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Предстои набиране Фаза 2/3

Transcutaneous Electrical Acupoint Stimulation at Jing-Well Points for Disorders of Consciousness

Disorders of Consciousness Due to Severe Brain Injury

Effective treatment options for disorders of consciousness (DoC) remain limited, and available interventions show heterogeneous efficacy. To date, limited evidences support the use of amantadine and transcranial direct current stimulation in this population. Bloodletting puncture (BP) at the hand twelve Jing-Well points (HTWPs) has been traditionally used in China as an empirical therapy for DoC; however, its efficacy has not been established by robust clinical evidence. Transcutaneous electrical acupoint stimulation (TEAS) provides a modern, noninvasive alternative for acupoint stimulation. The Wells-DoC trial, a multicenter, randomized, controlled, open-label study with blinded endpoint assessment, provided preliminary evidence that TEAS applied at the hand twelve Jing-Well points was associated with a numerically higher proportion of consciousness improvement in patients with DoC, although the difference did not reach statistical significance. These findings support the need for further evaluation in an adequately powered randomized controlled trial. The Wells-DoC II trial is a multicenter, randomized, controlled, double-blind clinical trial designed to evaluate the efficacy and safety of TEAS at the twelve Jing-Well points of the hand in patients with DoC. The primary objective of the Wells-DoC II trial is to determine whether TEAS applied at the twelve Jing-Well points of the hand improves consciousness in adults with DoC. The primary endpoint is the proportion of patients achieving consciousness improvement after 14 consecutive days of treatment, compared between the TEAS group and the sham stimulation (placebo control) group. The secondary objectives are to assess the effects of TEAS versus sham stimulation on: (1) changes in Coma Recovery Scale-Revised (CRS-R) scores at 7 and 14 days; (2) change in ABCD model classification at day 14; and (3) functional outcomes measured by the Glasgow Outcome Scale-Extended (GOSE) at 3 and 6 months after enrollment. A total of 160 patients will be recruited over a 28-month period.

Начало: 01.04.2026 Край: 01.12.2028 Възраст: 18–80 г.

China Xijing Hospital NCT07535593

Предстои набиране Фаза 1/2

A Clinica Study of SCTC21C in Participants With Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE)

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of SCTC21C in participants with systemic lupus erythematosus

Начало: 01.04.2026 Край: 01.04.2028 Възраст: 18–75 г.

Sinocelltech Ltd. NCT07538154

Предстои набиране Фаза 3

A Study of Lebrikizumab in Adults With Nummular Eczema

Nummular Eczema

The main aim of the study is to evaluate the efficacy, safety, and tolerability of lebrikizumab treatment in adult participants with Nummular Eczema (NE) who are not adequately controlled with Topical corticosteroids (TCS) or when this treatment is not medically advisable.

Начало: 01.04.2026 Край: 01.02.2029 Възраст: от 18 г.

Almirall, S.A. NCT07542483

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C-3002: Enhancing Cervical Cancer Screening Access and Follow-up Care at 'CASCADE' Clinical Sites in the United States

Human Immunodeficiency Virus (HIV) Human Papillomavirus (HPV) Cervical Cancer Cervical Precancer

The purpose of the CASCADE-3002 project is to improve access to cervical cancer screening among women with Human Immunodeficiency Virus (HIV) receiving care at U.S.-based CASCADE clinical sites. This study will assess the cervical cancer screening cascade and identify multilevel factors that impede access to screening among women with HIV attending Infectious Disease clinics in Georgia and Maryland. In parallel, the study will explore and develop implementation strategies for human papillomavirus (HPV) self-collection to increase screening uptake, adherence, and appropriate clinical follow-up in this population at elevated risk for cervical cancer. Cervical cancer remains a preventable malignancy; however, women with HIV are at substantially increased risk and experience higher rates of cervical cancer compared with women without HIV. The World Health Organization has called for the global elimination of cervical cancer as a public health problem, defined as fewer than 4 incident cases per 100,000 women annually, with targets for vaccination, screening, and treatment coverage. Although the United States has the tools to approach near-elimination, disparities in healthcare access and screening persist, particularly among women with HIV.

Начало: 01.04.2026 Край: 01.05.2027 Възраст: от 25 г.

United States UNC Lineberger Comprehensive Cancer Center NCT07520188

Предстои набиране Фаза 3

A Study Comparing BL-M07D1 With Physician's Choice of Chemotherapy in Patients With HER2-Expressing Platinum-Resistant Recurrent Epithelial Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer

Epithelial Ovarian Cancer Fallopian Tube Cancer Primary Peritoneal Cancer

This trial is a registrational Phase III, randomized, open-label, multicenter study to evaluate the efficacy and safety of BL-M07D1 in patients with HER2-expressing platinum-resistant recurrent epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.

Начало: 01.04.2026 Край: 01.12.2028 Възраст: 18–75 г.

China Sichuan Baili Pharmaceutical Co., Ltd. NCT07545460

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Device for Driving Simulation for the Rehabilitation of Balance and Proprioception

Neurological Disorders Health Adult Subjects

The DriveSim clinical trial investigates a dynamic driving simulator designed to train and assess functional motor and cognitive skills in individuals with neurological disorders. The study addresses a critical need in current rehabilitation practice, where maintaining patient engagement and providing ecologically valid training environments are essential yet challenging. Neurological conditions such as stroke, Parkinson's disease, amyotrophic lateral sclerosis and mild cognitive impairment often result in deficits in balance, proprioception, coordination, attention and motor planning, all of which critically affect daily functioning and driving ability. The novelty of this study lies in the integration of a three-degree-of-freedom motion platform with active steering, customizable haptic and inertial feedback, and adaptive task modules in a virtual urban scenario. This enables controlled, multisensory rehabilitation sessions that combine motor, vestibular and cognitive stimuli in a single system. The primary objective of the trial is to evaluate the safety, usability and feasibility of the DriveSim platform in both healthy individuals and patients with neurological impairment. Secondary objectives include assessing its impact on postural control, trunk and head stability, upper and lower limb motor performance, cognitive functions, perceived stress and fatigue, and quality of life. The study also aims to support the development of adaptive software capable of automatically adjusting task difficulty based on patient performance. By integrating functional tasks such as slalom, speed control, line keeping and reaction tests with customizable sensory feedback, this research has the potential to enhance the ecological validity of rehabilitation and to provide individualized motor-cognitive training. The expected outcome is a more engaging, adaptable and measurable rehabilitation pathway that may improve functional independence and support safer driving-related abilities in neurological populations.

Начало: 01.04.2026 Край: 01.11.2026 Възраст: 18–80 г.

University of Pavia NCT07539272

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The Effect of Mindfulness-Based Self-Compassion Training on Childbirth Fear, Pregnancy Stress, and Comfort in Primiparous Women

Pregnancy Related

The purpose of this study was to determine the effects of mindfulness-based self-compassion training provided to primiparous women on fear of childbirth, pregnancy stress, and comfort. Research Hypotheses H1a: Mindfulness-based self-compassion training provided to primiparous women reduces fear of childbirth. H1b: Mindfulness-based self-compassion training provided to primiparous women reduces pregnancy stress. H1c: Mindfulness-based self-compassion training provided to primiparous women increases comfort.

Начало: 01.04.2026 Край: 01.08.2026 Възраст: 18–45 г.

Turkey (Türkiye) Inonu University NCT07548528

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UNC Tobacco Convenience Store

Health Behavior

The main purpose of this trial is to evaluate the impact of a menthol cigarette ban accompanied by a quit smoking campaign on tobacco purchasing behavior. Investigators will conduct a randomized clinical trial with \~1,185 US adults (ages 21+ years) who currently smoke menthol cigarettes.

Начало: 01.04.2026 Край: 01.04.2028 Възраст: от 21 г.

United States University of North Carolina, Chapel Hill NCT07458607

Предстои набиране Фаза 2

Iparomlimab and Tuvonralimab Injection Combined With SBRT in Patients With Early-Stage Non-Small Cell Lung Cancer

NSCLC

Major objectives to evaluate the efficacy and safety of lparomlimab and Tuvonralimab Injection ((QL1706, an Anti-PD-1/CTLA-4 Combined Antibody)) combined with SBRT in patients with early-stage non-small cell lung cancer.

Начало: 01.04.2026 Край: 31.01.2031 Възраст: от 18 г.

China Tianjin Medical University Cancer Institute and Hospita NCT07379398

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Botulinum Toxin and/or Greater Occipital Nerve Block for Patients With Chronic Migraine

Chronic Migraine Headache OnabotulinumtoxinA Greater Occipital Nerve Block Combination Therapy

Chronic migraine is a debilitating neurological disorder that significantly affects patients' daily functioning, mental health, and quality of life. Management typically includes acute and preventive treatments, but effectiveness can be limited due to medication overuse or delayed onset of action. OnabotulinumtoxinA injections provide proven long-term preventive benefits, while Greater Occipital Nerve (GON) block offers rapid but short-term relief. Although both treatments are used individually, evidence on the combined effect is limited. This randomized controlled trial aims to evaluate the efficacy and safety of combining OnabotulinumtoxinA injections with GON block, assessing improvements in headache frequency, severity, and patient quality of life compared to single therapy.

Начало: 01.04.2026 Край: 01.12.2026 Възраст: от 18 г.

Egypt Beni-Suef University NCT07535723

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AI-Enhanced Wide-Field Endoscopic Fluorescence Mapping of Gastrointestinal Mucosal Permeability in IBD - A Pilot Study in IBD Patients and Controls

Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis) NON-IBD

This pilot study will test a new imaging system that uses fluorescent dye and artificial intelligence (AI) during colonoscopy to measure how "leaky" the lining of the colon is in people with inflammatory bowel disease (IBD). The study will include 70 adults at 3 Canadian hospitals: 60 people with ulcerative colitis or Crohn's disease affecting the colon, and 10 people without IBD who are having colonoscopy for routine colorectal cancer screening or surveillance. During the colonoscopy, participants will receive intravenous fluorescein, and the imaging system will record fluorescence in the colon as the scope is withdrawn. The main goal is to find out whether this method can be used safely during routine colonoscopy and whether it can produce usable measurements of mucosal permeability. The study will also examine whether these measurements are related to standard measures of inflammation seen during endoscopy, in biopsy samples, and in ex vivo Ussing chamber testing at the McMaster site. The control group will help define what normal fluorescence and permeability look like. This study is intended to provide early data on whether this approach could become a useful new way to assess barrier dysfunction in IBD.

Начало: 01.04.2026 Край: 01.02.2027 Възраст: от 18 г.

Hamilton Health Sciences Corporation NCT07546955

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Regular Diet After Colorectal Surgery

Colorectal Diet Habits Surgery Post-operative Care

The goal of this pilot study is to assess the safety and feasibility of regular diet after surgical removal of the colon. The study will enroll patients preoperatively, prior to colon surgery, and will follow participants for up to 30 days. The study hypothesizes that simplifying nutritional recommendations is safe and may improve quality of life.

Начало: 01.04.2026 Край: 31.01.2027 Възраст: от 18 г.

United States Weill Medical College of Cornell University NCT07540845

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Extended Time Window Intravenous Thrombolysis Registry for Acute Ischemic Stroke

Stroke Acute Ischemic Stroke

The EXTEND-IVT Registry is a prospective, multicenter, observational cohort study designed to evaluate the effectiveness and safety of intravenous thrombolysis administered beyond 4.5 hours after last known well in patients with acute ischemic stroke (AIS) in routine clinical practice across China.

Начало: 01.04.2026 Край: 01.12.2029 Възраст: от 18 г.

China Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University NCT07536074

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Triage and Recognition of Acute Aortic Dissection in Chest Pain by Electrocardiogram-Artificial Intelligence

Aortic Dissection Type A Chest Pain

The goal of this prospective multicenter observational study is to learn whether an artificial intelligence model based on electrocardiograms (ECGs) can help diagnose acute type A aortic dissection (TAAD) in adults who come to the emergency department with chest pain or related symptoms. The main question it aims to answer is: Can the AI-ECG model accurately distinguish TAAD from other causes of chest pain in a real-world emergency setting? Researchers will compare the AI model's ECG-based predictions with the final diagnosis confirmed by computed tomographic angiography (CTA), which is the reference standard. Participants will undergo routine emergency ECG testing and subsequent diagnostic evaluation as part of standard care. Clinical and ECG data will be collected from five tertiary hospitals, and the model's diagnostic performance will be assessed across centers.

Начало: 01.04.2026 Край: 01.12.2026 Възраст: 18–80 г.

Shanghai Zhongshan Hospital NCT07536932

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The Comparison Between M-E-BCS and C-O-BCS.

Breast Cancer

This study is a multicenter, open-label, randomized controlled trial. The study aims to evaluate differences in operative efficiency (e.g., operative time), economic effect, surgical safety (e.g., surgical complication rates), postoperative aesthetics (e.g., BREAST-Q scores, Harris scores, SCAR-Q scores and Ueda scores), and oncological safety (e.g., margin status, no local recurrence survival) between patients undergoing M-E-BCS and patients undergoing C-O-BCS.

Начало: 01.04.2026 Край: 31.12.2032 Възраст: 18–70 г.

China Du Zhenggui NCT07539545

Предстои набиране Фаза 1

A Study to Evaluate the Safety and Pharmacokinetics of AD-123 Compared to Coadministration of AD-1231 and AD-1232

Diabetes Mellitus

A Study to Evaluate the Safety and Pharmacokinetics of AD-123 Compared to Coadministration of AD-1231 and AD-1232

Начало: 01.04.2026 Край: 01.05.2026 Възраст: от 19 г.

South Korea Addpharma Inc. NCT07538466

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Transcranial Photobiomodulation Treatment in Patients With Sickle Cell Disease

Sickle Cell Disease

Participants are being asked to take part in this clinical trial, a type of research study, because investigators want to learn more about oxygen usage in the brain. Patients diagnosed with sickle cell disease are at risk for difficulties with thinking and academic skills. The brain requires a consistent supply of oxygen for normal function, but this supply is reduced among patients with sickle cell disease. The development of new treatments to improve cerebrovascular functioning is needed to limit these difficulties. Transcranial photobiomodulation (i.e., light stimulation to the brain) has the potential to improve cerebrovascular and neurocognitive functioning among patients with sickle cell disease.Participants will be selected randomly (like the flip of a coin) to receive either active light therapy or placebo (no active light treatment). Primary Objectives * Measure the participation rate in a study of transcranial photobiomodulation to improve cognitive functioning in a sample of children with sickle cell disease (ages 8- 17 years). * Assess self- and caregiver-reported ratings of feasibility and acceptability. * Evaluate the frequency and nature of side effects associated with transcranial photobiomodulation. Secondary Objectives * To assess the change in cognitive performance associated with transcranial photobiomodulation compared to a sham control condition. * To measure changes in cerebrovascular oxygenation (oxygenated and deoxygenated hemoglobin) following transcranial photobiomodulation compared to a sham control condition.

Начало: 01.04.2026 Край: 01.12.2029 Възраст: 8–17 г.

St. Jude Children's Research Hospital NCT06797583

Предстои набиране Фаза 2

Clinical Trial to Observe the Effects of Tamoxifen on Testosterone Recovery in Medically Castrated Prostate Cancer Patients

Hypogonadism Prostate Cancer

Androgen deprivation therapy (ADT) is a cornerstone therapy in the treatment of curable prostate cancer (PCa). However, ADT often leads to a protracted testosterone recovery period in most men or absence of complete recovery in 10-25% of cases. The hypogonadal state has significant psychosocial and physical side effects. Therefore, limiting ADT effect's duration beyond the prescribed castration period is very compelling to patients and providers alike. Tamoxifen, a well-established selective estrogen receptor modulator, offers a novel and cost-effective approach to accelerate testosterone recovery in men with secondary hypogonadism. This project addresses a critical gap in global cancer care by evaluating Tamoxifen as a viable solution for reducing the burden of delayed testosterone recovery and its associated side effects, particularly in resource-limited settings.

Начало: 01.04.2026 Край: 01.10.2030 Възраст: от 18 г.

Canada University Health Network, Toronto NCT07535905

Предстои набиране Фаза 3

A Clinical Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis

Hyperphosphatemia Patients on Hemodialysis

An open-label, single-arm clinical study of TS-172 in hyperphosphatemia patients on hemodialysis

Начало: 01.04.2026 Край: 30.11.2026 Възраст: от 18 г.

Taisho Pharmaceutical Co., Ltd. NCT07548840

Предстои набиране Фаза 1

A Clinical Study to Evaluate the Absorption, Metabolism, and Excretion of Oral [14C]GS1-144 in Healthy Postmenopausal Female Participants

Healthy Postmenopausal Women Absorption Metabolism Excretion

This is a single-center, non-randomized, open-label, single-dose clinical PK study in healthy postmenopausal female participants.

Начало: 01.04.2026 Край: 31.12.2026 Възраст: 40–65 г.

China Changchun GeneScience Pharmaceutical Co., Ltd. NCT07537231

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