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Намерени 4,781 изпитвания Стр. 200 от 240

Active (not recruiting)

Agreement Between ChatGPT-5 and Anesthesiologists in Preoperative Risk Assessment: ASA Classification

Artifical Intelligence Preoperative Evaluation

Accurate preoperative risk stratification is essential for perioperative planning, resource allocation, and patient safety. The American Society of Anesthesiologists Physical Status (ASA-PS) classification remains the most widely used global system for assessing preoperative health status. However, ASA classification relies on clinician judgment and may demonstrate inter-observer variability. Recent advances in artificial intelligence (AI), particularly large language models (LLMs), have shown potential for assisting clinical decision-making by synthesizing structured and unstructured medical information. In perioperative medicine, AI systems may support more standardized risk assessment and laboratory testing strategies. The objective of this observational study is to evaluate the agreement between ASA classifications assigned by anesthesiologists and those generated by a large language model (ChatGPT-5) using anonymized preoperative clinical information. The study will also examine differences in laboratory test recommendations and explore the relationship between clinician- and AI-generated risk assessments and perioperative erythrocyte suspension utilization. Adult patients scheduled for elective surgery who undergo routine preoperative anesthesia assessment will be included. For each patient, the ASA classification assigned by the anesthesiologist will be recorded and compared with the classification generated by the AI system using the same anonymized clinical information. This study aims to assess whether AI-assisted preoperative evaluation may support more consistent risk stratification and potentially contribute to more standardized perioperative resource utilization.

Начало: 10.01.2026 Край: 01.05.2026 Възраст: от 18 г.

Turkey (Türkiye) Damla Kaytancı Özçelik NCT07459491

Active (not recruiting)

New Method for Evaluation of Difficult Intubation in Adults

Difficult Airway Intubation

There are multiple scores used for airway assesment ,the commonest one is LEMON score. LEMON is an airway assessment score that measures factors associated with difficult intubation such as obesity, head and neck movement, jaw movement , receding mandible, long upper incisors, Mallampatti scores, maxillary incisor characteristics, decreased mouth opening ,shorten thyromental distance and short neck. The Height-to-Thyromental Distance ratio (H/TMD) has emerged as a simple, objective, and reproducible anatomical predictor of difficult laryngoscopy, as it normalizes mandibular space to patient height. However, airway difficulty is not purely anatomical; functional factors such as airway obstruction and cervical spine mobility significantly affect intubation success. Therefore, combining H/TMD with two highly predictive functional elements from the LEMON score - Obstruction (O) and Neck Mobility (N) - may provide a more accurate, simplified, and clinically applicable model for predicting difficult airway. This combination is referred to as the HON Model (Height/TMD + Obstruction + Neck mobility).

Начало: 05.01.2026 Край: 15.07.2026 Възраст: 15–60 г.

Egypt Sohag University NCT07461792

Active (not recruiting)

Comparative Evaluation of Ambu AuraGain, LarySeal Pro and I-gel in Pediatric Airway Management for Day-Case Surgery Under Controlled Ventilation

Airway Control

This study aims to compare the Ambu AuraGain, LarySeal Pro LMA, and i-gel regarding their insertion characteristics, ventilation efficacy, risk of gastric insufflation, fiberoptic view quality, intraoperative and postoperative airway-related complications, and hemodynamic stability.165 consecutive pediatric patients aged 2-9 years, weighing 10-30 kg, American Society of Anesthesiologists (ASA) physical status I or II, and scheduled for elective day-case surgery suitable for supraglottic airway device (SGAD) use.Patients will be randomly assigned (n= 55 per group) using a computer-generated random number sequence (www.random.org) to one of three groups: * Group I: Ambu® AuraGain TM (Ambu Ltd Xiang Yu Xiamen, Fujian, China) * Group II: LarySeal Pro® LMA (Flexicare Medical Limited, Cynon Valley Business Park, Mountain Ash, UK).Patients will receive oral midazolam before anesthesia, followed by standard monitoring, induction with sevoflurane, fentanyl, and atracurium, and insertion of an appropriately sized SGAD by experienced anesthesiologists. Ventilation quality, oropharyngeal leak pressure (OLP), peak airway pressure (Ppeak), fiberoptic glottic view, and gastric insufflation by ultrasound will be assessed. Anesthesia will be maintained with controlled ventilation and cuff pressure adjusted to 60 cmH₂O. At the end, neuromuscular blockade will be reversed, devices removed upon awakening, and patients observed for complications such as laryngospasm, Outcome parameter (s): * Oropharyngeal Leak Pressure (OLP). * Demographic and Clinical Data. * Hemodynamics. * Insertion Data. * Peak Airway Pressure (Ppeak). * Fiberoptic Glottic View Assessment. * Ultrasound Assessment of Gastric Insufflation. * Perioperative Complications.bronchospasm, or sore throat. * Group III: I-gelTM (Intersurgical Ltd, Berkshire, RG41 2RZ, UK).

Начало: 01.01.2026 Край: 15.07.2026 Възраст: 2–9 г.

Egypt Kasr El Aini Hospital NCT07274280

Active (not recruiting)

Optimization and Standardization of Single-Port Robotic Transanal Minimally Invasive Surgery for Rectal Tumor Excision

Rectal Neoplasms Rectal Cancer Patients Rectal Benign Lesions

Title Case Summary: "This study evaluates the safety, feasibility, and short-term clinical outcomes of a new surgical approach called Single-Port (SP) Robotic Transanal Minimally Invasive Surgery (SPR TAMIS) for treating rectal tumors." Content: Transanal Minimally Invasive Surgery (TAMIS) is a standard technique for treating early-stage rectal tumors. However, traditional TAMIS often faces challenges such as restricted vision and instrument crowding in the narrow rectum. The purpose of this study is to establish a standardized surgical procedure using a single-port robotic platform, which provides better flexibility and visualization. The investigators will analyze real-world clinical cases and surgical videos to assess key outcomes, including the success of tumor resection (R0 resection rate), operative safety, and patient recovery parameters. The study aims to provide clinical evidence for this robotic technique and facilitate its standardized implementation in surgical practice.

Начало: 01.01.2026 Край: 31.12.2029 Възраст: 20–80 г.

Taiwan Jeng-Fu You NCT07522294

Active (not recruiting)

Construction and Validation of an Intelligent Ultrasound Diagnostic System for the Spectrum of Neuroblastoma in Children

Neuroblastic Tumors

The goal of this observational study is to build an intelligent ultrasound diagnostic system that integrates pathological typing, risk stratification and prognosis assessment. The main question it aims to answer is: 1. Can the prediction model of neuroblastoma tumors (NTs) in children based on ultrasound images distinguish each pathological subtype? 2. Can the multimodal fusion model established based on clinical and pathological features identify high-risk patients, predict bone marrow metastasis, and estimate the therapeutic effect? 3. Can this ultrasound diagnostic system achieve a systematic and intelligent assessment of NTs patients to assist in clinical risk stratification and individualized treatment decisions?

Начало: 01.01.2026 Край: 30.09.2026 Възраст: до 18 г.

China The Children's Hospital of Zhejiang University School o NCT07549425

Active (not recruiting)

Augmentation of Peri-implant Keratinized Mucosa Using a Combination of Free Gingival Graft Strip With Platelet-Rich Fibrin

Dental Implants

This clinical trial aims to evaluate the clinical effectiveness of combining a strip free gingival graft (sFGG) with Platelet-Rich Fibrin (PRF) for increasing keratinized mucosa around dental implants. The study compares this combined technique with the conventional free gingival graft (FGG) method through three primary objectives: 1. comparing the increase in keratinized mucosal height at immediate post-op, 1, 3, and 6 months; 2. assessing post-operative pain levels at 1, 3, 7, and 14 days; 3. evaluating soft tissue aesthetic outcomes at 4 and 6 months post-surgery.

Начало: 24.12.2025 Край: 01.07.2026

Vietnam Nguyen Van Khuong NCT07346391

Active (not recruiting) Phase 3

A Study to Assess the Efficacy and Safety of Zipalertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB-IIIA NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection

NSCLC, Stage IB-IIIA Lung Cancer Adjuvant Post-surgical +4

The purpose of this study is to compare the efficacy of zipalertinib combined with adjuvant chemotherapy versus placebo combined with adjuvant chemotherapy in participants with early stage (stage IB-IIIA) resected non-small cell lung cancer (NSCLC) harboring uncommon epidermal growth factor receptor mutation (EGFRmt).

Начало: 22.12.2025 Край: 01.10.2032 Възраст: от 18 г. Treatment

Argentina, Australia, Belgium +21 Taiho Oncology, Inc. NCT07128199

Active (not recruiting)

Radicle Relief RAL™: A Study Assessing the Impact of Health and Wellness Products on Pain Relief and Related Health Outcomes

Pain Interference

Radicle Relief RAL: A randomized, double-blind, placebo-controlled study assessing the impact of health and wellness products on pain relief and related health outcomes.

Начало: 18.12.2025 Край: 04.01.2027 Възраст: 21–105 г.

United States Radicle Science NCT07262775

Active (not recruiting)

Low Dose Radiotherapy in Primary Indolent Cutaneous B-cell Lymphoma

Primary Indolent Cutaneous B-cell Lymphoma

Primary indolent cutaneous B cell lymphomas (PCBCL) are rare: although data on outcomes and treatment are limited, traditionally they have been treated with radiation doses in excess of 24 Gy. Recently, some trials that patients with primary cutaneous indolent lymphoma managed with very low dose (4 Gy) RT (LDRT) have shown that high response rates and durable remission can be achieved; unfortunately, given the retrospective nature of these studies, the role of LDRT in indolent PMCL remains undefined. The objective of this retrospective multicentric trial is to investigate the efficacy of low-dose involved-field radiation therapy in patients with primary indolent cutaneous B-cell Lymphoma.

Начало: 18.12.2025 Край: 01.12.2026 Възраст: от 18 г.

Italy Azienda USL Reggio Emilia - IRCCS NCT07310745

Active (not recruiting) Phase 1/2

A Study of REGN7041 for Active Noninfectious Uveitis in Adult Participants

Active Noninfectious Uveitis Affecting the Posterior Segment

This study is researching an experimental drug called REGN7041 (also referred to as "study drug"). The study is focused on patients who have active inflammation inside of the eye without any signs of infection. The aim of the study is to see how safe and tolerable the study drug is. This is the first time the study drug is being tested in humans. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood and the fluid in the eye at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)

Начало: 17.12.2025 Край: 28.06.2028 Възраст: от 18 г.

United States Regeneron Pharmaceuticals NCT07218770

Active (not recruiting)

Radicle GI Health RDH™: A Study Assessing the Impact of Health and Wellness Products on Gastrointestinal (GI) Health and Related Health Outcomes

Gas and Bloating Diarrhea Constipation

A Randomized, Double-Blind, Placebo-Controlled Direct-to-Consumer Study Assessing the Impact of Health and Wellness Products on Gastrointestinal (GI) Health and Related Health Outcomes

Начало: 16.12.2025 Край: 11.12.2026 Възраст: 21–105 г.

United States Radicle Science NCT07230821

Active (not recruiting)

Central Sensitisation in Nociceptive and Neuropathic Pain

Chronic Pain Nociceptive Pain Neuropathic Pain Mixed Pain (Nociceptive and Neuropathic)

This study aims to investigate differences in central sensitization among patients with chronic nociceptive pain, neuropathic pain, and mixed pain conditions. Chronic pain is a complex and multidimensional phenomenon involving sensory, cognitive, emotional, and behavioral components, often sustained by mechanisms of central sensitization that contribute to pain persistence and treatment resistance. Using a multidimensional assessment approach, the study integrates self-report questionnaires, neuropsychological evaluation, psychological measures, treatment adherence assessment, and neurophysiological investigation through laser-evoked potentials (LEP). Participants will be evaluated at baseline and after 12 months to explore differences between pain types and longitudinal changes in central sensitization, cognitive functioning, emotional status, and engagement with treatment. The findings are expected to improve the understanding of neurobiological and psychosocial mechanisms underlying different chronic pain phenotypes and to support more personalized and effective pain management strategies.

Начало: 15.12.2025 Край: 20.12.2027 Възраст: 18–90 г.

Italy IRCCS Centro Neurolesi Bonino Pulejo NCT07321080

Active (not recruiting)

Effectiveness of Dexamethasone Injection for Reducing Pain After Third Molar Surgery

Impacted Mandibular Third Molar Postoperative Pain

This randomized clinical trial aims to evaluate the effectiveness of dexamethasone injection in reducing postoperative pain after surgical removal of impacted mandibular third molars. Patients are divided into two groups: one receiving standard local anesthesia, and the other receiving an additional dexamethasone injection postoperatively. Pain levels are assessed using the Visual Analogue Scale (VAS) at 24, 48, and 72 hours after surgery. The study is conducted at 28 Military Dental Centre, Lahore.

Начало: 01.12.2025 Край: 30.05.2026 Възраст: 20–40 г.

Pakistan 28 Military Dental Centre Lahore NCT07538375

Active (not recruiting) Phase 2

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma

Melanoma (Skin Cancer) Unresectable Melanoma Metastatic Melanoma

This is a Phase 2, multicenter, open-label study of lifileucel (tumor-infiltrating lymphocytes \[TIL\]) in participants with previously treated advanced melanoma

Начало: 28.11.2025 Край: 01.12.2033 Възраст: 18–70 г. Treatment

Australia, Canada, United Kingdom +1 Iovance Biotherapeutics, Inc. NCT07288203

Active (not recruiting) Phase 3

A Study to Learn About Different Dosing Schedules of a Lyme Disease Vaccine in Healthy Adults

Lyme Borreliosis

The purpose of this study is to learn about the safety and effects of the Lyme disease vaccine (called VLA15) when given at different time points. This study is seeking participants who: * are generally healthy and between 18 and 44 years of age, * have never had a vaccine for Lyme disease before, * are not currently taking, or haven't recently taken, medicines like chemotherapy, blood products, or blood thinners, and * are not pregnant or breastfeeding and do not plan to become pregnant while receiving the study vaccine. All participants in this study will receive a total of 5 doses through a shot in the upper arm. Four doses will be the study vaccine (VLA15), and 1 dose will be saltwater. The study will compare the experiences of people receiving the study vaccine at different time points. This will help see if the study vaccine is safe and will help understand its effect on the body. Participants will take part in this study for about 2 years. During this time, the participants will have 11 planned visits - 8 will be at the study clinic and 3 will be done over the phone. The clinic visits may include having a health check, giving a small amount of blood (about 20 mL or 4 teaspoons), and getting the study vaccine or saltwater as a shot.

Начало: 19.11.2025 Край: 27.01.2028 Възраст: 18–44 г.

United States Pfizer NCT07226882

Active (not recruiting) Phase 3

A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight

Obesity Overweight

The purpose of this study is to evaluate the efficacy and safety of retatrutide compared with placebo for body weight reduction. Participation in the study will last about 65 weeks and may include about 18 visits.

Начало: 17.11.2025 Край: 01.07.2027 Възраст: от 18 г.

United Kingdom, United States Eli Lilly and Company NCT07232719

Active (not recruiting)

Vital Pulp Therapy Versus Root Canal Treatment for Irreversible Pulpitis With Incipient Apical Periodontitis Diagnosed Using Artificial Intelligence This Keeps: the Main Intervention (Vital Pulp Therapy) the Comparison (Root Canal Treatment) the Condition (Irreversible Pulpitis With Incipient Apic

Symptomatic Irreversible Pulpitis

This study evaluates postoperative pain and treatment outcomes following vital pulp therapy and root canal treatment in patients with symptomatic teeth. Participants will receive either vital pulp therapy or standard root canal treatment, and pain will be measured using standardized pain scores at different time intervals after treatment. The primary outcome is postoperative pain intensity in the early healing period. Secondary outcomes include long-term clinical and radiographic success at 6 months and 1 year. Radiographic outcomes will be assessed using artificial intelligence (AI)-assisted analysis to improve evaluation of healing and treatment success. The study aims to compare pain progression and long-term outcomes between the two treatment approaches.

Начало: 15.11.2025 Край: 08.04.2027 Възраст: 18–40 г.

Egypt Ain Shams University NCT07549620

Active (not recruiting) Phase 3

Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide

Overweight Obesity Type 2 Diabetes

This study will look at how much cagrilintide helps people with overweight or obesity and type 2 diabetes lower their body weight. Cagrilintide is a new investigational medicine. Doctors may not yet prescribe cagrilintide. Participant will either get cagrilintide or placebo. Which treatment participant get is decided by chance. Participants are two times more likely to get cagrilintide than placebo. Like all medicines, the study medicine may have side effects. For each participant, the study will last for about 1 year and 6 months.

Начало: 05.11.2025 Край: 30.06.2027 Възраст: от 18 г.

Argentina, Canada, Croatia +8 Novo Nordisk A/S NCT07220759

Active (not recruiting)

Autogenous Soft Tissue Grafts for Primary Closure Over Immediately Placed Dental Implants

Soft Tissue Augmentation at Dental Implants Marginal Bone Loss

The aim of this interventional study is to evaluate the best method to place the autogenous soft tissue grafts for primary closure over immediately-placed dental implants. \- Primary hypothesis, there is no differences between the two techniques of placement.

Начало: 01.11.2025 Край: 01.05.2026 Възраст: 18–45 г.

Egypt Mansoura University NCT07327047

Active (not recruiting)

The Effect of a Patient Education Program on Vitamin D Levels and Health Beliefs Regarding Vitamin D Use

Those Who Provided Written Informed Consent Female Gender Aged 18 Years and Older Hypothyroidism Disease +1

Background and Rationale: Vitamin D deficiency is a major public health concern. While clinical guidelines provide treatment protocols, medication adherence remains a significant barrier to achieving target serum levels. This study aims to evaluate whether a structured patient education program can improve health beliefs and adherence, ultimately leading to better clinical outcomes. Study Procedures: Participants identified with Vitamin D levels \

Начало: 01.11.2025 Край: 01.06.2026 Възраст: от 18 г.

Turkey (Türkiye) Karadeniz Technical University NCT07535671

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