Търсене на изпитвания

Активни:

Намерени 4,781 изпитвания Стр. 18 от 240

Набира участници

Sauna for Offline Connections and Interactive, Authentic Living

Loneliness

This pilot trial will test an intervention (sauna visits) targeting reductions in loneliness in adults aged 19-22 years. Participants will: * Visit a sauna in San Francisco once per week for 2 hours by themselves or with a friend, for 8 weeks total * Complete online surveys throughout their participation The main question this pilot trial aims to answer are: * To what extent do participants find the study design acceptable? * To what extent do participants complete the weekly sauna visits? * To what extent do participants complete the weekly online surveys?

Начало: 20.04.2026 Край: 30.03.2027 Възраст: 19–22 г.

United States University of California, San Francisco NCT07223099

Набира участници Фаза 4

Upadacitinib Versus Infliximab as Second-Line Treatment for Acute Severe Ulcerative Colitis（UPRISE）

Acute Severe Ulcerative Colitis

This clinical trial aims to evaluate the comparative efficacy and safety of upadacitinib versus infliximab as second-line treatments for acute severe ulcerative colitis, addressing the following key questions: (1) Can upadacitinib as a second-line therapy effectively induce remission in acute severe ulcerative colitis with efficacy non-inferior to infliximab? (2) What adverse reactions may occur with upadacitinib in the treatment of acute severe ulcerative colitis? Researchers will also compare the efficacy of upadacitinib with that of corticosteroids to assess its therapeutic effect. Participants will be assigned to either the upadacitinib group (receiving upadacitinib extended-release tablets 45 mg once daily for 8 weeks, followed by 30 mg once daily) or the infliximab group (receiving an initial dose of 5 mg/kg, with additional doses at week 2, week 6, and every 8 weeks thereafter at the same dose). The treatment duration is 3 months, with outpatient visits for examinations and tests every two weeks. Patients will record their bowel movements and symptoms such as abdominal pain, and undergo colonoscopy, ultrasound examinations, and blood tests at specified time points.

Начало: 20.04.2026 Край: 01.11.2028 Възраст: 18–85 г.

China Xijing Hospital of Digestive Diseases NCT07550673

Набира участници

Analgesic Efficacy of Quadro-Iliac Plane Block Versus Erector Spinae Plane in Total Hip Arthroplasty

Analgesic Efficacy Quadro-Iliac Plane Block Erector Spinae Plane Block Total Hip Arthroplasty

This study aims to compare the Quadro-Iliac Plane Block versus Erector Spinae Plane Block after total hip arthroplasty.

Начало: 18.04.2026 Край: 01.10.2026 Възраст: от 18 г.

Egypt Tanta University NCT07537036

Набира участници

Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia

Sublingual Caffeine Recovery Time Postoperative Agitation +2

This study aims to evaluate the efficacy of sublingual caffeine in reducing recovery time and incidence of postoperative agitation in elderly patients undergoing general anesthesia.

Начало: 18.04.2026 Край: 30.08.2026 Възраст: от 65 г.

Egypt Cairo University NCT07536568

Набира участници

Prediction of Rectus Femoris Graft Size in ACL Reconstruction

Anterior Curciate Ligament

This study aims to develop and validate a predictive model for estimating the diameter of a quadrupled rectus femoris tendon graft used in anterior cruciate ligament (ACL) reconstruction. By analyzing patient anthropometric characteristics and intraoperative tendon measurements, we aim to identify reliable predictors of graft size to improve preoperative planning and surgical decision-making.

Начало: 18.04.2026 Край: 30.08.2026 Възраст: от 18 г.

Turkey (Türkiye) Samsun University NCT07538245

Набира участници

The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness

Muscle Wasting in Critically Ill

The goal of this clinical trial is to study how whole-body electrical stimulation combined with amino acid intake affects muscle health in ventilated ICU patients. The main questions to answer are: * Does electrostimulation improve the balance of muscle protein in ICU patients? * Does combining electrostimulation with amino acid help build muscle and prevent muscle loss? Researchers will compare three groups of patients: 1. Sham electrostimulation (no current applied) + the standard nutrition 2. Electrostimulation + the standard nutrition 3. Electrostimulation + a 20g amino acid bolus Participants will: * Receive either real or sham electrostimulation * Get their standard nutrition or a 20g amino acid bolus * Have marked amino acids given through an IV * Have blood samples taken to measure the amino acids and glucose in the blood * Undergo ultrasound of the upper arm to measure the blood flow

Начало: 18.04.2026 Край: 01.12.2027 Възраст: от 18 г.

Netherlands Wageningen University NCT07430969

Набира участници

The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women

HIV Menopause Cardiovascular (CV) Risk Carotid Arteriosclerosis +1

Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap. The goal of this observational study is to address this knowledge gap by looking at the role of menopause on cardiovascular disease risk factors such as insulin resistance, hypertension, hyperlipidemia, and carotid atherosclerosis using previously collected data. The investigators will look at underlying causes for cardiovascular diseases worsening in menopausal women with HIV by looking at the role of increased inflammation in the body and whether this is altered by weight. The investigators achieve this by enrolling participants who are willing to undergo a whole body MRI.

Начало: 17.04.2026 Край: 01.03.2030 Възраст: от 18 г.

United States University of California, San Francisco NCT07284082

Набира участници

Feasibility of HPV Self-Collection Kits for Cervical Cancer Screening

Cervical Cancer HPV Infection

This study is testing and implementing an equity-focused, community-based intervention that improves women's access to cervical cancer screening and adherence to follow up after an abnormal result. The study's objective is to assess and compare the feasibility of different methods of distributing at-home HPV testing kits for cervical cancer screening among individuals who are under-screened.

Начало: 17.04.2026 Край: 15.01.2028 Възраст: 25–65 г.

United States Washington University School of Medicine NCT07453459

Набира участници Фаза 2

Becotatug Vedotin (MRG003) in Previously Treated Advanced Hepatocellular Carcinoma

Hepato Cellular Carcinoma (HCC)

This study will evaluate the efficacy and safety of Becotatug vedotin, MRG003, in previously treated advanced hepatocellular carcinoma (HCC).

Начало: 17.04.2026 Край: 14.04.2029 Възраст: от 18 г.

China Fudan University NCT07536789

Набира участници

Radiofrequency Endometrial Ablation or Uterine Artery Embolization for Treatment of Adenomyosis-related Abnormal Uterine Bleeding

Abnormal Uterine Bleeding Due to Adenomyosis (Disorder)

The present study aims to compare the efficacy (menstrual blood loss, pain, quality of life) and the safety (complications, recovery) of each conservative intervention (RFA, UAE) versus hysterectomy for the treatment of adenomyosis-related abnormal uterine bleeding, up to 2 years

Начало: 17.04.2026 Край: 01.05.2029 Възраст: 30–50 г.

France University Hospital, Bordeaux NCT07195305

Набира участници

Poi for Mama: a Pilot to Improve Maternal Microbiome and Gestational Diabetes Risk

Gestational Diabetes Mellitus (GDM) Pregnancy

This investigator-initiated, non-randomized pilot study evaluates the effect of daily consumption of fermented poi on the maternal microbiome and gestational diabetes risk during pregnancy. Fifty pregnant participants between approximately 12 and 24 weeks of gestation will receive one pound of poi daily for four weeks, accompanied by culturally tailored nutrition education delivered via secure text messaging. Changes in vaginal, oral, and rectal microbiome composition, diet quality, gestational diabetes diagnosis, and pregnancy-related outcomes will be assessed and compared with matched controls derived from an existing cohort. This study aims to inform the feasibility and design of a larger culturally grounded dietary intervention for gestational diabetes prevention.

Начало: 16.04.2026 Край: 31.01.2027 Възраст: от 18 г.

United States University of Hawaii NCT07446205

Набира участници Фаза 2

Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

Central Nervous System Cancer Brain Metastases

Adult patients with primary or secondary central nervous system malignancies will be invited to undergo a baseline \[C-11\]-CS1P1 PET scan and a follow-up scan within 24 months of the baseline scan (preferably within 6-months post-treatment).The study will describe patterns of tracer uptake in tumors and normal brain and explore how these patterns relate to MRI findings, treatments received, and clinical outcomes.

Начало: 16.04.2026 Край: 30.06.2033 Възраст: от 18 г.

United States Washington University School of Medicine NCT07462507

Набира участници Фаза 1

Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy

Cerebrovascular Disorders Acute Cerebrovascular Disease

The purpose of this study is to determine the safety and feasibility of using inhaled nitric oxide (iNO) in patients undergoing intra-arterial mechanical thrombectomy (blood clot extraction or IAMT) for treatment of acute ischemic (non-bleeding) stroke (AIS).

Начало: 16.04.2026 Край: 01.12.2028 Възраст: 18–80 г.

United States Wake Forest University Health Sciences NCT05871606

Набира участници Фаза 2

A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

Myasthenia Gravis, Generalized

The purpose of this study is to evaluate the pharmacodynamic (PD) effect, safety, and tolerability of Povetacicept in participants with generalized myasthenia gravis (gMG).

Начало: 16.04.2026 Край: 02.03.2029 Възраст: 18–80 г.

United States Vertex Pharmaceuticals Incorporated NCT07501702

Набира участници Фаза 1/2

A Study to Investigate the Safety of DSP-3077 After a Unilateral Eye Injection in Male and Female Participants 18 Years of Age or Older With Retinitis Pigmentosa

Retinitis Pigmentosa

The Goal of this study is to evaluate the safety, tolerability, and clinical responses following single dose of DSP-3077. Study enrolls both male and female patients in 3 cohorts with each cohort defined by visual acuity (VA) criteria and dose level of DSP-3077. Each cohort will include 4 participants.

Начало: 16.04.2026 Край: 31.10.2032 Възраст: от 18 г.

United States Sumitomo Pharma America, Inc. NCT06891885

Набира участници

EEG Abnormalities in Adult ICU Patients With High Risk of Delirium

Delirium in the Intensive Care Unit

The purpose of this study is to assess the prevalence of EEG abnormalities on Ceribell POC EEG in adult medical, surgical, and cardiovascular ICU patients with high risk of delirium

Начало: 16.04.2026 Край: 30.09.2027 Възраст: от 18 г.

United States Ceribell Inc. NCT07485244

Набира участници Фаза 1/2

A First-in-Human Study of CKD-703 in Advanced Solid Tumors and Non-Small Cell Lung Cancer

Advanced Solid Tumors Non-Small Cell Lung Cancer

This is a Phase 1/2a open-label multicenter study to evaluate the safety, efficacy, and pharmacokinetics of CKD-703 in Advanced c-Met Expressing Solid Tumors, and in MET-Amplified and c-Met Overexpressing Non-Small Cell Lung Cancer. CKD-703 is composed of a c-Met-targeting monoclonal antibody (mAb) coupled to a cytotoxic payload consisting of the anti-microtubule drug monomethyl auristatin E (MMAE); thus, CKD-703 is a novel ADC offering a highly targeted approach with potential improvement of efficacy while reducing off-target effects for patients with NSCLC and other cancers.

Начало: 16.04.2026 Край: 01.12.2029 Възраст: от 19 г.

United States Chong Kun Dang Pharmaceutical NCT07439094

Набира участници Фаза 2/3

A Clinical Study Evaluating Licaminlimab for Dry Eye Disease

Dry Eye Disease (DED)

The primary objective of this study is to evaluate the efficacy and safety of the topical ophthalmic administration of licaminlimab as compared to vehicle in participants with Dry Eye Disease and a specific genotype.

Начало: 16.04.2026 Край: 01.12.2026 Възраст: от 18 г.

United States Oculis NCT07548632

Набира участници

Early Pelvic Floor Physical Therapy for Women Undergoing Pelvic Radiation for Gynecologic Malignancies

Cervical Cancer Radiation Therapy Complication Pelvic Floor Disorders

This is a single arm phase II study in which 28 patients who will be undergoing definitive pelvic external beam radiation therapy for cervical cancer will receive pelvic floor physical therapy 4 weeks after completing radiation therapy.

Начало: 16.04.2026 Край: 16.04.2030 Възраст: от 18 г.

United States University of Cincinnati NCT07447895

Набира участници Фаза 1

Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia

RPS19 Deficient Diamond-Blackfan Anemia

Brief summary The goal of this clinical trial is to learn if APR-2020 is safe and can help treat Diamond-Blackfan Anemia (DBA) in adolescents and children. The main questions it aims to answer are: * Is APR-2020 safe and well tolerated? * Does APR-2020 modify or correct an underlying genetic condition which causes DBA? * Does APR-2020 reduce or eliminate the need for blood transfusions and/or restore certain blood counts affected by DBA? Participants will: * Take the drug one time as an infusion. * Undergo two rounds of a cellular harvest procedure in which their own cells will be used in the manufacturing of their own participant-specific product. * Initially return to the clinic for two years of follow up at increasingly sparse intervals.

Начало: 16.04.2026 Край: 01.09.2028 Възраст: 2–18 г.

United States Apriligen, Inc. NCT07476183

1 … 16 17 18 19 20 … 240