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Inhaled Nitric Oxide for Prevention of Postoperative AKI in High-Risk Cardiac Surgery Patients

Cardiac Surgery Associated - Acute Kidney Injury Cardiac Surgery With Cardiopulmonary Bypass

The goal of this clinical trial is to learn if giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in patients who are at high risk of developing this complication. AKI is a serious problem after heart surgery and can lead to longer hospital stays, higher costs, and increased risk of death or long-term kidney disease. Currently, there is no effective medicine to prevent AKI after heart surgery. The main questions it aims to answer are: * Does inhaled nitric oxide reduce the chance of developing AKI within 7 days after heart surgery compared to placebo? * Does inhaled nitric oxide help preserve kidney function up to 90 days after surgery? Researchers will compare inhaled nitric oxide (the device is turned on) to a placebo (the same device is connected to the breathing circuit but not turned on, so no nitric oxide is given). The device panel is covered so that both participants and the research team do not know who receives active treatment or placebo (double-blind). Participants in this study will: * Have the nitric oxide device connected to their breathing circuit during heart surgery; they will receive either active nitric oxide or no nitric oxide (device off) * Provide blood and urine samples to test kidney function during and after surgery * Be followed for 90 days after surgery to monitor kidney health and any side effects

Начало: 30.04.2026 Край: 31.12.2028 Възраст: от 18 г.

China Shanghai Zhongshan Hospital NCT07544147

Предстои набиране

A Pilot Study to Evaluate the Ability of Lactoferrin to Modulate Iron Homeostasis and Exercise Performance in Exercising Females

Iron Deficiencies Low Ferritin Iron Deficiency Exercise Performance of Fit Athletes

This randomized, double-blind, active-controlled trial will evaluate the effects of human lactoferrin supplementation combined with low-dose iron on iron status, aerobic performance, and lactate metabolism in exercising women with low ferritin. Approximately 30 healthy, menstruating women aged 18-45 years with serum ferritin \

Начало: 30.04.2026 Край: 30.04.2027 Възраст: 18–45 г.

United States Lindenwood University NCT07546591

Предстои набиране

Italian Multicenter Experience With Radioreceptor-assisted Therapy (PRRT)

Pheochromocytomas Paragangliomas

This multicenter retrospective Italian study evaluates the efficacy and safety of PRRT in patients with advanced, unresectable or metastatic pheochromocytomas and paragangliomas (PPGL). Data from \~210 patients treated between 2000 and 2024 will be analyzed. The primary endpoint is disease control rate (DCR). Secondary endpoints include progression-free survival (PFS), overall survival (OS), and prognostic factors.

Начало: 30.04.2026 Край: 30.04.2028 Възраст: от 18 г.

Italy Azienda USL Reggio Emilia - IRCCS NCT07538791

Предстои набиране Ранна Фаза 1

Nanobody-Based CD19/CD20 Tandem Dual CAR-T-cell Therapy of Relapsed/Refractory B-Cell Lymphoma

Relapsed/Refractory B-Cell Lymphoma

This is a single arm study to evaluate the safety and efficacy of Nanobody-Based CD19/CD20 Tandem Dual CAR-T-cell therapy for Relapsed/Refractory B-Cell Lymphoma

Начало: 30.04.2026 Край: 01.05.2029 Възраст: 18–75 г.

Affiliated Hospital to Academy of Military Medical Scie NCT07546630

Предстои набиране Фаза 2/3

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

Macular Degeneration Age-Related Macular Degeneration Choroidal Neovascularization Wet Macular Degeneration

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.

Начало: 30.04.2026 Край: 31.07.2028 Възраст: от 50 г.

EyeBiotech Ltd. NCT07496567

Предстои набиране

Exercise, Pain Beliefs, and Activity Patterns in Musculoskeletal Pain

Musculoskeletal Pain - Acute and Subacute Conditions Exercise (EX) Beliefs Activity Level

This observational study aims to investigate the relationship between exercise benefits and barriers, pain beliefs, and activity patterns in individuals experiencing musculoskeletal pain. Participants will complete questionnaires about their pain, exercise habits, and daily activity patterns. The study does not involve any interventions or treatments. The purpose is to better understand how beliefs and perceived barriers influence physical activity in people with musculoskeletal pain, which may help inform future strategies to improve exercise participation and overall well-being.

Начало: 30.04.2026 Край: 01.12.2026 Възраст: 18–65 г.

Istinye University NCT07528807

Предстои набиране Фаза 3

Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)

Non-Arteritic Anterior Ischemic Optic Neuropathy

This is a phase 3, randomized, multicenter, vehicle-controlled, double-masked study to evaluate the efficacy and safety of intranasal cenegermin compared with vehicle control in adult participants with NAION. Approximately 272 participants who meet all eligibility criteria will be randomly assigned in a 1:1 ratio to receive either cenegermin treatment (Group 1) or the vehicle control (Group 2).

Начало: 30.04.2026 Край: 01.09.2027 Възраст: 50–80 г.

Dompé Farmaceutici S.p.A NCT07453888

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IBM Dietary Surveillance Study

Inclusion Body Myositis

The goal of this observational study is to understand how diet may influence the disease characteristics of inclusion body myositis (IBM). Research findings will help determine whether dietary factors could play a role in managing IBM. The study aims to answer the question: Does diet affect the muscle health and functional ability of people living with IBM? Researchers will compare adults with IBM to healthy volunteers aged 40 years and older. This comparison will help to identify which findings are related to normal ageing and which are specific to IBM. Participants will: Attend an initial screening visit at the Manchester Metropolitan University Institute of Sport to confirm eligibility and explain study procedures. Complete four weeks of home-based monitoring, including dietary records, physical activity monitoring, and questionnaires about lifestyle and symptoms. Attend a second university visit for assessments of body composition, metabolism, and muscle function.

Начало: 30.04.2026 Край: 31.12.2026 Възраст: от 40 г.

United Kingdom Manchester Metropolitan University NCT07535996

Предстои набиране Фаза 1

BR101 in Patients With Relapsed/Refractory Multiple Myeloma

Multiple Myeloma (MM)

This study is an open-label, single-arm, dose-escalation and dose-expansion clinical trial designed to evaluate the maximum tolerated dose, safety, pharmacokinetic profile following administration of BR101 injection, and preliminary efficacy in subjects with relapsed or refractory multiple myeloma.

Начало: 30.04.2026 Край: 30.04.2029 Възраст: 18–75 г.

China Cancer Institute and Hospital, Chinese Academy of Medic NCT07537049

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Molecular Imaging of the Underlying Mechanism of Vessel Wall Inflammation Using Positron Emission Tomography (PET/CT)

Abdominal Aortic Aneurysm

This research study is being conducted to test how an imaging drug called 64Cu-DOTA-ECL1i can be used to image an abdominal aortic aneurysm. 64Cu-DOTA-ECL1i is a drug used with an imaging test called a PET/CT (Positron Emission Tomography/Computed Tomography). The aim is to collect data using a new imaging drug called 64Cu-DOTA-ECL1i that may be able to create images of inflammation in the aorta, which is thought to be important in how aneurysms grow and develop and to understand how consistent these scans are across time and what might affect the inflammation.

Начало: 30.04.2026 Край: 30.04.2029 Възраст: от 18 г.

United States University of Pennsylvania NCT07548099

Предстои набиране Фаза 1

A Phase 1 Study of Navlimetostat Tablet Formulations

Healthy Participants

This study aims to compare the PK of Navlimetostat after administration of a wet-granulation tablet versus the dry-granulation tablet formulation in healthy adult female

Начало: 30.04.2026 Край: 15.10.2026 Възраст: 18–55 г.

Bristol-Myers Squibb NCT07544628

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Effect of Scanning Technology on Internal Fit of Digitally Customized Intra-radicular Attachments

Partially Edentulous Jaw

This study aims to evaluate the marginal and internal fit of intra-radicular attachments fabricated by direct scanning using two different intraoral scanners compared to indirect scanning of conventional impressions.

Начало: 30.04.2026 Край: 30.07.2026 Възраст: 18–65 г.

October 6 University NCT07541625

Предстои набиране Фаза 2

A Study in Adults With Desmoid Tumors

Desmoid Tumor

This is an open-label, multicenter, single-arm phase 2 clinical study designed to evaluate the efficacy, safety, tolerability, patient-reported outcomes (PROs), pharmacokinetics (PK), anti-drug antibody (ADA) and pharmacodynamics (PD) of ES014 in adult desmoid tumor patients.

Начало: 30.04.2026 Край: 01.10.2028 Възраст: от 18 г.

China Elpiscience (Suzhou) Biopharma, Ltd. NCT07541430

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Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols

Dental Pulp Necrosis Pulpitis

Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure irrigation (PulpSucker device), and mechanical activation (Easy Clean device), have shown promise in enhancing bacterial reduction within the root canal system. However, their impact on postoperative pain has not been fully explored. This randomized controlled clinical trial aims to compare bacterial reduction and postoperative pain levels in infected root canals using four different irrigation protocols. The study will use metagenomic analysis to evaluate changes in bacterial community composition and the Visual Analogue Scale (VAS) to assess patient-reported pain levels at multiple time points postoperatively.

Начало: 30.04.2026 Край: 15.01.2028 Възраст: 18–60 г.

Egypt Suez Canal University NCT07546773

Предстои набиране Фаза 3

Traditional Chinese Medicine for the Prevention of Radiotherapy-Induced Oral Mucositis (RTOM)

Radiotherapy-Induced Oral Mucositis Stomatitis Oral Mucositis Radiotherapy Side Effects

This is a multicenter, randomized, controlled, prospective clinical trial designed to observe and evaluate the safety and efficacy of Modified Dahuang Huanglian Xiexin Mouthwash for the prevention of radiotherapy-induced oral mucositis (RTOM). Participants will be randomly assigned to receive either the Modified Dahuang Huanglian Xiexin Mouthwash or Placebo Mouthwash. The study aims to assess the preventative effect on RTOM in patients undergoing radiotherapy.

Начало: 30.04.2026 Край: 31.12.2027 Възраст: 18–70 г.

Union Hospital, Tongji Medical College, Huazhong Univer NCT07543978

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Surgery Plus Systemic Therapy for Liver Cancer With Extrahepatic Metastases

Hepatocellular Carcinoma (HCC) Metastasis

This study will evaluate whether resection of the primary liver tumor, in addition to standard first-line systemic therapy, improves survival in patients with hepatocellular carcinoma that has spread outside the liver but still has a resectable primary intrahepatic tumor. Participants will be randomly assigned to receive either primary tumor resection followed by protocol-allowed first-line immune-based systemic therapy or systemic therapy alone. The primary outcome is overall survival. Secondary outcomes include progression-free survival, objective response rate, disease control rate, immune-related adverse events, postoperative complications, and quality of life.

Начало: 30.04.2026 Край: 30.04.2031 Възраст: 18–75 г.

China Tongji Hospital NCT07537959

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A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users

Nicotine Dependence Tobacco-Related Carcinoma

This clinical trial evaluates a smartphone application (app) called Acceptance and Commitment Therapy (ACT) on Vaping for helping young adults quit using electronic cigarettes (e-cigarettes). E-cigarettes pose numerous risks, particularly to youth and young adults. Addressing the high prevalence of e-cigarette use by young adults requires effective and accessible treatments to support current users to quit. Research shows this group prefers and benefits from newer methods of treatment delivery such as digital interventions. ACT on Vaping is a digital therapeutic intended to deliver behavioral therapy to young adults who vape to motivate and support abstinence from all nicotine and tobacco products. The app contains sessions that promote awareness of cues that trigger tobacco use and teach skills for responding to these triggers in a way that is tailored for the participant's readiness to quit. Receiving access to the ACT on Vaping app may be effective in helping young adults quit vaping.

Начало: 30.04.2026 Край: 15.11.2027 Възраст: 18–30 г.

United States Fred Hutchinson Cancer Center NCT06909500

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Effects of Proprioceptive Neuromuscular Facilitation-Based Lower Extremity Training on Balance, Gait, and Functional Independence in Individuals With Stroke

Stroke Proprioceptive Neuromuscular Facilitation

This study aims to investigate the effects of a proprioceptive neuromuscular facilitation (PNF)-based lower extremity rehabilitation program on balance, gait performance, functional independence, and quality of life in individuals with stroke. Stroke is a leading cause of long-term disability and is commonly associated with impairments in motor control, balance, and walking ability, which negatively affect independence and daily functioning. In this randomized controlled trial, participants with stroke will be randomly assigned to either a PNF-based rehabilitation group or a control group receiving conventional physiotherapy. The intervention will focus on lower extremity PNF techniques to improve motor control, balance, and gait performance. Assessments will be conducted at baseline and at the end of the intervention period. The findings are expected to contribute to the development of evidence-based rehabilitation strategies for individuals with stroke.

Начало: 30.04.2026 Край: 20.08.2026 Възраст: 40–80 г.

Istanbul Medipol University Hospital NCT07525115

Предстои набиране

The Impact of Surgical Procedures on Postoperative Outcomes in Cataract Phacoemulsification and Analysis of Related Factors

Age-related Cataract

The goal of this observational study is to evaluate the location of phacoemulsification tip measured by intraoperative OCT during cataract surgeries and its impact on early postoperative changes of cornea and visual acuity. The main question it aims to answer is: In patients with age-related cataracts undergoing phacoemulsification, does the location (supracapsular, iris-lens diaphragm, or endocapsular) of the phaco tip affect postoperative corneal changes and visual acuity at early postoperative stage? Eyes having phacoemulsification for cataracts will receive intraoperative OCT imaging to evaluate the location of the phaco tip during surgery, and corneal changes and visual acuity will be measured postoperatively.

Начало: 30.04.2026 Край: 30.06.2027 Възраст: 50–90 г.

Zhongshan Ophthalmic Center, Sun Yat-sen University NCT07550907

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A Study of Lanadelumab in Teenagers and Adults With Hereditary Angioedema (HAE) in the Kingdom of Saudi Arabia

Hereditary Angioedema (HAE)

Hereditary angioedema (HAE) is a rare condition. It causes sudden swelling under the skin and inside the body, like in the belly, throat, or genitals. This swelling happens because of a temporary leak in blood vessels but does not cause itching or hives. HAE is classified based on the amount of a protein in the blood called C1 inhibitor (C1INH): HAE with normal C1INH levels (HAE-nC1INH) and HAE with limited or insufficient C1INH levels (HAE-C1INH); HAE-C1INH can be divided into Type 1, with low levels of C1INH, and Type 2, in which the protein is there, but does not work properly. This study will concentrate on people with HAE-C1INH Type 1 or 2 who have received Takhzyro® (lanadelumab) as prophylactic treatment for at least half a year (6 months). Prophylactic means that treatment is given to prevent the happening of HAE attacks. The main goal of the study is to see how well Takhzyro® works in everyday life to reduce the condition's activity after 6 months of treatment, or 12 months (if data is available). This will be measured by checking the change of the HAE activity from before treatment to after 6 months of treatment. The study design will permit a study follow-up of up to 12 months following the index event (i.e. date of first dose administration of Takhzyro®) unless the patient discontinues the index treatment, dies or is lost to follow-up within this timeframe. Chart abstractions will only occur once patients have at least 6 months' duration between the index event date and the date of chart abstraction initiation. Other goals are to find out how a person's quality of life changes after using Takhzyro® for 6 months, how often they had attacks before and after treatment and to learn which factors may have an impact on the treatment. The study will only look at data already existing in the participants' medical records. No treatment will be given as part of the study.

Начало: 30.04.2026 Край: 31.05.2026 Възраст: от 12 г.

Saudi Arabia Takeda NCT07263685

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