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Намерени 4,781 изпитвания Стр. 205 от 240

Активно (без набиране)

Inferior Calcaneal Nerve Radiofrequency Ablation for Chronic Heel Pain

Plantar Fasciitis, Chronic Calcaneal Spur Chronic Heel Pain

This prospective single-arm pilot interventional study aims to evaluate the effectiveness of ultrasound-guided radiofrequency ablation of the inferior calcaneal nerve in patients with chronic heel pain refractory to conservative treatments. Patients with plantar fasciitis or calcaneal spur who have not responded to multiple treatment modalities, including exercise, nonsteroidal anti-inflammatory drugs, orthotics, extracorporeal shockwave therapy, and corticosteroid injections, will be included. The procedure will be performed under ultrasound guidance. Pain intensity, functional status, and patient satisfaction will be assessed at baseline and at 1 and 3 months after the intervention. The primary outcome is treatment success, defined as a ≥50% reduction in pain intensity at 1 month compared to baseline.

Начало: 31.03.2025 Край: 30.06.2026 Възраст: 18–75 г.

Turkey (Türkiye) Şahide Eda Artuç NCT07537907

Активно (без набиране) Фаза 1/2

Platform Trial Evaluating Treatment of Neoadjuvant Trastuzumab-deruxtecan Containing Combination Therapies for HER2+, Resectable Esophagogastric Adenocarcinoma

Esophagogastric Adenocarcinoma

The study is a phase Ib/II, prospective, single arm, open label, non-randomized, multi-center platform trial assessing the feasibility and safety of different neoadjuvant trastuzumab-deruxtecan containing combinational treatment regimens in patients with HER2 positive, locally advanced, resectable esophagogastric adenocarcinoma

Начало: 25.03.2025 Край: 31.12.2027 Възраст: от 18 г.

Austria, Germany Institut für Klinische Krebsforschung IKF GmbH at Krank NCT06731803

Активно (без набиране) Фаза 2

A Phase 2a Multicenter Clinical Trial of TB006 in Participants With Parkinson's Disease

Parkinson's Disease (PD)

The primary objectives of this study are to assess the efficacy of TB006 in improving motor function and to assess the safety of TB006 in participants with Parkinson's Disease (PD).

Начало: 20.03.2025 Край: 28.11.2026 Възраст: 50–80 г.

United States TrueBinding, Inc. NCT06773962

Активно (без набиране) Фаза 2

A Study of LY3541860 in Adult Participants With Moderately to Severely Active Rheumatoid Arthritis

Rheumatoid Arthritis

The main purpose of this study is to evaluate the effects of LY3541860 in adult participants with moderately to severely active Rheumatoid Arthritis with inadequate response to a least one biologic disease-modifying antirheumatic drug (bDMARD)or targeted synthetic disease-modifying antirheumatic drug (tsDMARD). Study participation is approximately 50 weeks, including a 6-week screening period, 24-week treatment period, and a 20-week safety follow up period.

Начало: 19.03.2025 Край: 01.05.2026 Възраст: 18–75 г.

United States Eli Lilly and Company NCT06859294

Активно (без набиране)

Observational Study to Evaluate the Efficacy of Sustained QUTENZA® Use in Painful Diabetic Peripheral Neuropathy

Peripheral Diabetic Neuropathy Painful Diabetic Neuropathy

The purpose of this post-market observational study is to provide real-world evidence to support the repeated use of QUTENZA in patients with PDPN and to evaluate the potential for pain and concomitant medication use reduction.

Начало: 14.03.2025 Край: 01.03.2027 Възраст: 18–80 г.

United States Averitas Pharma, Inc. NCT06495424

Активно (без набиране) Фаза 3

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of a New Maintenance Dosing Regimen of Ofatumumab

Relapsing Multiple Sclerosis (RMS)

This study will evaluate the pharmacokinetics, pharmacodynamics, safety and tolerability of a new dosage of ofatumumab compared to the approved dosage of ofatumumab followed by extended treatment in participants with relapsing multiple sclerosis.

Начало: 13.03.2025 Край: 23.03.2030 Възраст: 18–100 г.

Puerto Rico, United States Novartis Pharmaceuticals NCT06869785

Активно (без набиране) Фаза 4

Magnesium as an Adjuvant Agent for Postoperative Pain

Pain, Postoperative

Participants are being asked to participate in this research study because they have elected to undergo periacetabular osteotomy (PAO). This research study is looking at if using IV magnesium during surgery can help to reduce pain after surgery.

Начало: 10.03.2025 Край: 31.08.2026 Възраст: 14–89 г.

United States University Hospitals Cleveland Medical Center NCT05947760

Активно (без набиране) Фаза 1

Study of 225Ac-ABD147 to Establish Optimal Dose in Patients With SCLC and LCNEC of the Lung That Previously Received Platinum-based Chemotherapy

Small-Cell Lung Cancer (SCLC) Large Cell Neuroendocrine Carcinoma of the Lung

The study has 2 parts, Phase 1a and Phase 1b. The goal of Phase 1a is to gather safety, PK and initial efficacy data for 225Ac-ABD147 to better understand best doses for patients with small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC) of the lung following platinum-based chemotherapy. An initial group of patients will also be given an experimental imaging agent called 111In-ABD147 to help understand where ABD147 goes in the body. The goal of Phase 1b is to gather additional safety and efficacy data on 225Ac-ABD147 to determine the best dose and to understand how those doses affect the same types of patients' cancers explored enrolled in Phase 1a.

Начало: 10.03.2025 Край: 01.01.2027 Възраст: от 18 г.

United States Abdera Therapeutics Inc. NCT06736418

Активно (без набиране) Фаза 1/2

A Chatbot To Support Substance Use Recovery

Opiate-Related Disorders Opiate Substitution Treatment

The goal of this clinical trial is to learn if/how an AI chatbot can support patients who in recovery for substance use, specifically those who are receiving medication for opioid use disorder. Can the chatbot help lower drug use? Can the chatbot help improve clinical appointment adherence? Can the chatbot help patients build self-efficacy in leading their own recovery journey? Will the chatbot help reduce workload burden for primary care teams? Can the chatbot serve as a safe, useful and engaging tool to support patients? Researchers will investigate the effects of using a chatbot to support follow-up care for patients in opioid use recovery. Participants will: * Receive access to a chatbot for 12 weeks that they can use to prepare for upcoming clinical appointments, find community resources, learn about urge-surfing and wellness techniques, and query for assistance with other recovery-related information and tasks * Complete surveys and provide user feedback

Начало: 07.03.2025 Край: 31.08.2026 Възраст: 18–65 г.

United States Dimagi Inc. NCT06845878

Активно (без набиране)

Keraring Implantation Based on Alfonso Nomogram

Keratoconic Subjects

Keratoconus (KC) is a bilateral asymmetric progressive corneal degenerative disease associated with corneal thinning and protrusion. The management of moderate progressive keratoconus involves halting its progression through corneal cross-linking as well as flattening of the ectatic steep cornea through the implantation of intrastromal corneal rings (ICR). Different nomograms were used to guide ophthalmic surgeons for the proper choice of ICR implantation to achieve the best results. The aim of the current study is to assess the visual, refractive and tomographic outcomes of Keraring implantation based on the Alfonso nomogram, in patients with keratoconus.

Начало: 01.03.2025 Край: 01.09.2026 Възраст: 18–35 г.

Egypt Assiut University NCT07540208

Активно (без набиране) Фаза 1/2

NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia

Infertility, Male

This clinical interventional study aims to assess whether treatment with denosumab in combination with letrozole can improve sperm production in infertile men with non-obstructive azoospermia selected by serum anti-mullerian hormone (AMH) as a positive predictive biomarker.

Начало: 01.03.2025 Край: 01.08.2026 Възраст: 18–60 г.

Denmark Martin Blomberg Jensen NCT06706414

Активно (без набиране)

Empowering Newcomer Voices: A Trauma-Informed, Gender-Responsive Group Intervention in Schools (VOCES-NUEVAS)

Mental Health

The goal of this study is to see if VOCES-NUEVAS, a school-based program for newcomer girls from Latin America, is helpful and easy to use. The main questions the investigators want to answer are: * Is VOCES-NUEVAS a good fit for newcomer girls in schools? * Does it help improve their mental health and well-being? Students who are already part of the VOCES-NUEVAS program at four school-based health centers will take short surveys before and after the program and give feedback after each session. The adults leading the program will also share their thoughts in group discussions or interviews. The results will help improve the program and prepare for a larger study in the future.

Начало: 01.03.2025 Край: 01.12.2026 Възраст: от 12 г.

United States University of California, San Francisco NCT07041931

Активно (без набиране) Фаза 2

A Phase 2 in Adult Subjects With Hereditary Angioedema

Hereditary Angioedema (HAE)

A Phase 2 in Adult Subjects with Hereditary Angioedema

Начало: 28.02.2025 Край: 30.03.2028 Възраст: 18–70 г.

China, Germany, Italy +3 Shanghai Argo Biopharmaceutical Co., Ltd. NCT06846398

Активно (без набиране) Фаза 1

Safety and Immunogenicity of an Inactivated West Nile Virus Vaccine in Healthy Adults

West Nile Viral Infection

A randomized, placebo controlled, double-blind (within dosing group), sequential dose escalation study. This phase 1 trial addresses the urgent need for a vaccine to prevent disease resulting from infection with West Nile virus (WNV), a virus that is primarily spread to people by the bite of an infected mosquito. The purpose of this Phase 1 trial is to evaluate the safety and immunogenicity of the HydroVax-001B WNV vaccine in healthy adult volunteers. The study Population will consist of healthy male and non-pregnant, non-breastfeeding female adults, 18 to 49 years of age, inclusive. Potential participants with a history of prior flavivirus infection or receipt of any flavivirus vaccine or monoclonal antibody, and those who likely had a prior flavivirus infection based on exposure history will be ineligible for the study. Participants will be randomized to receive HydroVax-001B WNV vaccine or placebo in a 12:3 ratio within a dosage group. Participants will be sequentially enrolled into two dosage groups. The primary objective is to assess the safety and reactogenicity of 4 mcg versus 10 mcg dose of the HydroVax-001B WNV vaccine administered intramuscularly (IM) on Days 1, 29 and 181.

Начало: 24.02.2025 Край: 01.11.2027 Възраст: 18–49 г.

United States National Institute of Allergy and Infectious Diseases ( NCT06745921

Активно (без набиране)

Comparison of Perforated 3D Printed Versus Conventional Metal Fixed Bonded Retainer

Bond, Pair

Although different materials of mandibular fixed retainer were discussed in the literature, there is contradicting evidence regarding the bond failure of Titanium fixed metal retainer, whether immediate or after 12 months. Moreover, insufficient evidence is present regarding 3D metal printed fixed mandibular retainers.

Начало: 14.02.2025 Край: 01.06.2026 Възраст: 15–35 г.

Egypt Mariam Alaa NCT06851897

Активно (без набиране) Ранна Фаза 1

Fecal Microbiota Transplant for Autobrewery Syndrome

Auto-Brewery Syndrome Gut Fermentation Syndrome

The goal of this clinical trial is to study fecal microbiota transplantation(FMT) by oral capsule in people already diagnosed with auto-brewery syndrome (ABS, also known as gut fermentation syndrome). The main question it aims to answer: Is FMT safe and feasible in this syndrome? Participants will 1. have a "gut cleanout" with oral antibiotics and a colon cleanse, similar to that administered before colonoscopy 2. receive five oral doses of fecal transplant capsules over a week 3. be followed for six months for safety and research samples

Начало: 14.02.2025 Край: 31.08.2030 Възраст: 18–70 г.

United States Massachusetts General Hospital NCT06083142

Активно (без набиране)

Aviclear for Hidradenitis Suppurativa (HS)

Hidradenitis Suppurativa

The objective is to evaluate the safety and efficacy of the Cutera 1726 nm laser system (also referred to as AviClear) for the treatment of HS.

Начало: 12.02.2025 Край: 01.08.2026 Възраст: 18–60 г.

United States University of Miami NCT06801795

Активно (без набиране) Фаза 1/2

Effectiveness of MMS Compared With IFS Among Pregnant Women in Bangladesh: an Experimental Study

Pregnant Women Pregnant Women and Their Offspring

Background Maternal undernutrition and micronutrient deficiencies remain highly prevalent in Bangladesh and contribute to maternal anaemia, low birth weight, preterm birth, and adverse neonatal outcomes. Although iron-folic acid supplementation (IFAS) is routinely provided through antenatal care services, it does not address the full spectrum of micronutrient deficiencies. Multiple micronutrient supplementation (MMS) has demonstrated superior outcomes in clinical trials; however, evidence from real-world programmatic settings in Bangladesh is limited. Methods and analysis This experimental study will be conducted from March 2025 to March 2026 through antenatal care platforms coordinated by the Institute of Public Health Nutrition (IPHN), with centralised laboratory analysis at the National Institute of Neurosciences \& Hospital (NINS\&H), Dhaka. Pregnant women will receive either MMS or IFAS according to routine service delivery. The primary outcome is infant birth weight. Secondary outcomes include maternal haemoglobin and micronutrient biomarkers, preterm birth, dietary diversity, and supplementation adherence. Quantitative data will be analysed using multivariable regression models in SPSS with adjustments for confounders and geographic clustering. A concurrent process evaluation will assess implementation, fidelity and acceptability. Ethics and dissemination Ethical approval has been obtained from the Institutional Review Board of NINS\&H. Written informed consent will be obtained from all participants. Study findings will be disseminated through peer-reviewed publications, policy briefs, and stakeholder engagement workshops.

Начало: 11.02.2025 Край: 31.05.2026 Възраст: 15–35 г.

Bangladesh National Institute of Neurosciences and Hospital, Dhaka NCT07540130

Активно (без набиране) Фаза 1

Slow Introduction of Nutrition for Ill Malnourished Children

Malnutrition, Severe Acute Malnutrition, Child Malnutrition, Infant

The goal of this clinical trial is to learn if giving lower calorie feeds during the first stage of treatment helps improve survival in severely malnourished children who are ill. The main question it aims to answer is: Is it safe to feed ill severely malnourished children lower calorie feeds during the early treatment phase? Researchers will compare two lower calorie feeds (F50 and F35) to the standard feed (F75) to see if they help children recover safely without increasing their risk of low blood sugar (hypoglycemia). Participants will: * Receive one of the lower calorie feeds (F50 or F35) or the standard feed (F75) during their hospital stay. * Be closely monitored for low blood sugar and signs for worsening of clinical symptoms. * Be treated until they are stable and ready to be fed more calories to help them gain weight.

Начало: 05.02.2025 Край: 01.06.2026 Възраст: 6–59 г.

Bangladesh, Malawi The Hospital for Sick Children NCT06846749

Активно (без набиране)

Knowledge Levels and Experiences of Intensive Care Nurses on the Prevention of Pressure Sores: Mixed Method

Nurses Pressure Ulcer Critical Care

This research aims to determine the knowledge levels and practices of intensive care nurses regarding the prevention of pressure sores. The main questions it aims to answer are: 1. What is the level of knowledge of intensive care nurses regarding the prevention of pressure sores? 2. What is the impact of sociodemographic characteristics of intensive care nurses on their knowledge level regarding the prevention of pressure sores? 3. What are the experiences of intensive care nurses regarding their practices for the prevention of pressure sores? In this research, a survey and interview technique will be applied to determine the knowledge levels and experiences of nurses working in adult intensive care units regarding the prevention of pressure sores and their practices.

Начало: 04.02.2025 Край: 18.04.2026

Turkey (Türkiye) Burdur Mehmet Akif Ersoy University NCT06457555

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