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Предстои набиране Фаза 1

A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers

Obesity & Overweight Type 2 Diabetes

Phase 1 Safety and Relative Bioavailability Study of DWRX5003 in Healthy Adults

Начало: 30.03.2026 Край: 30.08.2026 Възраст: 19–64 г.

South Korea Daewoong Pharmaceutical Co. LTD. NCT07539415

Предстои набиране Фаза 1/2

Aclarubicin Plus Cyclophosphamide, Vincristine, and Prednisone (CAOP) in Patients With Previously Treated Cutaneous T-cell Lymphoma

Cutaneous T-Cell Lymphoma Refractory Cutaneous T-Cell Lymphoma, Relapsed Sezary Syndrome Cutaneous T Cell Lymphoma (CTCL)

Cutaneous T-cell lymphomas (CTCL) are a rare and heterogeneous group of extranidal T-cell lymphomas characterized by skin involvement. Current treatment options for CTCL are limited. Although responses have been demonstrated, their duration is often short, especially in patients with advanced stage disease. Additional treatment options are needed which demonstrate activity in cutaneous and extracutaneous sites. The traditional CHOP regimen (Cyclophosphamide, Hydroxydaunorubicin, Vincristine and Prednisone) has some efficacy for CTCL patients, but due to the cardiotoxicity of anthracyclines, patients can only receive a limited course of treatment. After stopping the regimen, most patients will experience relapse. Aclarubicin, also known as aclacinomycin A, is an anthracycline type of antibiotic with significant anti-cancer properties. Previous studies have shown that aclarubicin only induces histone eviction without causing DNA damage, and it stands out in pre-clinical models and clinical studies, as it potently kills AML cells. Meanwhile, aclarubicin lacks cardiotoxicity, and can be safely administered even after the maximum cumulative dose of either doxorubicin or idarubicin has been reached. Aclarubicin's treatment indications include malignant lymphoma, but actual clinical application experience is limited. The purpose of this study is to determine the maximum tolerated dose, safety and efficacy of aclarubicin combined with cyclophosphamide, vincristine, and prednisone (CAOP) for subjects with relapsed or refractory CTCL.

Начало: 30.03.2026 Край: 31.12.2028 Възраст: от 60 г.

China Shanghai Jiao Tong University School of Medicine NCT07535710

Предстои набиране Ранна Фаза 1

Safety and Efficacy of Metabolically Armed GPC3 CAR-T Cells Injection (Meta10-GPC3) in Patients With Unresectable Recurrent/Metastatic Hepatocellular Carcinoma

Hepatocellular Carcinoma (HCC)

A Study of Metabolically Armed GPC3 CAR-T Cells Injection (Meta10-GPC3) in Patients with Unresectable Recurrent/Metastatic Hepatocellular Carcinoma.

Начало: 30.03.2026 Край: 15.04.2029 Възраст: 19–75 г.

China Zhejiang University NCT07487402

Предстои набиране

COMPARISON OF CLASSICAL AND SYRINGE-FREE TECHNIQUES IN ULTRASOUND-GUIDED CENTRAL JUGULAR VENOUS CATHETERIZATION

Central Venous Catheters/Standards Ultrasonography/Methods Ultrasonography/Standards

During central venous catheterization, both in-plane and out-of-plane techniques can be used. In the in-plane technique, the entire needle can be visualized with ultrasound. In the in-plane technique with a linear probe, the vessel and needle are visualized longitudinally. In the syringe technique, a guide needle attached to a syringe is first inserted into the vein and blood is aspirated, then the catheter is placed through a wire sent into the vein via the needle. This procedure is performed under ultrasound guidance, visualizing the vessels, guide wire, and needle. In the syringe-less technique, the guide wire is placed inside the needle and sent directly into the vein. In this technique, there is no need to draw blood into the syringe to confirm that it is in the vein. The aim of our study is to compare the two ultrasound-guided techniques in terms of procedure time, number of attempts, and complication rates. We expect the syringe-less technique to have a shorter procedure time, fewer attempts, and a lower complication rate.

Начало: 30.03.2026 Край: 01.03.2027 Възраст: 18–85 г.

ALİEMAN NCT07547397

Предстои набиране

Effects of a Targeted Prevention Program on Change-of-Direction Biomechanics and Performance in Elite Female Soccer Players

Anterior Cruciate Ligament Injury

Anterior cruciate ligament (ACL) injuries are common in female soccer and frequently occur during change-of-direction (COD) movements without contact. Biomechanical deficits during these movements are considered important risk factors. This study aims to evaluate the effects of a targeted injury-prevention program on biomechanical movement quality and performance during change-of-direction tasks in female soccer players. Participants will perform a 90° cutting task during which biomechanical movement quality will be assessed using the Cutting Movement Assessment Score (CMAS), while performance will be evaluated using cutting time measured with photoelectric timing gates. Participants will also perform the 505 Agility Test to assess additional change-of-direction performance. In addition, subjective perceptions of functional confidence and performance will be collected using Likert-scale questionnaires. The study will assess whether a structured prevention program integrated into regular training can improve biomechanical movement patterns and change-of-direction performance.

Начало: 30.03.2026 Край: 18.05.2026 Възраст: 13–16 г.

Belgium University of Liege NCT07523178

Предстои набиране Фаза 2

Vebreltinib Plus Chemotherapy as First-line Treatment for MET-overexpressing NSCLC

Lung Neoplasms

To explore the efficacy and safety of vebreltinib plus platinum-doublet chemotherapy as first-line therapy in patients with driver gene-negative, locally advanced or metastatic non-small cell lung cancer (NSCLC) with MET overexpression.

Начало: 30.03.2026 Край: 30.12.2028 Възраст: от 18 г.

China Shanghai Chest Hospital NCT07549061

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Comparison of Serratus Posterior Superior Intercostal Plane Block and Rhomboid Intercostal Block for Postoperative Analgesia Following Breast Cancer Surgery With Axillary Lymph Node Dissection

Breast Cancer Lymph Node Dissection Postoperative Pain Mastectomy

This randomized clinical trial aims to evaluate and compare the analgesic efficacy of the Serratus Posterior Superior Intercostal Plane (SPSIP) and Rhomboid Intercostal Block in patients undergoing Breast Cancer Surgery With Axillary Lymph Node Dissection. The primary outcome is Visual Analog Scale (VAS) during the first 24 hours after surgery. Secondary outcomes include total opioid consumption, requirement for rescue analgesia, block performance time, block-related and systemic side effects (hematoma, pneumothorax, local anesthetic toxicity, vascular puncture, infection), Patient satisfaction assessed using a Likert scale, quality of recovery assessed using the QoR-15 questionnaire.

Начало: 30.03.2026 Край: 30.04.2027 Възраст: 18–65 г.

Antalya City Hospital NCT07536867

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Real-World Study on Efficacy and Influencing Factors of Immunotherapy for Pan-Cancer Lymph Node Metastases.

Malignant Solid Tumors With Lymph Node Metastasis

Lymph node metastasis is a key stage of malignant tumor progression and a core factor affecting the efficacy of immunotherapy. The therapeutic response of lymph node metastases to immune checkpoint inhibitors (ICIs) varies significantly among different cancer types, and the underlying regulatory mechanisms remain unclear. This single-center, retrospective observational study was approved by the Ethics Committee of Sun Yat-sen Memorial Hospital of Sun Yat-sen University (Approval No.: SYSKY-2026-278-01). We plan to enroll no less than 5000 patients with pan-cancer lymph node metastasis who received ICI therapy in our hospital. The efficacy of primary tumors (T) and metastatic lymph nodes (N) before and after immunotherapy will be evaluated based on TNM staging changes, and the objective response rate (ORR) at both levels will be calculated. Patients will be divided into two groups according to the use of β-blockers during immunotherapy to compare the ORR differences, and explore the clinical factors affecting the efficacy of immunotherapy for pan-cancer lymph node metastases. This study aims to provide evidence-based medical basis for formulating individualized immunotherapy strategies for pan-cancer lymph node metastasis.

Начало: 30.03.2026 Край: 01.05.2027 Възраст: от 18 г.

China Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University NCT07540377

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The Aim of the Present Study is to Determine Outcome Predictors in Children Who Were Diagnosed as Acute Disseminated Encephalomyelitis (ADEM).

Acute Disseminated Encephalomyelitis Encephalomyelitis Encephalopathy

The aim of the present study is to determine outcome predictors in children who were diagnosed as acute disseminated encephalomyelitis (ADEM).

Начало: 29.03.2026 Край: 01.04.2027 Възраст: 6–18 г.

Assiut University NCT07540182

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Comparing Game-Based Reward Systems to Support Children's Engagement:

Children

This Randomized Control Trial evaluates the impact of different gamification-based incentive schemes (levels, streaks and their combination) on adherence to target behaviors in children. Participants are randomized into four groups with different types of motivational frameworks.

Начало: 28.03.2026 Край: 01.12.2027 Възраст: 9–12 г.

Charles University, Czech Republic NCT07509489

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Effects of Midwife-guided biırth Affirmation Cards on Labor Process and Experience ın Primigravidas

Duration of Labor Labor Pain Fear of Childbirth Control (Internet Only) +1

The aim of this study is to evaluate the effects of midwife-guided birth affirmation cards on labor duration, pain level, fear of childbirth, perceived control, and perceived support in primigravidas. The study seeks to determine whether this non-pharmacological approach used during labor improves the childbirth experience. Accordingly, the research aims to answer the question: "Do midwife-guided birth affirmation cards affect labor duration and the childbirth experience, including pain, fear, perceived control, and perceived support, in primigravidas?"

Начало: 27.03.2026 Край: 31.08.2026 Възраст: 18–40 г.

Turkey (Türkiye) KTO Karatay University NCT07542392

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Surgical Glove Compression to Prevent Paclitaxel Neuropathy

Paclitaxel-Induced Peripheral Neuropathy Breast Cancer Surgical Glove

This study aims to evaluate the effect of surgical glove compression as a prophylactic method to prevent paclitaxel-induced peripheral neuropathy. Participants will be randomly assigned to two groups: one receiving standard care, and the other receiving prophylactic surgical glove compression. The study will compare the development, severity of neuropathy in the hands and fingers, and its impact on quality of life.

Начало: 26.03.2026 Край: 26.03.2027 Възраст: 18–80 г.

Turkey (Türkiye) Necmettin Erbakan University NCT07504770

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An Initial Experience With the Disposable Celsio Cryocatheter System for Diagnostic and Interventional Bronchoscopy

Lung Cancer (Diagnosis) Interstitial Lung Disease (ILD)

This clinical trial is intended for patients awaiting an interventional bronchoscopy procedure where the use of a cryocatheter is considered. This type of catheter is already used in clinical practice for the treatment of certain types of bronchial obstructions, including tumors, granulomas, and for foreign bodies extractions. This catheter uses extremely cold temperatures offering unique advantages compared to heat-based technologies. Different types of reusable and single-use cryocatheters are actually available on the market. This type of device requires the use of expensive and bulky consoles operating with heavy gas tanks, resulting in high maintenance costs. A Quebec, Canada based company has developed a cryocatheter that combines procedural efficacy with practical considerations in mind. The Celsio cryocatheter operates without a console and is designed to accommodate the bronchscopist through the different types of cryogenic procedures. This study aims to generate meaningful, real-world evidence without interfering with standard clinical care. The collected data will serve to characterize the device's performance profile, identify best practices for its use, and provide data for the design of future prospective comparative studies.

Начало: 23.03.2026 Край: 23.03.2028 Възраст: от 18 г.

Canada Institut universitaire de cardiologie et de pneumologie NCT07539701

Предстои набиране

Validation of Remote Photoplethysmography for Non-Invasive Estimation of Blood Glucose and HbA1c

Diabetes Mellitus Hyperglycaemia (Diabetic) Hyperglycaemia (Non Diabetic) Hypoglycaemia

The goal of this observational study is to evaluate whether a non-invasive facial scan technology using remote photoplethysmography (rPPG) can accurately estimate blood glucose and HbA1c levels in adults living in the community in Jakarta. The study focuses on adults aged 18 years and older, including individuals with or without diabetes. The main questions it aims to answer are: 1. Can rPPG-based facial scan estimates of blood glucose and HbA1c match results from standard laboratory blood tests? 2. How well can rPPG identify individuals with high blood sugar or diabetes risk based on established clinical cut-off values? Researchers will compare results from the rPPG facial scan with standard laboratory measurements of fasting blood glucose and HbA1c to determine how accurate and reliable the technology is for screening purposes. Participants will: 1. Provide basic information such as age, sex, and medical history 2. Undergo a non-invasive facial scan using a smartphone-based system 3. Have a blood sample taken to measure fasting blood glucose and HbA1c 4. Complete all assessments during a single study visit This study aims to determine whether rPPG can serve as a simple, non-invasive, and accessible tool for early detection and monitoring of diabetes in community settings.

Начало: 23.03.2026 Край: 30.12.2026 Възраст: от 18 г.

Indonesia Tarumanagara University NCT07502690

Активно (без набиране)

NOBO Body Odor Control Efficacy Proof-of-Concept Study #1

Body Odor

The goal of this clinical trial is to evaluate the performance of NOBO, a yeast-based fermentate designed to control axillary odor, in controlling axillary odor in healthy male and female adults age 18 - 70 with confirmed self-perception of body odor. The main question it aims to answer is: Does NOBO decrease self-perceived odor of the intervention axilla compared to the placebo axilla at any time point? Researchers will compare the intervention axilla to the placebo axilla to see if there is a difference in self-perceived odor and microbiome. Participants will: * be given a NOBO deodorant spray and a placebo deodorant spray (each assigned to one axilla) * self assess body odor * sample axilla with cotton round for 3rd party odor assessment * sample axilla with a swab for skin microbiome analysis via qPCR * self assess skin irritation

Начало: 16.04.2026 Край: 04.05.2026 Възраст: 18–70 г.

United States Kingdom NCT07547761

Активно (без набиране)

Effectiveness of Superficial Cervical and Clavipectoral Block for Clavicle Surgery

Clavicle Fracture Postoperative Pain Regional Anesthesia Block

This study aims to compare two local anesthesia techniques (nerve blocks) for patients undergoing collarbone (clavicle) fracture surgery. Typically, this surgery uses the "Interscalene Block" (ISB) technique. However, this method carries risks of side effects such as shortness of breath because the nerves controlling the respiratory muscles may also be numbed. As an alternative, researchers want to test a newer combination: the "Clavipectoral Block" (CPB) combined with the "Superficial Cervical Block" (SCB). The researchers want to determine if the new combination (SCB-CPB) provides pain relief as effective as the traditional technique (SCB-ISB), but with improved safety, particularly in maintaining the patient's respiratory stability and heart rate. During the study, patients will be randomly assigned to one of two groups: SCB-CPB Group: Receives a combination of nerve blocks in the collarbone area. SCB-ISB Group: Receives a combination of nerve blocks in the neck area (interscalene). The results of this study are expected to provide a more comfortable and safer anesthesia option for patients undergoing clavicle surgery.

Начало: 16.04.2026 Край: 30.07.2026 Възраст: 20–60 г.

Indonesia Udayana University NCT07548775

Активно (без набиране)

Geriatric Nursing Training Program for Nursing Students

Nurse Training Geriatric Communication Skills EMPATHY İN NURSİNG

This research will be conducted using a parallel randomized controlled trial design to investigate the effects of a nursing education program grounded in Travelbe's Human-to-Human Relationship theory on willingness to work with elderly individuals, empathy levels, and communication skills. The sample group will consist of third-year nursing students at a state university (intervention: 24; control: 24). The Willingness to Work with Elderly Individuals Scale, the Kiersma-Chen Empathy Scale, and the Communication Skills Scale will be used to collect data. The intervention group will receive a six-session nursing education program based on Travelbe's Human-to-Human Relationship theory. A repeated-measures ANOVA will be used to compare the mean scores obtained by the groups on the scales. In addition, independent-samples t-tests will be used for the pre-test and post-test comparisons within groups, and Cohen's d and eta-squared will be used to calculate the effect sizes. The normality distribution of the data will be examined. Parametric tests (One-sample t-test, ANOVA) will be applied to data that show normal distribution, and nonparametric tests (Mann-Whitney U test, Kruskal-Wallis test, Wilcoxon test, Friedman test) will be applied to data that do not show normal distribution.

Начало: 15.04.2026 Край: 29.05.2026 Възраст: до 60 г.

Turkey (Türkiye) Gazi University NCT07543627

Активно (без набиране)

DECisive Intracoronary PHysiology and Imaging in the Evaluation and Reclassification of Non-culprit Lesions in Acute Coronary Syndrome

Coronary Artery Disease Acute Coronary Syndromes (ACS) Optic Coherence Tomography Fractional Flow Reserve

Despite all advances in diagnostic and therapeutic methods over the past century, ischemic heart disease (IHD) remains a leading cause of mortality and morbidity worldwide. IHD develops as a result of reversible or irreversible impairment of myocardial perfusion in acute or chronic settings. This perfusion abnormality most commonly arises from compromise of epicardial coronary artery patency due to stenosis, occlusion, or vasomotor abnormalities. Structural and/or functional alterations in the microcirculation may also contribute to impaired myocardial perfusion. Conditions in which myocardial perfusion is acutely compromised are classified as acute coronary syndromes (ACS), whereas reversible ischemia developing on a chronic basis is evaluated under the umbrella of chronic coronary syndromes (CCS). In the assessment of epicardial (macrovascular) or microvascular pathologies leading to ischemia in CCS, angiography, a macroscopic lumenographic method, is often insufficient. Intracoronary pressure and flow measurements are required to determine the impact of angiographically detected epicardial lesions on coronary blood flow, perfusion pressure, and consequently myocardial perfusion. These measurements are referred to as invasive intracoronary physiology (IIP). Current guidelines recommend that decisions regarding revascularization of intermediate epicardial lesions should be based on IIP. Revascularization guided by IIP is associated with reduced mortality and morbidity, along with a lower stent burden. IIP can be performed using pressure-based, flow-based, or combined strategies. Recent multinational studies indicate that strategies integrating both flow and pressure parameters achieve better clinical outcomes with fewer interventions and reduced stent implantation compared to pressure-only approaches. Indeed, in cases where coronary flow and flow reserve are preserved, abnormalities in pressure parameters alone may not justify revascularization. Nevertheless, lesions deemed not to be associated with reversible ischemia based on IIP may still pose a risk due to plaque erosion/rupture and subsequent thrombotic cascades that can acutely compromise the lumen. Many acute coronary syndromes arise from lesions that are hemodynamically insignificant (i.e., do not affect flow) and unrelated to reversible ischemia in the CCS setting, but which undergo sudden near-total or total occlusion. The histopathological characteristics of any coronary lesion can be evaluated using intracoronary imaging techniques. Intracoronary Optical Coherence Tomography (IC-OCT) is a high-resolution, real-time imaging modality that quantitatively assesses lipid-rich plaque content, evaluates the thickness and stability of the fibrous cap separating this content from the lumen, and provides detailed information regarding minimal lumen area, lesion morphology, surface characteristics, presence of erosion, and plaque vulnerability to rupture. IC-OCT can identify lesions that are hemodynamically insignificant yet may benefit from revascularization and have the potential to cause ACS. Combined evaluation using IC-OCT and IIP enables an integrated assessment of both the relationship with chronic reversible perfusion impairment and the risk of precipitating ACS for each lesion and coronary segment, thereby facilitating optimal revascularization strategies. Despite the available evidence and guideline recommendations in CCS, the use of IC-OCT and IIP in the context of ACS remains limited due to procedural challenges and variability in practical application. These methods are not routinely recommended in guidelines and, in some cases, are even discouraged. However, the optimal strategy for revascularization of non-culprit lesions in ACS remains uncertain, and no consensus has yet been established. Patients with ACS are at increased risk for recurrent events arising from all coronary lesions. Therefore, accurate evaluation and preventive revascularization strategies for these lesions are expected to provide substantial benefit. Our study aims to reclassify and characterize non-culprit lesions in patients with ACS using combined IC-OCT and IIP assessment.

Начало: 14.04.2026 Край: 30.04.2027 Възраст: от 18 г.

Turkey (Türkiye) Istanbul Mehmet Akif Ersoy Educational and Training Hos NCT07548554

Активно (без набиране) Фаза 2

Tofacitinib for Glucocorticoid-Resistant Moderate-to-Severe Thyroid Eye Disease

Thyroid Eye Disease, TED Graves Ophthalmopathy Graves Orbitopathy

Thyroid Eye Disease (TED), also known as Graves' orbitopathy, is an autoimmune condition that causes inflammation and tissue expansion behind the eyes, leading to bulging eyes (proptosis), double vision, and pain. Currently, intravenous glucocorticoids (steroids) are the standard first-line treatment. However, approximately 20-30% of patients do not respond to steroids, or cannot tolerate their side effects. This study aims to evaluate the safety and efficacy of Tofacitinib, an oral medication known as a Janus kinase (JAK) inhibitor, as a rescue therapy for these difficult-to-treat cases. Tofacitinib works by blocking specific signaling pathways (JAK-STAT) that drive inflammation and fibrosis in the eye socket. In this study, patients with moderate-to-severe active TED who are resistant to or intolerant of steroids will receive Tofacitinib tablets (5 mg twice daily) for 24 weeks. The researchers will assess whether the treatment can effectively reduce eye bulging and improve clinical activity scores.

Начало: 13.04.2026 Край: 30.12.2027 Възраст: 18–75 г.

China The First Affiliated Hospital of Xiamen University NCT07547930

Активно (без набиране) Фаза 1

Study on the Mass Balance of [14C]HRS-9190 for Injection in Healthy Participants

Healthy Adult Male

To evaluate the absorption, metabolism and excretion after a single intravenous bolus of \[14C\]HRS-9190 in healthy Participants

Начало: 11.04.2026 Край: 01.05.2026 Възраст: 18–45 г.

China Jiangsu HengRui Medicine Co., Ltd. NCT07494175

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