brain Nucleus Lesioning Surgery

Parkinson's Disease (PD)

This clinical trial is designed to evaluate the safety, tolerability and preliminary efficacy of a single injection of NouvNeu001 (Human Dopaminergic Progenitor Cells Injection) in patients with Parkinson's Disease who have previously undergone deep brain stimulation or deep brain nucleus lesioning surgery.

Начало: 01.05.2026 Край: 01.07.2031 Възраст: 18–70 г.

China iRegene Therapeutics Co., Ltd. NCT07550374

Предстои набиране Фаза 2

Role of Intravenous Calcium to Decrease Blood Loss During Intrapartum Cesarean Section

Post Partum Haemorrhage Cesarean Section Surgery

To determine the effectiveness of prophylactic intravenous calcium chloride administered after cord clamping in reducing postpartum blood loss during intrapartum cesarean section.

Начало: 01.05.2026 Край: 01.12.2026 Възраст: 18–45 г.

Pakistan Pak Emirates Military Hospital NCT07550413

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AI Algorithm-Informed Biopsy for Prostate Cancer Detection With Indeterminate and Low-Risk Prostate MRI Lesions

Prostate Cancer

Use of AI algorithm for PCa detection is feasible, and AI-informed biopsies (AI-targeted and perilesional biopsy) improves csPCa detection in patients with indeterminate MRI lesions and in patients with low-risk MRI lesions and high-risk clinical features.

Начало: 01.05.2026 Край: 01.01.2029 Възраст: от 40 г.

University of Arkansas NCT07231627

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Vital Signs Blood Pressure Trial

Cardiovascular Diseases Hypertension Blood Pressure

The purpose of this study is collect subject vitals with a blood pressure cuff, electrocardiogram (ECG), and photoplethysmogram (PPG). This data can then be used to develop a reliable, accurate, noninvasive, and continuous blood pressure monitoring device.

Начало: 01.05.2026 Край: 30.09.2026 Възраст: 18–64 г.

Stanford University NCT06272318

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Individualized Care Perceptions of Patients Receiving Outpatient Chemotherapy: A Qualitative Study

Cancer Patients Care Chemotherapy

The purpose of this observational study is to learn how people receiving chemotherapy in a clinic without staying overnight (outpatient) feel about the care they receive. The study focuses on individualized care, which means nursing care that is tailored specifically to each person's unique needs, values, and lifestyle. Background: Cancer treatment often involves chemotherapy (medicine used to kill cancer cells). While these treatments help fight the disease, they can also cause side effects like nausea or tiredness, which affect daily life. Nurses play a key role in helping people manage these effects. This research aims to understand how "individualized care" helps participants feel valued and supported during their treatment journey. The study aims to answer these key questions: How do participants describe their experiences with nursing care? What are the specific needs and expectations of these individuals for care that feels personal to them? How does personalized care affect their ability to manage symptoms and follow their treatment plan? Scope and Setting: This study will take place at the Yalova Training and Research Hospital within the Outpatient Chemotherapy Unit. The research will be conducted between May 1, 2026, and April 1, 2027. Method and Participants: The researchers plan to interview 10 to 20 participants who are over 18 years old and receiving treatment at the clinic. The final number of participants will be decided when the researchers find that no new information or themes are being discovered in the interviews (a stage called "data saturation"). Participants will: Take part in a private, one-on-one interview with a researcher. Answer open-ended questions about their thoughts and feelings regarding their nursing care. Allow the interview to be voice-recorded to ensure all information is captured accurately. Spend approximately 30 to 45 minutes sharing their personal experiences. Privacy and Ethics: Participant privacy is a top priority. All personal information and voice recordings will be kept strictly confidential. In the final report, fake names (aliases) will be used so that no one can be identified. Participants can choose to leave the study at any time. The study follows international ethical rules to protect the rights of every participant.

Начало: 01.05.2026 Край: 01.04.2027 Възраст: от 18 г.

Turkey (Türkiye) University of Yalova NCT07536945

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Effect of Scanning Technology on the Accuracy of Digitally Customized Intraradicular Attachments

Scanning Devices

This study aims to evaluate the accuracy of intra-radicular attachments fabricated by direct scanning using three different scanners in vivo. The primary outcome will be the accuracy of the fabricated attachments, while secondary outcomes will includepatient-reported comfort during procedure of taking intraradicular attachment conventional impression and direct scanning.

Начало: 01.05.2026 Край: 01.08.2026 Възраст: 18–65 г.

October 6 University NCT07403851

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Rehabilitation Interventions After Cardiac Surgery in Older Adults

Cardiac Surgery Postoperative Rehabilitation Kinesiophobia

This randomized controlled trial aims to investigate the effects of foot massage and kinesio taping on functional performance and kinesiophobia in older adults following cardiac surgery. Early mobilization after cardiac surgery is essential for improving recovery outcomes; however, pain, fear of movement (kinesiophobia), and reduced functional capacity may delay rehabilitation in older patients. Participants aged 65 years and older who have undergone cardiac surgery will be randomly assigned to either a foot massage group or a kinesio taping group. The foot massage group will receive daily bilateral foot massage for seven consecutive days, while the kinesio taping group will receive standardized kinesio taping applications to the foot and ankle region during the same period. Functional performance, kinesiophobia, pain intensity, cognitive status, and delirium will be assessed using validated outcome measures, including the Timed Up and Go test, Tampa Scale for Kinesiophobia, Visual Analog Scale, Standardized Mini-Mental Test, and Nursing Delirium Screening Scale. Assessments will be conducted preoperatively and on the seventh postoperative day. The study aims to determine whether non-pharmacological, easily applicable interventions such as foot massage and kinesio taping can enhance functional recovery, reduce fear of movement, and support early mobilization in older adults after cardiac surgery.

Начало: 01.05.2026 Край: 01.02.2027 Възраст: от 65 г.

University of Yalova NCT07548684

Предстои набиране Фаза 4

Bupivacaine Liposome Suspension Administration to Decreasre Peri-procedural Pain in Interventional Radiology (IR) Procedures

Analgesia Assessment

This study evaluates the use of liposomal bupivacaine (Exparel), a long-acting local anesthetic, for peri-procedural pain control in patients undergoing interventional radiology (IR) procedures. Effective pain management during and after IR procedures is important for patient comfort, procedural success, and recovery, yet standard local anesthetics (e.g., lidocaine or bupivacaine HCl) provide relatively short durations of analgesia. Liposomal bupivacaine is an FDA-approved formulation designed to provide extended-release local anesthetic effects over a prolonged period. Its use has been studied in surgical settings, but data in interventional radiology procedures remain limited. This prospective, single-arm quality improvement initiative aims to assess whether incorporation of liposomal bupivacaine into routine procedural care improves patient-reported pain outcomes. Adult patients undergoing IR procedures will receive liposomal bupivacaine administered by the proceduralist as part of standard care. Pain will be assessed using a structured patient-reported outcome survey at multiple time points, including pre-procedure, during the procedure, 1 hour post-procedure, and within 24 hours post-procedure. The survey also captures use of additional analgesic medications within the first 24 hours. The primary outcome is patient-reported pain intensity. Secondary outcomes include post-procedural analgesic utilization. Data will be analyzed descriptively given the exploratory nature and small sample size. Findings from this project may inform future approaches to pain management in interventional radiology and help determine whether longer-acting local anesthetics provide clinically meaningful improvements in patient experience.

Начало: 01.05.2026 Край: 01.07.2026 Възраст: 18–95 г.

Massachusetts General Hospital NCT07535411

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Post-Market Clinical Follow-up (PMCF) Study of the Pitch-Patch for the Augmentation or Reinforcement of the Rotator Cuff

Rotator Cuff Tear Rotator Cuff Tears Rotator Cuff Tears of the Shoulder Rotator Cuff Injuries

This is a clinical investigation study. It will verify the long-term safety and performance of the Pitch-Patch when implanted to reinforce partially repairable rotator cuff tears and used as described by the manufacturer's instructions. The medical device in this study is already on the market and is manufactured by Xiros Ltd. The Pitch-Patch is a single-use polyester prosthesis available in two sizes (30x20mm and 35x25mm). It is reinforced around the perimeter and around each eyelet to provide strength and stability to the device and repair. The study will collect data on patients who meet the entry criteria and have received the device. This is a single-armed study, meaning all patients will have a Pitch-Patch. The total length of the is expected to be 3 years. A minimum of 37 patients will be enrolled into the study. Patients will be enrolled at a study specific follow up visit 2-2.5 years after implant, and data for baseline and other time points prior to 2 years (3month, 6month, and 1 year post surgery) will be collected retrospectively from medical records if available.

Начало: 01.05.2026 Край: 01.12.2029 Възраст: от 16 г.

Xiros Ltd NCT05906004

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The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients

Hypotension on Induction Cardiac Surgery Antihypertensive Agents Anesthesia, Intravenous +1

This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery. The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers) leads to a higher incidence and severity of blood pressure drops and increased need for vasoactive support during the period between anesthesia induction and surgical incision.

Начало: 01.05.2026 Край: 01.12.2026 Възраст: от 40 г.

Turkey (Türkiye) Konya City Hospital NCT07541222

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Study to Assess Prevalence of the Folate Receptor Alpha (FRa) in Adult Female Participants With Ovarian Cancer in Intercontinental (InterCon) Countries

Ovarian Cancer

Epithelial ovarian cancer (OC), including fallopian tube and primary peritoneal cancer, is the deadliest gynecologic malignant neoplasm with a 5-year relative survival of approximately 50%. This study will evaluate the concordance in folate receptor alpha (FRa) immunohistochemistry (IHC) in adult female participants with ovarian cancer. Archived tissue biopsies will be tested for FRa and data from approximately 1,000 participants will be collected. This is a retrospective study and testing will be performed prospectively on archived samples. Participants' charts will be reviewed. No drug will be administered as a part of this study. The duration of the study will be approximately 1 Year. There is no additional burden for participants in this trial.

Начало: 01.05.2026 Край: 01.03.2027 Възраст: от 18 г.

AbbVie NCT07539844

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Relaxing Virtual Reality Use and Blood Glucose Response to Food (ReViR) Study

Post Prandial Blood Glucose Feasibility Pilot Study

This randomized cross-over pilot clinical trial aims to evaluate the feasibility and effect of a relaxing virtual reality (VR) experience on glucose response after white bread consumption, compared to a stress-inducing VR, a VR clinical room, and a real clinical room, in healthy adults. Participants will use a head-mounted display to experience either one of the VR environments, or they will simply sit in an actual clinical room for 15 minutes. After this pre-meal condition, participants will consume 66 grams of white bread within 10 minutes, accompanied by 250 mL of water. They will then continue their assigned pre-meal condition for one hour, followed by an additional hour of sitting in the lab for further assessments. The feasibility of the study will be assessed by calculating: 1) Screening to randomization ratio, 2) Recruitment rate of participants per week, 3) Retention rate, 4) Data Completeness of Finger-Prick Glucose Measurements, and 5) VR intervention tolerability measured by Simulator Sickness Questionnaire (SSQ) score. Postprandial glucose response, stress levels, heart rate, and skin conductance will be assessed at baseline (15 minutes before white bread consumption), immediately before consumption (time 0), and at 15, 30, 45, 60, 90, and 120 minutes post-consumption. Palatability will be evaluated immediately after the meal consumption. Motivation to eat will also be assessed at 0, 15, 30, 45, 60, 90, and 120 minutes. Sense of presence will be measured immediately after VR exposure. Additionally, simulator sickness will be assessed at the beginning of the study and after VR exposure. The results will help us better understand the potential feasibility and benefits of using relaxing VR for postprandial glucose management. These findings will also provide evidence to optimize the design of future definitive randomized clinical trials and enhance the development of VR interventions.

Начало: 01.05.2026 Край: 01.02.2027 Възраст: 18–50 г.

University of Manitoba NCT07541794

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Creation of a Decision Aid for Coronary Anomalies

AAOCA

The coronary arteries supply blood to the heart muscle. Typically, the left coronary artery comes from the left side of the aorta and the right coronary artery comes from the right side. In some cases the coronary artery comes from the wrong side of the aorta. This is known as anomalous aortic origin of a coronary artery (AAOCA). In AAOCA, the major concern is the risk of sudden cardiac death (SCD). The risk of is significantly higher in left AAOCA (L-AAOCA) compared to right AAOCA (R-AAOCA). With the increased risk in L-AAOCA, surgery is recommended to "normalize" the coronary artery position. R-AAOCA has a low absolute risk of SCD. But the risk is higher than the general population. Patients, families, and clinicians must weigh the risks of surgery with the risks of observation. This leads to stress and anxiety around making the management choice. There is no "right" management choice. Shared decision making (SDM) is a strategy of including patient values, preferences, and risk tolerance in medical choices. SDM is particularly useful in settings where there is no clear correct management choice. Decision aids support SDM. No decision aid exists in R-AAOCA. This proposal will create a decision aid and collect pilot data of its implementation. We hypothesize that the use of an aid in R-AAOCA will improve SDM, comfort in the choice, and quality of life. We will engage patients, families, and clinicians to understand their needs to make management choices. This will inform the development of the aid. We will gather feedback on the aid from stakeholders and will revise it. The aid will include data and methods for patients to identify their preferences. When the aid is optimized, we will run a pilot study to evaluate its impact compared to not using the aid. We will evaluate SDM, comfort in the choice made, and quality of life at that time, at 3 months and at 6 months. The pilot data will be used to inform a larger study of the aid. This proposal can be an example how to design decision aids for other congenital heart conditions. This aligns with the AHA's mission of improving lifelong health of the whole person. By improving SDM , patients can feel more confident in their choice and relieve anxiety from the diagnosis. Overall, this proposal supports a shift to patient-centered care with a focus on improving meaningful lifelong outcomes.

Начало: 01.05.2026 Край: 30.03.2029 Възраст: 10–35 г.

United States Vanderbilt University Medical Center NCT07544979

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Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients

Sarcoma, Bone Sarcoma, Soft Tissue Gait Disorder

The goal of DEEPGAIT study is to determine how serious walking problems are for pediatric cancer patients who have had orthopedic surgery, how they change over time, and what can be done to help. Healthy participants without cancer will also be included in this study in order to better understand the difference in walking problems between the 2 groups. DEEPGAIT is a long term study that uses advanced tools-including 3D motion capture, muscle sensors, force plates, and wearable devices-to take a detailed look at how these patients move. Their results are compared to healthy children of the same age and sex. PRIMARY OBJECTIVES * Characterize gait deficits in pediatric cancer patients 1 year following orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis. * Identify personal, disease, treatment and environment risk factors for gait deficits in pediatric cancer patients 1 year following orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis. SECONDARY OBJECTIVES * Build a library of broadly representative normative reference values to generate age- and sex-matched z-scores to quantify frequency, severity and progression of gait deficits among pediatric cancer patients in relation to healthy controls. * Characterize the changes of gait parameters in pediatric cancer patients with or without gait deficits 1 year after orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis, up to 5 years after surgery. * Identify personal, disease, treatment and environment risk factors for trajectories of gait deficits in pediatric cancer patients with or without gait deficits 1 year after orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis, up to 5 years after surgery.

Начало: 01.05.2026 Край: 01.01.2032 Възраст: 5–20 г.

United States St. Jude Children's Research Hospital NCT07502885

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Study of Hyaluronic Acid Used With Gum Surgery to Treat Gum Recession in Adults

Gingival Recession, Mucogingival Surgery

Gingival recession is a common condition in which the gum tissue recedes, exposing the root surface of the tooth. This can lead to tooth sensitivity, higher risk of root decay, and aesthetic concerns. A commonly used surgical treatment is the coronally advanced flap combined with a connective tissue graft (CAF + SCTG), which aims to cover the exposed root and improve gum health. Hyaluronic acid (HA) is a naturally occurring substance in the body that plays an important role in wound healing. It may help improve tissue repair, reduce inflammation, and enhance healing after surgery. This study aims to evaluate whether the use of hyaluronic acid (hyaDENT BG®) in addition to standard surgical treatment improves clinical outcomes in patients with gingival recession. Participants will be randomly assigned to receive either standard treatment alone or standard treatment with hyaluronic acid. The main outcome is the proportion of sites with complete root coverage after 12 months. Additional outcomes include healing, gum tissue improvement, patient-reported pain and discomfort, and aesthetic results. The study also includes a laboratory component to investigate how hyaluronic acid affects cells involved in gum healing.

Начало: 01.05.2026 Край: 01.09.2027 Възраст: от 18 г.

Portugal Universidade do Porto NCT07529340

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