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Community Health Adaptation & Resilience Mobilization (CHARM) HeatWise

Heat Illness

Extreme heat events pose serious health risks, especially for communities with limited access to cooling, transportation, or social support. This study pilots and tests HEATwise, a heat preparedness program delivered at trusted community centers in Lake County, California, serving older adults, Tribal members, and people experiencing housing or economic hardship. HEATwise is a 12-week program which includes a group workshop on heat risks and preparedness, one-on-one resource navigation, a community celebration event, and a cooling and emergency supply kit. The pilot phase (2026) will assess feasibility and acceptability at three sites with approximately 60 participants. The full trial (2027-2028) will randomly assign eight sites to receive HEATwise immediately or after a delay, measuring whether the program increases protective behaviors, reduces heat-related symptoms, and strengthens resilience over 12 months.

Начало: 15.04.2026 Край: 02.06.2028 Възраст: от 18 г.

United States Public Health Institute, California NCT07500545

Набира участници

Sensory Motor Arousal Regulation Treatment (SMART) Study

PTSD Post-traumatic Stress Disorder

This study will investigate whether a movement and body-based treatment can benefit adults with Post-traumatic Stress Disorder (PTSD). The treatment is called Sensory Motor Arousal Regulation Treatment, or "SMART", and study participation involves 8 sessions of SMART, as well as pre-treatment, post-treatment, and 3-month follow-up assessments.

Начало: 15.04.2026 Край: 15.04.2028 Възраст: 18–65 г.

Canada London Health Sciences Centre Research Institute OR Law NCT06035809

Набира участници Фаза 1/2

Assessing Treatment of T-Cell Lymphoma With GW5282 in Combination With Golidocitinib (BEI-DOU3)

T-cell Lymphomas

This is a phase 1/2 open-label study to evaluate GW5282 in combination with golidocitinib (G2 regimen) for the treatment of T-cell lymphoma. In the first phase of the study, the maximum tolerated dose will be determined through dose escalation; in the second phase, the potential therapeutic advantages of the novel combination therapy over the conventional CHOP regimen will be preliminarily assessed through a randomized controlled design.

Начало: 15.04.2026 Край: 01.12.2029 Възраст: от 18 г.

China Dizal Pharmaceuticals NCT07496229

Набира участници

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

Oral Cavity Cancer

The goal of this clinical trial is to study whether researchers can create a patient-specific tumor system, called a culture vessel, in a timely manner and determine if it can predict how someone will respond to a specific therapy. Participants will: * Undergo a research biopsy * Take pembrolizumab per standard of care prior to surgery

Начало: 15.04.2026 Край: 01.12.2027 Възраст: от 18 г.

United States University of Wisconsin, Madison NCT07343596

Набира участници Фаза 3

Neoadjuvant/Adjuvant AK104 in Microsatellite Instability-high or Mismatch Repair-deficient, Resectable Colon Cancer

Resectable Colon Cancer MSI-H/dMMR Colorectal Cancer

This is a randomized, open-label, controlled, multicenter phase 3 study. All patients are resectable microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) colon cancer. The purpose of this study is to evaluate the efficacy and safety of neoadjuvant/adjuvant treatment of AK104 (Cadonilimab) versus adjuvant chemotherapy in patients with resectable MSI-H/dMMR colon cancer.

Начало: 15.04.2026 Край: 15.03.2031 Възраст: 18–75 г.

China Akeso NCT07412613

Набира участници

Social Media Support Groups for Adolescent Vaping Cessation

Vaping Vaping Cessation Nicotine Dependence

The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program for adolescents and young adults, adapted for use in community settings.

Начало: 15.04.2026 Край: 01.08.2026 Възраст: от 13 г.

United States University of California, San Francisco NCT07540780

Набира участници Фаза 1

A Study to Learn About the Medicine Called PF-08653944 in People With and Without Reduced Liver Function

Healthy

This study is being done to learn more about an investigational medicine called PF-08653944. The goal is to understand how the body handles the medicine and to check its safety after a single dose. The study includes adults with normal liver function and adults who have mild, moderate, or severe liver problems. By comparing these groups, researchers want to understand whether liver function changes how the medicine behaves in the body. People who join the study will receive one injection of the study medicine. They will stay at the study clinic for a short time and return for follow-up visits so doctors can do blood tests, physical exams, and safety checks. This study is not expected to provide direct medical benefit to participants. The information collected will help researchers develop future treatments and understand how this medicine may be used safely in people with liver disease.

Начало: 15.04.2026 Край: 09.07.2027 Възраст: 18–74 г.

United States Pfizer NCT07519135

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THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins

Allergic Inflammatory

Background: Allergic and inflammatory conditions have been increasing over the years. Many factors may play a role in this. Every day, people are exposed to pollution and chemicals in our foods, clothing, and all of the cleaning, hygiene, and other products we use. Studies have suggested there may be links between these environmental exposures and allergic and inflammatory illnesses. Researchers want to know more about how these exposures affect our health. Objective: To learn how everyday exposure to common substances affects people s health. Eligibility: Healthy people aged 18 to 80 years. Design: Participants will have 2 stays in the hospital. Each stay will last 7 days, and the stays will be spaced 4 to 6 weeks apart. During both stays, participants will remain confined to their room. They will eat only food from the menu, and they will use only provided products for personal care. (They may bring their own electronic devices, such as their phone and computer.) One stay will be in a pure room. Participants will breathe filtered air, eat unprocessed foods, and use personal care products with fewer chemicals. One stay will be in a room that allows exposure to common environmental chemicals. Some participants will be limited to only 1 type of exposure: chemicals thought to affect only skin, gut, or respiratory health. Some participants will be exposed to all 3 types. Participants will undergo testing. Blood, skin cell, urine, mouth swabs, and stool samples will be taken. They will have lung tests, smell tests, and tests that measure the health of their skin. These tests will be repeated in outpatient visits 2 weeks after each hospital stay....

Начало: 15.04.2026 Край: 30.01.2031 Възраст: 18–80 г.

United States National Institute of Allergy and Infectious Diseases ( NCT07271381

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Body Clocks - Coordination of Peripheral and Central Oscillators

Circadian Dysregulation

The investigators are conducting an observational trial examining young women over the course of 28 days in which we are monitoring movement, sleep, heart rate, oxygen saturation, gut physiology, light, and menstrual cycle. The inter- and independence of the cyclicity of these variables with each other, the circadian cycle, the menstrual cycle, and the sleep cycle will be tested.

Начало: 15.04.2026 Край: 30.09.2026 Възраст: 18–30 г.

United States Stanford University NCT07459764

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A Study of Cardiac Magnetic Resonance Imaging (CMR) for Evaluating Catheter-Associated Right Atrial Clot in People With Cancer

Adult Cancer Patients Right Atrial Clot

The researchers are doing this study to see how well cardiac magnetic resonance imaging (CMR) scans can be used to examine the properties of central venous catheter-associated right atrial clot (RA clot). This could help doctors decide on the best treatment options.

Начало: 15.04.2026 Край: 01.04.2029 Възраст: от 18 г.

United States Memorial Sloan Kettering Cancer Center NCT07549477

Набира участници Фаза 4

Vonoprazan-based Versus Esomeprazole-based Triple Therapy for Helicobacter Pylori Eradication

Helicobacter Pylori Infection Dyspepsia Peptic Ulcer Disease Helicobacter Pylori +1

The goal of this clinical trial is to compare the efficacy and safety of vonoprazan-based levofloxacin-containing triple therapy with esomeprazole-based levofloxacin-containing triple therapy for eradication of Helicobacter pylori infection in adults with dyspepsia. The main questions it aims to answer are whether vonoprazan-based triple therapy achieves a higher eradication rate of H. pylori, whether it provides greater improvement in dyspeptic symptoms, and what adverse effects are associated with each regimen. Researchers will compare the two treatment regimens to determine which is more effective for H. pylori eradication. Participants with confirmed H. pylori infection will be randomly assigned to receive either vonoprazan-based or esomeprazole-based triple therapy for 14 days. Four weeks after completion of therapy, participants will undergo repeat stool antigen testing to assess eradication. Drug compliance, adverse effects, and dyspeptic symptom scores will be recorded during follow-up. Participants with endoscopic mucosal lesions at baseline will undergo follow-up endoscopy for reassessment.

Начало: 15.04.2026 Край: 14.08.2026 Възраст: от 18 г.

Bangladesh Bangabandhu Sheikh Mujib Medical University, Dhaka, Ban NCT07537634

Набира участници Фаза 2

Epcoritamab, Rituximab, Gemcitabine and Oxaliplatin (R-GemOx) as Salvage Therapy Before Autologous Stem Cell Transplant for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Recurrent High Grade B-Cell Lymphoma, Not Otherwise Specified Recurrent Primary Mediastinal Large B-Cell Lymphoma Recurrent Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma +4

This phase II trial tests how well epcoritamab in combination with rituximab, gemcitabine and oxaliplatin (R-GemOx) works as treatment given after the cancer has not responded to other treatments (salvage therapy) before autologous stem cell transplant in treating patients with diffuse large B-cell lymphoma (DLBCL) that has come back after a period of improvement (relapsed) or that does not respond to treatment (refractory). Epcoritamab is a so-called bispecific antibody, a molecule that can bind simultaneously to two different receptors (proteins present on the cell surface). Epcoritamab binds to a receptor called CD3 with one part of the antibody and to a receptor called CD20 with another part of the antibody. CD3 is expressed on T cells, which are important cells of the immune system that help the body fight cancers and infections. CD20 is expressed on the surface of DLBCL cells. By simultaneous binding to CD3 and CD20, epcoritamab brings T cells and DLBCL cells close together and activates the T cells to kill the lymphoma cells. Rituximab is a so-called monoclonal antibody, a molecule that binds to a single receptor. Like epcoritamab, rituximab binds to CD20. After binding to CD20, rituximab activates the immune system to kill the lymphoma cell through several different mechanisms. Gemcitabine is a chemotherapy drug that blocks the cells from making DNA and may kill cancer cells. Oxaliplatin is in a class of medications called platinum-containing antineoplastic agents. It damages the cell's DNA and may kill cancer cells. Giving epcoritamab-R-GemOx as therapy before an autologous stem cell transplant may help kill cancer cells in the body and help make room in the patient's bone marrow for new blood-forming cells (stem cells) to grow.

Начало: 15.04.2026 Край: 15.10.2029 Възраст: от 18 г.

United States City of Hope Medical Center NCT07365306

Набира участници

Improving Information Sharing Between Family Caregivers and Home Care Aides

Shared Care

This study will assess the feasibility and acceptability of delivering a home care role and preference guide to up to 50 family caregivers and home care aides of persons living with disability for the purpose of identifying roles between family caregivers and home care aides.

Начало: 14.04.2026 Край: 31.08.2027 Възраст: от 18 г.

United States Johns Hopkins Bloomberg School of Public Health NCT07227558

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In-hospital Cardiopulmonary Resuscitation With Balloon Occlusion of the Descending Aorta

Cardiac Arrest

This study will test if a sustained Return of Spontaneous Circulation (ROSC) in patients with cardiac arrest is more frequent when patients receive advanced cardiac life support (ACLS) alone or when they receive ACLS plus a balloon occlusion of the thoracic aorta.

Начало: 14.04.2026 Край: 01.12.2030 Възраст: от 18 г.

Switzerland Insel Gruppe AG, University Hospital Bern NCT07434726

Набира участници

Thrive Person-Centered Planning Program for Young Adults With Fetal Alcohol Spectrum Disorders

Fetal Alcohol Spectrum Disorders

This study evaluates the Thrive person centered planning program for young adults with fetal alcohol spectrum disorders. Participants are randomized to either an immediate start or delayed start group for the psychoeducation phase. Following this phase, participants are randomized again to receive the intervention in either an individual or group based format. Participants complete repeated online assessments at multiple timepoints over approximately 10 months to evaluate whether the program improves goal setting, social support, and quality of life.

Начало: 14.04.2026 Край: 31.08.2028 Възраст: 18–25 г.

United States University of Rochester NCT07016009

Набира участници

Social Prescribing Intervention for Health Promotion in Community-Dwelling Older Adults

Aging Health Promotion Mental Health

This study evaluates the effects of a social prescribing intervention on health promotion outcomes in community-dwelling older adults. The intervention consists of a 4-week mindfulness meditation program followed by a 12-week walking-pole exercise program. The purpose of the study is to determine whether this combined intervention improves physical function, psychological well-being, and sleep quality. Eligible participants aged 55 years and older will be enrolled from community settings and will receive the same 16-week intervention. Assessments will be conducted at baseline, after the mindfulness phase, after completion of the full intervention, and 3 months after the intervention ends. Study outcomes include physical function, mood, well-being, sleep quality, and indicators of continued participation and lifestyle change. The investigators hypothesize that the combined social prescribing intervention will lead to improvements in physical and psychological health among community-dwelling older adults and support healthy aging.

Начало: 14.04.2026 Край: 01.04.2029 Възраст: от 55 г.

Taiwan National Health Research Institutes, Taiwan NCT07540117

Набира участници Фаза 1

A Bioequivalence Study of Two Formulations of HRS-1893 Tablets in Healthy Participants

Cardiomyopathy

This study will investigate the bioequivalence between two formulations of HRS-1893 tablets. Safety and tolerability will also be assessed.

Начало: 14.04.2026 Край: 01.07.2026 Възраст: 18–55 г.

China Shandong Suncadia Medicine Co., Ltd. NCT07479641

Набира участници

Prospective Study of Minimally Invasive (Laparoscopic and Robotic) Hernia Repair (Incisional and Primary, Midline and Lateral, Not Inguinal)

Ventral Hernia Midline Hernia Lumbar Incisional Hernia Repair

We register all adult patients (who have given their informed written consent) who are scheduled for elective repair of an abdominal wall hernia (NOT inguinal hernias) via minimally invasive operation technique (i.e.: laparoscopy or robotic repair) and perform a follow up of 5 years to analyze clinical outcome parameters. These parameters include recurrence of the hernia, intra- and postoperative complications, quality of live, esthetic outcome and pain. The patients will be reviewed in person by the participating physicians at 2-3 moths, 1 year, 3 years and 5 years after surgery. A computed tomography will be performed at 1 year after surgery and in case of suspicion of complications, for example hernia recurrence. The treatment and follow-up of the participating patients does not differ from the standard treatment protocol (and the not participating patients).

Начало: 14.04.2026 Край: 14.04.2036 Възраст: от 18 г.

Spain Instituto de Investigación Sanitaria de la Fundación Ji NCT07544238

Набира участници

Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass

Type 2 Diabetes Obesity Semaglutide GLP-1 +1

The aim of this study is to use advanced MRI scans to track changes in both muscle and fat in the body and heart over a 12-month period in individuals starting semaglutide. By doing so, we hope to gain a clearer understanding of how semaglutide affects muscle health and function. Our goal is to ensure the medication supports long-term well-being, particularly for people who may be at higher risk of muscle loss. This study involves (3) in-person study visits. At each visit, participants will be asked to: * Undergo magnetic resonance imaging (MRI) while resting and during exercise to take pictures of their heart, abdomen, and legs. * Complete tests to assess balance, sit-to-stand, walking speed, and handgrip strength. * Complete questionnaires related to demographics, health information, physical activity, and nutrition. * Have a blood sample collected from a vein in your arm. * Have your blood levels assessed through three finger pricks. * Complete three days of food records.

Начало: 14.04.2026 Край: 30.04.2028 Възраст: 18–80 г.

Canada University of Alberta NCT07272837

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Morphometric Study of the Female Pelvic and Lower Abdominal Retroperitoneum in Cadavers

Pelvic Anatomy Retroperitoneum Cadaveric Study Surgical Anatomy

This study aims to provide a systematic anatomical and morphometric description of the female pelvic and lower abdominal retroperitoneum using cadaveric dissection, with direct application to gynecologic surgery. Standardized dissections will be performed in adult female cadavers obtained from a body donation program. Key anatomical structures, including the ureter, iliac vessels, aorta, inferior vena cava, hypogastric plexuses, and lymphatic territories, will be identified and measured. Spatial relationships, distances, and anatomical variations will be recorded using direct measurements and standardized photographic documentation. The study will quantify anatomical variability and asymmetry between right and left hemipelves, focusing on ureteral, vascular, and neural structures. The results are expected to improve surgical planning, particularly in nerve-sparing techniques and pelvic and para-aortic lymphadenectomy, and to support the development of an applied anatomical atlas for educational and clinical use.

Начало: 14.04.2026 Край: 30.11.2026 Възраст: от 18 г.

Spain Hospital Universitari de Bellvitge NCT07522931

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