Search trials – HealthDB

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Намерени 4,781 изпитвания Стр. 182 от 240

Not yet recruiting

Validation of Remote Photoplethysmography (rPPG)-Derived Cardiovascular Parameters Against Standard Clinical Measurements and Risk Scores in a Community

Dyslipidemia Angina (Stable) Coronary Artery Disease (CAD) Heart Disease +2

The goal of this observational study is to evaluate whether a contactless camera-based technology, called remote photoplethysmography (rPPG), can accurately measure cardiovascular parameters and estimate cardiovascular risk in adults aged 30 years and older living in a community setting in Semanan, Jakarta. This study aims to determine if rPPG can be used as a simple and accessible tool for early cardiovascular screening. The main questions it aims to answer are: 1. Do cardiovascular parameters measured using rPPG (such as blood pressure, heart rate, and cardiac workload) agree with standard clinical measurements? 2. Do cardiovascular risk estimates generated by rPPG (such as ASCVD risk and Framingham heart age) correspond to risk calculations obtained using conventional clinical and laboratory methods? Researchers will compare results obtained from rPPG-based facial video scans with results from standard medical assessments, including blood pressure measurements, heart rate evaluation, and laboratory tests for cholesterol levels, to determine the level of agreement and accuracy. Participants will: 1. Undergo a short facial video scan (approximately 30-60 seconds) using an rPPG-based system 2. Receive standard clinical assessments, including blood pressure and heart rate measurements 3. Provide basic health information (such as age, sex, smoking status, and treatment history) Undergo simple laboratory testing for cholesterol levels This study is expected to help determine whether rPPG can be used as a reliable, non-invasive, and scalable screening tool for cardiovascular risk in community and primary healthcare settings.

Начало: 23.04.2026 Край: 30.12.2026 Възраст: от 30 г.

Indonesia Tarumanagara University NCT07502703

Not yet recruiting Phase 1/2

Vebectotamab Vedotin Combined With Pucotelimab in the Treatment of Locally Advanced Laryngeal Carcinoma

Head & Neck Cancer

This is a prospective, single-arm, Phase II clinical trial designed to evaluate the efficacy and safety of vibecotamab combined with putelimab in the treatment of locally advanced laryngeal carcinoma.

Начало: 23.04.2026 Край: 23.04.2031 Възраст: 18–80 г.

Tang-Du Hospital NCT07538206

Not yet recruiting

Group Reading and Oral Exercise Program for Older Adults

Oral Frailty Depression Sarcopenia Physical Function Decline

Depression is common among older adults and is often associated with declines in physical and oral health. Non-pharmacological, community-based interventions are needed to support both mental and physical well-being. This study examines the effects of a program combining group-based reading activities and oral exercises in community-dwelling older adults. Participants are randomly assigned to either an intervention group, which receives the six-week program, or a control group receiving general oral health education. The study evaluates whether the intervention can improve physical and oral function, enhance psychological resilience (grit), and reduce depressive symptoms.

Начало: 23.04.2026 Край: 31.12.2027 Възраст: от 55 г.

Mackay Memorial Hospital NCT07550335

Not yet recruiting

Radiographic External Measurement Technique for TIVAP Placement

Vascular Access Device Catherization

Totally implantable venous access ports (TIVAPs) are commonly used in patients who need long-term intravenous treatment such as chemotherapy, parenteral nutrition, or repeated blood sampling. Correct placement of the catheter tip is important to reduce the risk of complications, including arrhythmia, thrombosis, catheter dysfunction, vessel injury, and infection. Several methods are used to determine catheter tip position during port placement, including fluoroscopy, echocardiography, and chest X-ray. However, some of these methods may require additional equipment, increase procedure time, or may not be available in all hospitals. This study aims to evaluate a simple chest X-ray-based external measurement method to estimate the appropriate catheter length before TIVAP placement. In this method, anatomical landmarks identified on a recent chest X-ray are used to calculate the expected catheter length, which is then applied during the procedure. The main goal of the study is to assess how accurately this method places the catheter tip in the desired anatomical position. Secondary goals include evaluating the rate of optimal tip placement, procedure-related complications, and the relationship between predicted and actual catheter tip positions. If successful, this method may provide a practical, low-cost, and widely applicable technique to improve TIVAP placement in routine clinical practice.

Начало: 22.04.2026 Край: 15.08.2026 Възраст: от 18 г.

Prof. Dr. Cemil Tascıoglu Education and Research Hospit NCT07549035

Not yet recruiting

Visualizing Thought Through Mind Mapping: A Randomized Controlled Trial on Critical Thinking and Problem-Solving Skills Among Nursing Students

Mind Mapping Nursing Students Critical Thinking

This study will be conducted to evaluate the effectiveness of the mind mapping method in enhancing nursing students' critical thinking and problem-solving skills. The study will be conducted using a randomized controlled experimental design. The study will be conducted at the Faculty of Nursing at Gazi University, located in Ankara, the capital of Turkey. The study population will consist of students (n=80) enrolled in the Critical Thinking in Nursing course at the Faculty of Nursing, Gazi University, during the 2025-2026 academic year. The research will be conducted in a randomised controlled experimental design (n=65). All students will be administered the "Demographic Information Form," the "Marmara Critical Thinking Tendencies Scale," and the "Problem-Solving Inventory" as pre-tests. Subsequently, students who volunteer to participate in the study will be selected based on inclusion criteria. The students will be assigned to two separate groups using stratified randomization based on their scale point means. The implementation phase of the study will be conducted over five weeks in the Critical Thinking in Nursing course. The researchers have developed five distinct case studies to be discussed in the Critical Thinking in Nursing course. One case study will be covered each week. The case studies address infection control, medication administration, patient safety and medical errors, ethical issues, and systematic approaches. Different teaching methods will be applied to the experimental and control groups simultaneously during the course's scheduled days and times. The subject of the lesson for that day will be covered in 40-50 minutes. After that, the experimental and control groups will be assigned to two separate classrooms for the remaining part of the lesson. Participants in the control group and those excluded from the study will continue with the course's regular flow under the guidance of the course instructor. During the course, they will cover the subject matter usingthe case analysis methods. In the experimental group, students will be divided into small groups of 4-5 people. Over the course of five weeks, they will create mind maps on a different topic each week. Groups will be given approximately 20-30 minutes to create their mind maps. During this process, groups will be expected to prepare their mind maps in a visual format, either using pen and paper or, if they prefer, various web-based programs. At the end of the allotted time, all groups will present the mind maps they have prepared, and these will be discussed. Once all mind mapping presentations are complete, the final test will be administered at the end of the five weeks. All students will take the "Marmara Critical Thinking Tendencies Scale" and the "Problem Solving Inventory" as the final test. Research data will be analyzed using the Statistical Package for Social Sciences (SPSS) version 23. A significance level of p \< 0.05 will be accepted.

Начало: 22.04.2026 Край: 29.05.2026

Gazi University NCT07548658

Not yet recruiting

High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in High-altitude Pulmonary Edema

High-altitude Pulmonary Edema

This study aims to evaluate whether High-flow Nasal Cannula Oxygen Therapy (HFNC) provides superior respiratory support compared to Conventional Oxygen Therapy (COT) in patients with High-Altitude Pulmonary Edema (HAPE).

Начало: 22.04.2026 Край: 22.04.2029 Възраст: от 18 г.

China Third Military Medical University NCT07536477

Not yet recruiting Phase 4

Evaluation of Pain Treatment After Total Knee Arthroplasty

Pain

The purpose of the study is to characterize opioid use after total knee arthroplasty (TKA).

Начало: 22.04.2026 Край: 30.01.2027 Възраст: 18–80 г.

Vertex Pharmaceuticals Incorporated NCT07538570

Not yet recruiting Phase 1

A Study to Learn How Different Injector Pens Affect the Study Medicine Called Genotropin (Somatropin) Delivery and Taken up Into the Blood in Healthy Adults

Healthy

The purpose of this clinical study is to learn about how different injector pens affect: * how the study medicine (called Genotropin) is delivered into the body and * how the study medicine is taken up into the blood in healthy adults. The study is seeking participants who are: * Aged 18 to 60 years old * Male or female who are healthy as determined by medical assessment * Body-mass index (BMI) of 16 to 32, and a total body weight more than 45 kg. BMI is a way to estimate a healthy body weight for an adult's height. Adults in this study will receive study medicine by a shot under the skin. The study medicine will be given using 2 different injector pens which are medical devices that give a shot under the skin. Blood samples will be taken before and after the shots to look for the study medicine. We will compare the amount of study medicine in the blood between shots from the 2 injector pens. Adults will take part in this study for about 10 weeks including the screening period. They will have to stay at the study clinic for at least 13 days. This includes 2 study periods in total. A follow up phone call will be made 23 to 30 days following the last study period.

Начало: 22.04.2026 Край: 22.07.2026 Възраст: 18–60 г.

Pfizer NCT07542886

Not yet recruiting

Serum GFAP, NfL, VEGF and Clinical Progression in Progressive MS

Multiple Sclerosis

This study aimed to investigate whether the biomarkers GFAP, NfL, and VEGF-recently considered important guides for better understanding the pathophysiology of MS-also serve as indicators of clinical progression in MS.

Начало: 21.04.2026 Край: 05.05.2026 Възраст: 18–60 г.

Ondokuz Mayıs University NCT07535242

Not yet recruiting

A Real-World Study of Long-Term Adherence and Persistence to Inclisiran, Evolocumab, and Alirocumab

Cardiovascular Diseases Atherosclerotic Cardiovascular Disease Hypercholesterolemia, Familial

This study aims to evaluate the long-term adherence and persistence to inclisiran and anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies (mAbs) in real-world clinical practice.

Начало: 21.04.2026 Край: 30.09.2026 Възраст: 18–99 г.

Novartis Pharmaceuticals NCT07543731

Not yet recruiting

Polytrauma Patients and Non-technical Skills

Polytrauma Polytrauma Patients Non-technical Skills

The study aims to examine the experience of anaesthesia residents in approching polytrauma patients at different stages of their training using a phenomenological approach.

Начало: 21.04.2026 Край: 20.06.2026 Възраст: от 18 г.

Turkey (Türkiye) Antalya Training and Research Hospital NCT07550244

Not yet recruiting

Neuromuscular Control and Motor Unit Behavior in Patients With Knee Osteoarthritis

Knee Osteoarthritis (Knee OA)

This study aims to examine the effects of moderate-intensity strength training, performed with or without an unloading knee orthosis (valgus-corrective or sham mode), on muscle function, motor unit behavior, and force modulation in patients with moderate knee osteoarthritis

Начало: 20.04.2026 Край: 31.12.2027 Възраст: 55–75 г.

Kaohsiung Veterans General Hospital. NCT07544693

Not yet recruiting

Investigation of Digital Media Use in Patients Receiving Chemotherapy

Cancer Chemotherapy

This study aims to examine digital media use and eHealth literacy among patients receiving chemotherapy. Digital media has become an important tool for accessing health information, communicating with healthcare providers, and supporting self-management. This observational study will be conducted with adult patients receiving chemotherapy in an outpatient setting. Data will be collected using a sociodemographic information form and the eHealth Literacy Scale (eHEALS). The findings are expected to contribute to a better understanding of digital media use and digital health literacy levels in chemotherapy patients.

Начало: 20.04.2026 Край: 20.05.2026 Възраст: 18–67 г.

Turkey (Türkiye) Fenerbahce University NCT07501871

Not yet recruiting Phase 2

Benmelstobart Plus Anlotinib Combined With SBRT for Patients With Hepatocellular Carcinoma Failing First-Line Targeted Therapy

Hepatocellular Carcinoma (HCC) First-line Targeted Therapy Failure Oligometastatic Hepatocellular Carcinoma Benmelstobart +2

This prospective, single-arm, multicenter Phase II clinical trial aims to evaluate the efficacy and safety of Benmelstobart plus anlotinib combined with SBRT in patients with oligometastatic hepatocellular carcinoma who have failed first-line targeted therapy. Key study questions include: What is the progression-free survival (PFS) for patients treated with this regimen? How do the objective response rate (ORR), disease control rate (DCR), and overall survival (OS) compare? What are the safety and tolerability profiles of the combination therapy? Eligible subjects (after signing informed consent) will receive anlotinib 10mg on days 1-14 every 3 weeks + Benmelstobart 1200mg on day 1 every 3 weeks + SBRT. Treatment cycles will be 3 weeks long, continuing until a protocol-specified treatment discontinuation event occurs. Following treatment completion, subjects will undergo post-treatment safety follow-up and survival monitoring, with tumor progression monitoring conducted post-treatment.

Начало: 20.04.2026 Край: 31.08.2028 Възраст: от 18 г.

China Nanfang Hospital, Southern Medical University NCT07537777

Not yet recruiting Phase 2

A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Abdominal Surgery

Pain After Surgery

This is a multi-center, randomized, double-blind, double-dummy, placebo/active-controlled study. 200 subjects undergoing abdominal surgery under general anesthesia are planned to be enrolled and randomized into the HSK55718 group, morphine group, and placebo group.

Начало: 20.04.2026 Край: 20.04.2027 Възраст: от 18 г.

China Haisco Pharmaceutical Group Co., Ltd. NCT07533786

Not yet recruiting

Predictive Role of Photon Counting Computed Tomography in Acute Coronary Syndrom Patients

Coronary Artery Disease

For patients with severe calcification or complex non-calcified plaques, we investigate wether PCCT can enable non-invasive, in vivo precise differentiation and quantitative measurement of plaque components (e.g., spotty calcification, necrotic core, fibrous tissue). Further we also study wether these quantitative imaging features can independently predict the risk of MACE in the short term and long term

Начало: 20.04.2026 Край: 01.12.2028 Възраст: от 18 г.

China Chinese PLA General Hospital NCT07536607

Not yet recruiting Phase 2

A Phase 2A Study of a Novel Antimalarial Pyrrolidinamide in Adult Patients With Uncomplicated P. Falciparum Malaria

Malaria, Falciparum

The study will evaluate the safety and efficacy of a new antimalarial drug GSK3772701 (a pyrrolidinamide), using different doses and treatment durations, in adult participants with uncomplicated Plasmodium (P.) falciparum malaria.

Начало: 20.04.2026 Край: 22.07.2027 Възраст: 18–65 г.

GlaxoSmithKline NCT07545681

Not yet recruiting Phase 1

Comparing the Extent to Which Two Evolocumab Drug Products Are Made Available in the Body After a Single Subcutaneous Dose.

Healthy Participants

The primary objective of this trial is to evaluate the pharmacokinetics (PK) of two evolocumab drug products in healthy participants.

Начало: 20.04.2026 Край: 08.09.2026 Възраст: 18–60 г.

Amgen NCT07545226

Not yet recruiting

OBPM_PANDA2026: Evaluation of the Performance and Safety of the Aktiia Periodic Optical Blood Pressure Monitoring Device

Hypertension

This study, with N = 85 participants minimum over 3 visits spread over 7 days, has been designed to assess the accuracy and precision of the Blood Pressure and pulse rate values as generated by Aktiia.product-G1-US for up to 7 days after initialization in a cohort of subjects representative of the US population.

Начало: 20.04.2026 Край: 31.12.2026 Възраст: 22–59 г.

United States Aktiia SA NCT07507903

Not yet recruiting

Oral Immunotherapy With Egg in Infants

Food Allergy in Infants

In children allergic to egg, oral immunotherapy (OIT) with egg may accelerate that the children grow out of the food allergy. Children than have a positive oral food provocation with egg with a low threshold, will be offered to start OIT. This means that the child have to ingest a small amount of egg every day. Once a year, the child will undergo a new oral food provocation to investigate if the child is still allergic to egg or not. The age of the children at time of this acquired tolerance will be compared with a historical cohort of children with egg allergy.

Начало: 20.04.2026 Край: 01.12.2036 Възраст: 12–36 г.

Josefine Gradman NCT07540091

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