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Effectiveness of Enzyme Spray Intervention on Thirst Relief in Patients With Endotracheal Intubation.

Thirst

This study addresses the high prevalence (66%-70%) of thirst among intensive care unit (ICU) patients with endotracheal intubation, a symptom associated with oral mucosal dryness, nil per os (NPO) status, high-flow oxygen therapy, and medication effects. Unrelieved thirst may contribute to anxiety, delirium, and unplanned extubation. Current clinical practices, such as cold water or saline sprays, provide only transient relief and may pose aspiration risks. Enzyme-based saliva substitutes, which mimic natural saliva and stabilize the oral environment, show potential benefits; however, evidence in ICU populations remains limited. A single-blind randomized controlled trial (RCT) will be conducted in an ICU of a medical center in southern Taiwan. Eligible participants are adult patients (≥18 years) with endotracheal intubation expected to exceed 24 hours, a baseline thirst intensity score (NRS-I) ≥3, and the ability to communicate. A total of 76 participants will be recruited and randomly assigned in a 1:1 ratio to either the experimental group (enzyme-based oral spray) or the control group (distilled water spray), using sequentially numbered, opaque, sealed envelopes (SNOSE) to ensure allocation concealment. The intervention will be administered following routine oral care within a standardized time window (13:00-15:00). Both solutions will be prepared in identical opaque spray bottles to maintain blinding. The protocol includes 12 sprays per session (approximately 1.56 mL), delivered to four standardized intraoral sites, with outcomes monitored over a 4-hour period. Primary outcomes include thirst intensity (Numerical Rating Scale-Intensity, NRS-I) and thirst distress (Numerical Rating Scale-Distress, NRS-D), assessed at baseline (T0) and at 30, 60, 120, and 240 minutes post-intervention (T1-T4) by blinded outcome assessors. No biological specimens will be collected; data will be obtained from self-reported measures and electronic medical records, with strict de-identification and secure storage procedures. This study is considered minimal risk. Any adverse events, such as discomfort or choking, will result in immediate discontinuation of the intervention. Data will be analyzed using generalized estimating equations (GEE) to evaluate group, time, and interaction effects. The findings are expected to provide evidence-based guidance for improving thirst management, enhancing patient comfort, and optimizing the quality of critical care nursing.

Начало: 10.04.2026 Край: 30.12.2026 Възраст: от 18 г.

Taiwan Yeh,Shiao Feng NCT07533552

Активно (без набиране) Фаза 4

Simultaneous Starting of the 4 Guideline Directed CKD Therapies (RAPID-CKD)

Chronic Kidney Diseases Type 2 Diabetes

The purpose of this study is to determine if starting all four chronic kidney disease therapies at the same time is safe and effective in patients with Type 2 Diabetes and Chronic Kidney Disease. Study hypothesis states that starting all four recommended kidney medications at the same time is safe and effective in reducing albuminuria, a protein in the urine, without a decline in kidney function or increase in potassium levels compared to starting one medication at a time.

Начало: 09.04.2026 Край: 31.03.2029 Възраст: 18–84 г.

United States Baylor Research Institute NCT07547878

Активно (без набиране)

Effects of Developmental Support for Mothers of Infants With Spinal Muscular Atrophy

Spinal Muscular Atrophy Developmental Delay

Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder causing progressive muscle weakness and atrophy. This mixed-methods study aims to provide developmental support to mothers of infants (aged 12-36 months) with SMA Type 1 and to evaluate its impact on infants' developmental outcomes and mothers' developmental knowledge. Participants will include 13 mothers recruited via purposive sampling from a university hospital's Pediatric Chest Diseases Outpatient Clinic. Inclusion criteria require mothers to have infants with SMA Type 1 who are receiving pharmacological treatment and do not have a tracheostomy. Ten mothers will be assigned to the intervention group, and three to the control group. Data will be gathered using quantitative and qualitative tools. Quantitative instruments include a General Information Form, the Ages and Stages Questionnaires (ASQ) and its Social-Emotional version (ASQ-SE) for developmental progress, and the researcher-adapted Caregiver Knowledge of Child Development Inventory (CKCDI). Qualitative data will be collected via "Parental reflections on developmental support" from the intervention group. The intervention consists of a 12-week online developmental support program, held once weekly for 90 minutes. Post-test measurements will be administered to both groups immediately after the intervention, followed by a retention test for the intervention group four weeks later. Finally, prioritizing the children's best interests, the control group will receive a four-session developmental support program after the study concludes.

Начало: 08.04.2026 Край: 01.08.2026 Възраст: 12–36 г.

Turkey (Türkiye) Medipol University NCT07547189

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Superselective Renal Artery Embolization for Renal Angiomyolipoma

Selective Endovascular Embolization of Kidney Artery

To evaluate the efficacy and safety of selective endovascular embolization in the treatment of renal angiomyolipoma (AML). Materials and Methods: A prospective analysis will be conducted on patients who undergo transcatheter renal artery embolization for renal angiomyolipoma. Inclusion criteria will be radiologically confirmed angiomyolipoma based on CT and/or MRI findings and the presence of clinical indications for embolization. The primary outcomes will include the assessment of changes in serum creatinine and hemoglobin levels post-procedure, technical success rates, and the incidence of any complications. Expected Results: Data on patient demographics, tumor characteristics, and procedural outcomes will be collected and analyzed. Conclusion: This study aims to determine whether selective endovascular embolization is a safe and effective treatment modality for renal angiomyolipoma, with the expectation of demonstrating a high rate of technical success while preserving renal function.

Начало: 06.04.2026 Край: 10.05.2027 Възраст: от 18 г.

Russia Botkin Hospital NCT07538908

Активно (без набиране)

COMPARISON OF LARYNGEAL MASK AIRWAY AND TRACHEAL INTUBATION WITH AND WITHOUT TOPICAL LIDOCAINE APPLICATION

Comparison of Airway Management Techniques in Functional Endoscopic Sinus Surgery

The study aims to identify the advantages and disadvantages of each of the three methods of airway management during FESS.

Начало: 01.04.2026 Край: 01.02.2027 Възраст: от 18 г.

Russia St. Petersburg State Pavlov Medical University NCT07548866

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Independent, External, Blinded Retrospective Validation of an AI-based Prognostic Assay in ER-Positive/HER2-Negative Early Breast Cancer

Breast Cancer Early Breast Cancer ER-Positive HER2-Negative Breast Cancer

This retrospective observational study evaluates the prognostic performance of a locked Artificial Intelligence (AI)-based assay in patients with Estrogen Receptor (ER)-positive, Human Epidermal Growth Factor Receptor 2 (HER2)-negative early breast cancer (EBC) from Austrian Breast \& Colorectal Cancer Study Group (ABCSG)-8, with extended follow-up from ABCSG-16 where available. ABCSG will provide digitized hematoxylin and eosin (H\&E) slides and required baseline clinicopathologic variables to Spotlight Medical without outcome data for blinded assay inference. ABCSG will then perform the prespecified statistical analyses linking assay outputs to clinical outcomes.

Начало: 01.04.2026 Край: 31.03.2028 Възраст: 18–80 г.

Austria Spotlight Medical NCT07541703

Активно (без набиране)

Effect of a High-Protein Diet With Meal Replacements on Weight Loss

Obesity & Overweight

The goal of this clinical trial is to learn if a structured high-protein diet with meal replacements can help with weight loss in adults with overweight or obesity. The main questions it aims to answer are: Does this diet help participants lose more body weight? Does this diet improve body composition and blood markers such as glucose and cholesterol? Researchers will compare a structured diet program with meal replacements to a standard low-calorie diet to see if it leads to better weight loss and health outcomes. Participants will: Follow a calorie-restricted diet for the duration of the study Be assigned to either a meal replacement program or a standard diet Attend study visits for body measurements and blood tests Report their feelings of hunger and fullness

Начало: 01.04.2026 Край: 01.07.2026 Възраст: 25–60 г.

Kazakhstan Kazakh Academy of Nutrition NCT07547722

Активно (без набиране)

TearCare MGX™ System With and Without Warming Hold

Meibomian Gland Dysfunction (Disorder)

TearCare is an office-based thermal therapeutic eyelid technology cleared by the US Food and Drug Administration for the treatment of evaporative dry eye disease due to meibomian gland dysfunction. In this randomized study, TearCare procedures using the TearCare MGX System (study device) with the extended Warming hold feature will be compared with TearCare procedures using the TearCare MGX System without the Warming hold (control group).

Начало: 17.03.2026 Край: 01.05.2026 Възраст: от 22 г.

United States Sight Sciences, Inc. NCT07365735

Активно (без набиране) Фаза 4

Analgesic Effect of Superficial Cervical Plexus Block in Postoperative Neck Surgeries

Postoperative Pain

analgesic effect of superficial cervical plexus block by using ultrasound in patients undergoing neck surgeries

Начало: 16.03.2026 Край: 30.10.2027 Възраст: 18–60 г.

Egypt Sohag University NCT07539935

Активно (без набиране) Фаза 1

A Study to Investigate the Effect of AZD5004 on Mitiglinide and Pioglitazone in Healthy Participants

Healthy Participants

The purpose of the study is to assess the effect of AZD5004 on the pharmacokinetics (PK) of mitiglinide and pioglitazone in healthy participants.

Начало: 13.03.2026 Край: 02.07.2026 Възраст: 18–55 г.

Japan AstraZeneca NCT07444424

Активно (без набиране)

Trans-septal Quilting Suturing vs Intranasal Silicone Splinting in Septoplasty

DNS

There is currently little data comparing intranasal silicone splinting versus trans-septal quilted suturing in terms of preventing problems following septoplasty. The purpose of this study is to compare the results of intranasal silicone splinting with trans-septal quilted suturing following septoplasty. After septoplasty, this study will give us a better procedure with fewer adverse effects. Based on the outcomes, this can then regularly be used that specific approach in general practice to treat these specific individuals in an effort to lower their morbidity

Начало: 04.03.2026 Край: 03.06.2026 Възраст: 10–40 г.

Pakistan Shahida Islam Medical Complex NCT07537920

Активно (без набиране) Фаза 1

A Study in Healthy People or Otherwise Healthy With Overweight or Obesity to Compare 2 Formulations of Survodutide Given in Different Ways, Either as a Pre-filled Syringe or a Pen-like Injector

Healthy Obesity

The goal of this study is to find out whether different formulations of survodutide given by different delivery methods is taken up in the body in a similar way. Participants visit the study site regularly. During study visits, the doctors collect information about participants' health. To assess the study endpoints, participants regularly have blood samples taken.

Начало: 03.03.2026 Край: 08.06.2026 Възраст: 18–55 г.

Germany Boehringer Ingelheim NCT07413913

Активно (без набиране)

Design and Validation of a Personalized Preventive System for Adolescents Based on Biological Maturity, Body Composition, and Musculoskeletal Function.

Musculoskeletal Health Adolescent Growth and Development Injury Prevention

This study aims to evaluate the effectiveness of a personalized preventive physiotherapy and exercise program based on biological maturation status in adolescents aged 14 to 15 years. During adolescence, rapid growth and differences in biological maturation can increase the risk of musculoskeletal imbalances, pain, and injuries, especially in physically active youth. However, most preventive programs are designed according to chronological age rather than biological development. Participants will be assessed using non-invasive methods to determine biological maturation, body composition, and musculoskeletal function, including strength, balance, mobility, and postural control. Based on these assessments, participants in the intervention group will receive a 12-week individualized preventive physiotherapy program adapted to their maturation stage, while the control group will continue with their usual school or sports activities without structured intervention. The study will compare changes in musculoskeletal function, body composition, pain perception, and lifestyle-related variables between baseline and post-intervention assessments. The results are expected to provide evidence for a maturation-based preventive approach that can be applied in clinical, school, and sports settings to reduce injury risk and improve musculoskeletal health in adolescents.

Начало: 01.03.2026 Край: 31.12.2027 Възраст: 14–15 г.

Spain University of Alicante NCT07385794

Активно (без набиране)

A Real-World Evidence Study Evaluating the Effects of the Human Optimization Project Protocol on Methylation Biomarkers and Health-Related Quality of Life in Women

Longevity Women's Health

This study looks at whether a daily dietary supplement called HOP Box can improve markers of biological aging and overall health in women. HOP Box contains 19 ingredients selected to support cellular health, metabolism, inflammation, and longevity. Thirty-five women between the ages of 35 and 60 will take the supplement twice a day for 90 days. Researchers will measure changes in biological age using an at-home blood test that analyzes DNA methylation patterns, track sleep quality, heart rate, and heart rate variability using an Oura Ring wearable device, and assess participants' self-reported quality of life using a validated health survey (PROMIS-29). There is no placebo or control group in this pilot study - all participants will receive the supplement and serve as their own comparison over time. The goal is to gather early data on whether HOP Box shows promising health effects in women, which would inform the design of a larger, more rigorous trial in the future.

Начало: 01.03.2026 Край: 25.08.2026 Възраст: 35–60 г.

United States Human Optimization Project NCT07548645

Активно (без набиране)

Impact of Disinfectant Caps on Nosocomial CLABSI

Central Line-associated Bloodstream Infections

In a worldwide, one-day, prospective point-prevalence study, a prevalence of 15.1% for hospital-acquired central line-associated bloodstream infections (HA-CLABSI) was determined in 13,796 patients across 1,265 intensive care units in 75 countries. According to reference data from the National Reference Center for Surveillance of Nosocomial Infections, an average of 1.2 HA-CLABSI episodes per 1,000 central venous catheter days occurred in German intensive care units between 2020 and 2024. Since the mean length of stay for the observed patients was 4 days, this value could be significantly higher for patients with longer stays, such as those undergoing neurological rehabilitation. Besides economic consequences (costs of CLABSI treatment, extended treatment duration), bloodstream infections also have a significant impact on treatment outcomes. Studies show that patients have twice the mortality risk after a bloodstream infection - even after adjusting for disease severity - and that bloodstream infections are associated with longer stays in the intensive care unit and in the hospital. Bloodstream infections occur when pathogenic germs enter the bloodstream. This can happen through entry via wounds (e.g., after trauma), via venous catheters (catheter-associated), or through other infections that spread systemically (e.g., infections in the lungs, abdomen, or urinary tract). To reduce the risk of pathogenic germs entering the bloodstream from venous catheters via the access point, disinfection caps can be used. These caps are pre-treated with 70% isopropanol and packaged sterilely. According to an observational study, the use of such disinfection caps in an oncology clinic significantly reduced the rate of contaminated blood cultures (central venous catheters) from 2.5% (17 of 692) to 0.2% (1 of 470). To reduce the risk of pathogenic germs entering the bloodstream from venous catheters, disinfection caps can be used. As part of quality-improvement measures, the use of disinfectant caps is planned in the neurological intensive care unit. The use of these caps therefore does not constitute a study intervention in the strict sense, but rather the implementation of a new in-house quality standard.

Начало: 01.03.2026 Край: 31.12.2027

Germany BDH-Klinik Hessisch Oldendorf NCT07430215

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Individualized Nursing Care and Frailty Outcomes in Cardiac Surgery

Frail Patient Cardiac Surgical Procedures (Postoperative Population) Patient-centered Care Clinical Outcomes

This study is a randomized controlled trial aiming to compare targeted individualized nursing care with standard care in frail elderly patients undergoing cardiac surgery. The hypotheses of the study are: H1: Targeted individualized nursing care has an effect on the frailty level of frail elderly patients undergoing cardiac surgery. H2: Targeted individualized nursing care affects the factors influencing frailty in frail elderly patients undergoing cardiac surgery.

Начало: 01.03.2026 Край: 30.06.2026 Възраст: от 65 г.

Turkey (Türkiye) SELDA MERT NCT07471945

Активно (без набиране)

Caries Removal Methods and Microbiome Changes

Caries, Dental

Dental caries management approaches may influence not only tissue removal but also the microbial composition within the cavity. However, clinical evidence on how different caries removal methods affect the oral microbiome remains limited. This study aims to evaluate the effects of selective and non-selective caries removal methods on the diversity and composition of the oral microbiome using 16S rRNA gene sequencing. The findings are expected to help identify biologically compatible treatment approaches that effectively reduce pathogenic microorganisms.

Начало: 26.02.2026 Край: 01.08.2026 Възраст: 18–40 г.

Turkey (Türkiye) Nuh Naci Yazgan University NCT07538089

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A Trial to Assess the Pharmacokinetics and Pharmacodynamics of a Novel Synbiotic Oral Supplement for Vaginal Health

Vaginal Health

A randomized, placebo-controlled trial to assess the Pharmacokinetics and Pharmacodynamics of a novel synbiotic dietary supplement for vaginal health.

Начало: 26.02.2026 Край: 26.02.2027 Възраст: 21–60 г.

United States Radicle Science NCT07435350

Активно (без набиране)

Tailored Yoga Therapy for Attention-deficit Hyperactivity Disorder

Attention-Deficit Hyperactivity Disorder Symptoms Attention-Deficit Hyperactivity Disorder

This study will explore the feasibility, acceptability, and potential benefits of a group-based tailored yoga programme designed for adults experiencing symptoms of attention-deficit hyperactivity disorder. The yoga intervention will be compared to an active control (group-based functional movement classes).

Начало: 23.02.2026 Край: 31.12.2026 Възраст: от 18 г.

United Kingdom King's College London NCT07541820

Активно (без набиране)

Impact of Chewing Gum on Bowel Preparation in Patients Undergoing Colonoscopy

Colon Cancer Screening

Colorectal cancer is the second leading cause of cancer deaths that could be prevented in the United States. Colonoscopy is the best test for finding and removing polyps before they turn into cancer. However, many people are hesitant to have a colonoscopy because of the bowel preparation. The preparation can be difficult to tolerate, with patients often struggling to finish it due to the taste, volume, or side effects like nausea and bloating. This can lead to incomplete procedures or discourage people from getting screened at all. Chewing sugar-free gum is a simple, low-cost, and safe intervention that may make the preparation process easier. One study from China found that chewing gum did not change the quality of bowel cleansing, but patients reported that they were more satisfied with the process. No U.S.-based studies have tested this strategy, and no prior research has looked at whether gum chewing has different effects in people using high-volume versus low-volume prep solutions. The investigators will randomize 160 participants to the stated intervention or control using computer-generated 1:1 randomization. Upon completing the study, the investigators will analyze the data. By studying gum chewing during bowel preparation, the investigators hope to find out whether this small change can make bowel prep more tolerable and encourage more patients to complete their colonoscopy. If successful, this approach could help more people get screened, leading to earlier detection and prevention of colorectal cancer in the community.

Начало: 21.02.2026 Край: 30.12.2026 Възраст: 45–75 г.

United States University of Maryland, Baltimore NCT07320989

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