Търсене на изпитвания

Активни:

Намерени 4,781 изпитвания Стр. 189 от 240

Предстои набиране

Effect of AI Critical Appraisal Training on Critical Thinking in Nursing Students

Healthy

This study is a cluster randomized controlled trial aimed at evaluating the impact of the "AI Critical Thinking Training" teaching method on the critical thinking, AI literacy, and clinical reasoning abilities of undergraduate nursing students. Random allocation methods (such as the coin-tossing method) were used to randomly assign eligible classes as a whole to either the experimental group or the control group. The experimental group received AI critical thinking training (using AI to analyze cases and annotate their errors), while the control group received the same amount of time in traditional case-based teaching. The research tools included the Chinese version of the Critical Thinking Disposition Inventory, the AI Literacy Scale, the Clinical Reasoning Scale, and a standardized case analysis scoring sheet. Data collection was conducted twice, before the experiment (pre-test) and after the experiment (post-test). The protocol was based on mature educational theories, with a clear process and extremely low risk, demonstrating good scientific and feasibility. During the research process, if the participants felt any discomfort, they could immediately request to stop the research and withdraw from the study.

Начало: 07.04.2026 Край: 02.04.2027 Възраст: 18–30 г.

China Xi Cao NCT07538986

Предстои набиране Фаза 2

Nab-Paclitaxel Combined With Local Therapy in Relapsed SCLC

Small Cell Lung Cancer Extensive Stage Small Cell Lung Cancer (ES-SCLC)

This is a prospective, single-arm, investigator-initiated clinical study (IIT) designed to evaluate the efficacy and safety of nab-paclitaxel combined with local radiotherapy for patients with extensive-stage small cell lung cancer (ES-SCLC) whose disease has progressed after first-line treatment. Small cell lung cancer (SCLC) is an aggressive type of lung cancer, and extensive-stage SCLC (ES-SCLC) refers to its advanced stage. For patients whose cancer progresses after first-line treatment, there are very limited effective second-line and later-line treatment options. Commonly used clinical regimens such as topotecan and lurbinectedin only provide modest improvements in tumor response and survival, and often cause severe hematological toxicities (represented by bone marrow suppression). This leaves patients in a persistent dilemma of "insufficient efficacy and limited tolerability", highlighting a clear unmet medical need for better treatment options in this population. Against this background, this study explores a comprehensive treatment strategy using nab-paclitaxel as the chemotherapy backbone, combined with local radiotherapy in eligible patients. Nab-paclitaxel is a nanoparticle albumin-bound form of paclitaxel, with a relatively controllable toxicity profile and manageable administration in clinical practice. Local radiotherapy may create a synergistic effect by improving the tumor immune microenvironment and enhancing local tumor control, with the goal of providing better evidence for a "chemotherapy ± local therapy" combination as a second-line treatment option.

Начало: 06.04.2026 Край: 31.12.2030 Възраст: 18–75 г.

Shanghai Pulmonary Hospital, Shanghai, China NCT07547332

Предстои набиране

New Treatment of Common Wart

Common Warts (Verruca Vulgaris)

this study aims to compare the efficacy and safety of platelet rich fibrin injection versus intralesional vitamin D injection in the treatmentof common warts. PRF, as an autologous biological material , may enhance tissue regeneration and immune response.

Начало: 06.04.2026 Край: 30.12.2026 Възраст: от 18 г.

Egypt Sohag University NCT07543926

Предстои набиране

EFFECTS OF CLINICAL PILATES ON PAIN AND QUALITY OF LIFE IN WOMEN WITH DYSPAREUNIA

Dyspareunia

The aim of this study is to investigate the effects of clinical Pilates exercises on pain, self-esteem, body image, depression, and quality of life in women with dyspareunia. The study addresses dyspareunia as a multifaceted health problem with psychological, social as well as physical implications. it evaluates the effects of pelvic floor-focused clinical Pilates interventions on physiological symptoms and psychosocial well-being. it also demonstrates this approach as effective, safe, and evidence-based method in the treatment of dyspareunia among women in Turkish society.

Начало: 06.04.2026 Край: 20.06.2026 Възраст: 18–55 г.

Turkey (Türkiye) Okan University NCT07540195

Предстои набиране

Cohort of Repeat Donor Experiences (CORE) Study

Health Effects (Ferritin Levels, CRP Levels, iGg Levels, Self-reported Health)

The Plasma Protein Therapeutics Association (PPTA) sponsors the Cohort of Repeat Donor Experiences (CORE) Study. This is a prospective, observational cohort study that will follow Source Plasma donors for up to 2 years during the main study (anticipated to begin in summer 2026) and up to 3 months during the pilot launching in mid-March 2026. This study aims to confirm a lack of negative health effects Source Plasma donors may experience as a result of frequent plasmapheresis. The study will use data obtained through self-report surveys for the duration of the study along with periodic whole blood sample collections to test for CRP, ferritin, and IgG.

Начало: 06.04.2026 Край: 30.04.2029 Възраст: 18–74 г.

United States Westat NCT07543965

Предстои набиране

Effects of Intensive Glycemic Control in the Postoperative Period of Neurosurgical Patients on the Incidence of Surgical Site Infection

Surgical Site Infection (SSI)

Surgical site infections (SSIs) are frequent complications in neurosurgical patients, often worsened by perioperative hyperglycemia. This randomized, controlled trial will compare intensive glycemic control (continuous insulin infusion, 140-180 mg/dL) with standard care (subcutaneous insulin, 81-180 mg/dL) in 544 patients. The primary outcome is SSI occurrence within 90 days post-surgery. Results aim to guide optimal glycemic management for SSI prevention in neurosurgery.

Начало: 05.04.2026 Край: 01.10.2027 Възраст: от 18 г.

University of Sao Paulo NCT07548112

Предстои набиране

Steady-state Bioequivalence Study of Aripiprazole for Injection in Patients With Schizophrenia.

Schizophrenia

The primary objective of this study is to evaluate the bioequivalence of aripiprazole for injection (Test product, 400 mg) compared with Abilify Maintena® (Reference product, 400 mg) at steady state in patients with schizophrenia.his is a multi-center, randomized, open-label, two-period, crossover study. Approximately 116 clinically stable patients will be enrolled and randomly assigned to one of two treatment sequences: Sequence A (Test-Reference) or Sequence B (Reference-Test). In each 141-day study period, participants will receive five injections of either the test or reference product at 28-day intervals to achieve steady-state plasma concentrations. Bioequivalence, safety and tolerability of the study drug will be assessed in this study.

Начало: 05.04.2026 Край: 05.11.2027 Възраст: 18–65 г.

CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. NCT07547384

Предстои набиране Фаза 2

Study to Evaluate the Effect of HT-4253 for the Prevention of Alzheimer's Disease in APOE4 Carriers

Alzheimers Disease

Primary Objectives: To demonstrate that HT-4253 improves the amyloid risk profile by transitioning biomarker-positive APOE4 carriers from a positive, high risk APS2 score to a negative, low risk APS2 score. Secondary Objectives: * To assess the effects of HT-4253 on tau related blood biomarker progression over the study period. * To assess the effects of HT-4253 on amyloid related blood biomarker progression over the study period. * To assess the safety and tolerability of HT-4253 in the UAE population.

Начало: 03.04.2026 Край: 20.08.2027 Възраст: 50–75 г.

United Arab Emirates Halia Therapeutics, Inc. NCT07399171

Предстои набиране

Development and Clinical Validation of Key Technologies for Non-invasive Breath Metabolic Fingerprinting for Large-scale Population Lipid Screening

Hyperlipidemia

This study collects exhaled breath condensate samples from healthy populations and hyperlipidemic populations, analyzes the characteristics of the exhaled metabolic lipid profile for early identification of people with abnormal blood lipids, verifies the feasibility and accuracy of a new gas detection method for screening abnormal blood lipids, and explores a simple, fast, and non-invasive method for screening abnormal blood lipids.

Начало: 02.04.2026 Край: 31.05.2026 Възраст: от 18 г.

Beijing Anzhen Hospital NCT07546162

Предстои набиране

Quality of Life and Functional Outcomes in Laryngeal Cancer Patients

Laryngeal Carcinoma Quality of Life (QOL) Patient Satisfaction Voice Quality +3

Laryngeal squamous cell carcinomas are head and neck malignancies that directly affect both swallowing and voice functions and are associated with a significant deterioration in patients' quality of life throughout the treatment process. The aim of this study is to evaluate quality of life, voice and swallowing functions, pain, anxiety-depression levels, and patient satisfaction at the pre-treatment period and at the 3rd, 6th, and 12th months post-treatment in patients with laryngeal malignancies, using validated questionnaires, in order to: Elucidate the course of functional recovery following treatment, Individualize rehabilitation and follow-up strategies, and Examine the relationship between functional outcomes and oncological survival.

Начало: 02.04.2026 Край: 31.12.2027 Възраст: от 18 г.

Saglik Bilimleri Universitesi NCT07320820

Предстои набиране Фаза 2

MAG-PAIN - MAGnesium for Postoperative Analgesia In the Newly Delivered

Postoperative Pain Quality of Recovery (QoR-15) Pain Prediction Magnesium Sulfate +2

The study aims to investigate whether a commonly used medicine, magnesium, can help reduce pain after a Caesarean section. A total of 150 participants will be included. Their usual medical care will not change, and participation is entirely voluntary. The purpose of the study is to determine whether magnesium can improve pain relief after surgery and support faster recovery and bonding with the newborn. Before the operation, potential participants will receive a text message containing a short questionnaire about their background and their expectations regarding postoperative pain. On the day of surgery, all patients will receive two intravenous lines as part of routine care. Those who participate in the study will be asked to rate how painful this insertion was on a scale from one to ten. The participants will then be randomly assigned to receive either magnesium or a saltwater solution through a 100 ml drip, which is administered after the baby is born. Neither participants nor the clinical staff will know which solution has been given, and no blood samples will be collected. After the procedure, participants will be asked several times about their pain level. During the first three days after the operation, each participant will receive one text message per day with a short questionnaire about their pain, general recovery, and early bonding with their newborn. Fourteen days after the operation, and again three months later, they will receive additional questionnaires similar to the earlier ones. Each questionnaire takes approximately five to seven minutes to complete, and no extra hospital visits are required. Magnesium can cause side effects, but the risks associated with the dose used in the study are low. The most common side effect is a brief burning sensation at the infusion site, which is not harmful. Magnesium is widely used in medical care, including in pregnant patients, and the study team considers the treatment safe. Because the medication is administered after birth, it does not affect the baby and does not increase risks during breastfeeding. All collected information will be handled securely and confidentially. Data will be coded so that individual participants cannot be directly identified, and only the research team will have access to the key linking codes to individuals. Participants have the right to access their data, request corrections, ask for deletion of their information, or limit how their data is used. The study has been approved by the Swedish Ethical Review Authority, and results will be published in a scientific journal without identifying any participant. No financial compensation is provided, but participants are covered by the usual patient and medication insurance. To ensure that the study is conducted correctly, authorized monitors or authorities may compare study data with medical records. These individuals must sign confidentiality agreements. By giving consent to participate, individuals allow this review. All data will be stored according to legal archiving requirements. Participation in the study is completely voluntary. Individuals may withdraw at any time, and if they do, their collected data will be deleted. Their medical care before, during, and after the operation will not be affected by their decision to participate or withdraw.

Начало: 02.04.2026 Край: 31.12.2028 Възраст: от 18 г.

Region Halland NCT07528612

Предстои набиране

Workplace Violence and Safety Perception Among ENT Physicians in Turkey

Workplace Violence Perceived Safety Occupational Health Otolaryngology-Head and Neck Surgery Physicians

This multicenter, cross-sectional survey study aims to evaluate the perceived level of safety and security against workplace violence among otolaryngology-head and neck surgery (ENT-HNS) physicians in Turkey. The study investigates the association between exposure to workplace violence and perceived safety, as well as the adequacy of institutional support mechanisms. Data will be collected through an anonymous online questionnaire distributed nationwide. The findings are expected to contribute to awareness and the development of preventive strategies and institutional safety policies for healthcare professionals.

Начало: 02.04.2026 Край: 01.09.2026 Възраст: от 18 г.

Saglik Bilimleri Universitesi NCT07311629

Предстои набиране Фаза 1

A Study to Evaluate the Safety and Pharmacokinetics of UI087 Compared to Coadministration of UIC202506, UIC202507 and UIC202508 in Healthy Adult Volunteers Under Fasting Conditions

Diabetes Mellitus (Type 2)

This study was an open-label, randomized, single-dose, 2-sequence, 2-period, crossover study to evaluate the safety and pharmacokinetics of UI087 compared to coadministration of UIC202506, UIC202507 and UIC202508 in healthy adult volunteers under fasting conditions

Начало: 01.04.2026 Край: 01.10.2026 Възраст: от 19 г.

South Korea Korea United Pharm. Inc. NCT07548957

Предстои набиране

Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension

Postinduction Hypotension

INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.

Начало: 01.04.2026 Край: 01.12.2026 Възраст: от 45 г.

Germany Universitätsklinikum Hamburg-Eppendorf NCT07538388

Предстои набиране

Evaluation of Tears Naturale® Free and Tears Naturale® II Lubricant Eye Drops

Dry Eye Disease

The purpose of this post-market clinical follow-up (PMCF) study is to describe the effectiveness and safety of Tears Naturale® Free and Tears Naturale® II lubricant eye drops in subjects experiencing dry eye (DE) symptoms.

Начало: 01.04.2026 Край: 01.08.2026 Възраст: от 18 г.

Canada Alcon Research NCT07540884

Предстои набиране

Optimizing Early Nutrition Management of Extremely and/or Very Preterm Infants

Nutrition Intervention Quality Improvement Preterm Infant

A clinical quality improvement bundle on early nutrition supplementation is developed to improving the clinical outcomes (including growth, organ function, and neurodevelopment outcomes) of extremely and/or very preterm infants. This bundle consists of three aspects: individualized and precise human milk feeding, early enteral zinc supplementation, and routine parenteral carnitine supplementation.

Начало: 01.04.2026 Край: 31.12.2029 Възраст: до 1 г.

China Children's Hospital of Fudan University NCT07538999

Предстои набиране

Telerehabilitation in Patients With Elevated Pulmonary Artery Pressure

Elevated Pulmonary Artery Pressure

The goal of this clinical trial is to learn if synchronous telerehabilitation is effective in patients with elevated pulmonary artery pressure identified by echocardiography (systolic pulmonary artery pressure ≥50 mmHg). It will also evaluate the effects of telerehabilitation on exercise capacity, dyspnea, fatigue, functional status, and quality of life. The main questions it aims to answer are: Does synchronous telerehabilitation improve exercise and functional capacity in these patients? Does synchronous telerehabilitation improve dyspnea, fatigue, psychological status, and quality of life? Researchers will compare synchronous telerehabilitation with breathing and posture exercises to see if telerehabilitation provides greater clinical and functional benefit. Participants will: Be randomly assigned to one of 2 groups Follow an 8-week program, 3 times per week, for 30 minutes per session Perform aerobic, endurance, and strengthening exercises by synchronous telerehabilitation, or breathing and posture exercises in the control group Complete assessments before and after treatment

Начало: 01.04.2026 Край: 01.08.2026 Възраст: 18–65 г.

Marmara University NCT07535398

Предстои набиране Фаза 3

Intra-Arterial Tirofiban After Complete Recanalization for Acute Intracranial Large-Vessel Occlusion

Acute Ischemic Stroke Large-vessel Occlusion Endovascular Treatment

The goal of this clinical trial is to learn if immediate intra-arterial tirofiban after complete recanalization can improve recovery in adults with acute ischemic stroke caused by anterior circulation large-vessel occlusion. It will also learn about the safety of this treatment. The main questions it aims to answer are: Does immediate intra-arterial tirofiban after complete recanalization increase the number of participants with good functional outcome at 90 days? Does this treatment increase the risk of symptomatic intracranial hemorrhage or other important bleeding events? Researchers will compare immediate intra-arterial tirofiban with no intra-arterial tirofiban after complete recanalization to see if tirofiban improves recovery and is safe. Participants will: Be enrolled after mechanical thrombectomy achieves complete recanalization Be randomly assigned to receive intra-arterial tirofiban or no intra-arterial tirofiban Receive follow-up assessments during hospitalization and at 90 days

Начало: 01.04.2026 Край: 01.04.2028 Възраст: от 18 г.

China Shandong Provincial Hospital NCT07537933

Предстои набиране

Assessing Two Coenzyme Q10 Products in Men and Women

CoQ10 Blood Levels

The goal of this clinical trial is to compare the relative bioavailability of coenzyme Q10 (CoQ10) from acute administrations of a CoQ10 product designed for enhanced absorption versus a standard CoQ10 product in healthy men and women. Participants will be asked to come to the clinical on five different occasions, including a screening visit (visit 1, -7 days), two test 1 visits (visits 2 and 3, days 0 and 1), and two test 2 visits (visits 4 and 5, days 7 and 8). During the start of each test visit (visits 2 and 4), the participant will consume each study product with water and a standardized breakfast meal. Then, blood samples will be collected over a 10-hour period, and a standardized lunch, dinner, and snacks will be provided. The participant will return to the clinic the next morning for a blood draw 24 hours after the study product ingestion from the previous day. The same procedures will be repeated 7 to 14 days later with the other study product.

Начало: 01.04.2026 Край: 01.07.2026 Възраст: 21–65 г.

United States Midwest Center for Metabolic and Cardiovascular Researc NCT07530250

Предстои набиране Фаза 1

Evaluation of the Safety and Efficacy of Sup19 CAR-T Cells in Patients With Previously Failed CD19-Targeted Therapy or CD19-Weakly Expressed Hematologic Tumors

B-Acute Lymphoblastic Leukemia B Acute Lymphoblastic Leukemia/Lymphoma

Evaluation of Sup19 CAR-T cells in cases where previous CD19-targeted therapy has failed or where CD19 Evaluation of Safety and Efficacy in the Treatment of Low-Grade Hematological Malignancies: A Prospective, Single-Arm Clinical Study Research

Начало: 01.04.2026 Край: 01.11.2027 Възраст: 18–69 г.

China Institute of Hematology & Blood Diseases Hospital, Chin NCT07539610

1 … 187 188 189 190 191 … 240