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Набира участници

Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac Surgery

Microcirculatory Diffusion Microcirculatory Convection Capacity Venous Congestion Postoperative Cardiac Surgery +2

The aim of the VeMic study is to explore if venous congestion is linked with microcirculatory impairment in elective cardiac surgery patients in the postoperative ICU stay.

Начало: 14.04.2026 Край: 30.09.2027 Възраст: от 18 г.

Switzerland University Hospital, Basel, Switzerland NCT07052461

Набира участници

A Study of Uveitis in Children

Uveitis

The goal of this observational study is to collect data regarding clinical features and current/past treatments in children under 18 with uveitis. The main questions it aims to answer are: * What are the frequency of uveitis subtypes in children? * What are clinical and demographic characteristics overall and within each type of uveitis? Participants will complete one enrollment visit with their doctor. Participants with uveitis onset \

Начало: 14.04.2026 Край: 01.04.2028 Възраст: до 17 г.

United States Jaeb Center for Health Research NCT07518134

Набира участници

Investigation of REcurrence Mechanisms to Adjuvant osimertINib in Radically Resected EGFR-mutated NSCLC Patients

EGFR-mutated NSCLC

Retrospective-prospective observational multicentric study including radically resected EGFR-mutated NSCLC patients relapsed during or after adjuvant osimertinib, received according to clinical practice

Начало: 14.04.2026 Край: 01.12.2028 Възраст: от 18 г.

Italy Gruppo Oncologico Italiano di Ricerca Clinica NCT07363252

Набира участници

Survey on Physical Activity and Qualify of Life in Fibromuscular Dysplasia

Fibromuscular Dysplasia of Arteries Fibromuscular Dysplasia Spontaneous Coronary Artery Dissection

Fibromuscular dysplasia (FMD) is a disease of the arteries that is not due to plaque build-up or inflammation. While some patients with FMD are health, some may experience heart attacks, strokes, aneurysms or blood vessel dissection/tearing which can be life-threatening. It predominantly impacts women and younger patients. As a result of this diagnosis, many patients are counseled to restrict or avoid certain physical activities out of concern for provoking or worsening vascular complications. There are no guidelines or consensus recommendations regarding appropriate physical activity for patients with FMD. The lack of consensus may lead to confusion for patients and may negatively impact their quality of life. This study will conduct a large, national survey of patients with FMD to assess the type of physical activity restrictions and impact on quality of life and emotional well-being.

Начало: 14.04.2026 Край: 30.06.2027 Възраст: 18–100 г.

United States Vanderbilt University Medical Center NCT07529691

Набира участници

Effectiveness of a Visual Biofeedback Program Versus Conventional Physiotherapy on Shoulder Mobility, Strength, and Function in Women After Breast Cancer Surgery

Breast Cancer Shoulder Dysfunction

This study aims to evaluate the effectiveness of a physiotherapy program incorporating visual biofeedback compared to a conventional physiotherapy program in improving shoulder function in women following breast cancer surgery. Breast cancer survivors frequently experience shoulder dysfunction, including reduced range of motion, decreased strength, altered neuromuscular activity, and impaired scapulohumeral control. While conventional physiotherapy is effective, there is growing interest in interventions targeting motor control and neuromuscular coordination through biofeedback strategies. Participants will be randomly assigned to either a control group receiving conventional physiotherapy or an experimental group receiving the same program supplemented with visual biofeedback using the MotionGuidance system. Outcomes will include shoulder strength, range of motion, functional performance, electromyographic activity, and muscle oxygen saturation.

Начало: 14.04.2026 Край: 15.05.2026 Възраст: от 18 г.

Spain University of Extremadura NCT07542106

Набира участници Фаза 2

A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With Asthma

Asthma

The purpose of this study is to evaluate the effect of 2 different GP metered dose inhaler (MDI) doses relative to placebo MDI as add-on treatment to BFF MDI on lung function in participants 4 to less than 12 years of age with asthma.

Начало: 14.04.2026 Край: 23.05.2029 Възраст: 4–11 г.

Argentina, Czechia, Hungary +4 AstraZeneca NCT07525375

Набира участници

Effects of Nunchaku Exercise for Improving Frozen Shoulder

Adhesive Capsulitis

The goal of this clinical trial is to investigate if nunchaku exercise works to treat adhesive capsulitis, or frozen shoulder in middle-aged or older adults. It will also learn about the adherence of this exercise intervention. The main questions it aims to answer are: * Does practicing nunchaku exercises help reduce shoulder pain and improve shoulder movement? * Do people stick with nunchaku exercises better, and spend more time practicing on their own, compared with standard exercises for alleviating frozen-shoulder? Researchers will compare nunchaku exercise to standard exercises for alleviating frozen-shoulder to see if nunchaku exercise works to alleviate frozen shoulder. Participants will: * Join small group exercise classes for 12 weeks, doing either nunchaku based exercises or standard exercises designed to help relieve frozen shoulder. * Have their shoulder pain and movement checked three times: * before training * after 6 weeks of training, * after finishing the 12 week program, and * 12 weeks after the program ends. * Keep a record of their home practice time.

Начало: 14.04.2026 Край: 31.12.2026 Възраст: от 45 г.

Hong Kong Chinese University of Hong Kong NCT07486193

Набира участници Фаза 2

A Study of Hydronidone Capsules in Patients With Chronic Hepatitis B Virus-Related Liver Fibrosis

Chronic Hepatitis B-related Liver Fibrosis

This trial employs a single-arm, open-label, multicenter clinical trial design. All study participants who meet the inclusion/exclusion criteria will receive Hydronidone treatment for 4 weeks. The study includes a screening period (up to 21 days) to assess the eligibility of participants. Eligible participants will enter the treatment period and receive Hydronidone capsules at a dosage of 270 mg TID (30 mg/capsule, 3 capsules each time, three times daily, taken orally half an hour before meals) for 28 consecutive days. Participants will return for a follow-up visit on Day 28 (±3 days) after the first dose for safety assessments. All adverse events (AEs) and concomitant medications occurring during the study period must be recorded. After the treatment period, participants will enter a follow-up period to monitor any delayed adverse events. Participants who complete the final follow-up visit are considered to have completed the study. Throughout the study, participants must maintain the stability of all their pre-existing treatment regimens, including antiviral therapy and medications for other comorbid conditions.

Начало: 14.04.2026 Край: 30.07.2026 Възраст: 18–70 г.

China Beijing Continent Pharmaceutical Co, Ltd. NCT07417553

Набира участници Фаза 4

Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery

Laparoscopic Surgery Visceral Pain, Postoperative Anrikefon Patient-controlled Intravenous Analgesia

Visceral pain following laparoscopic surgery is frequently underestimated, yet it is associated with a range of adverse outcomes. Effective visceral pain management should constitute an essential component of postoperative analgesic strategies following laparoscopic procedures. However, conventional analgesic agents, including μ-opioid receptor agonists, lack specificity for visceral pain. Anrikefon, a novel selective peripheral κ-opioid receptor agonist, demonstrates unique efficacy in alleviating visceral pain with a favorable safety profile. Preliminary studies showed that a single intravenous dose of anrikefon effectively alleviates postoperative pain after abdominal surgery with a low risk of adverse effects. The investigators hypothesize that an appropriate dosing regimen of anrikefon administered via patient-controlled intravenous analgesia (PCIA) pump, as part of a multimodal analgesic strategy, can specifically target and alleviate visceral pain after laparoscopic surgery, thereby achieving comprehensive postoperative analgesia.

Начало: 14.04.2026 Край: 01.04.2027 Възраст: 18–75 г.

China Peking University First Hospital NCT07525986

Набира участници Фаза 2

Bactericidal Activity and Safety of Nicotinamide in Combination With Bedaquiline, Pretomanid, and Linezolid in Drug-susceptible Pulmonary Tuberculosis

Drug Susceptible Pulmonary Tuberculosis

The purpose of this study is to determine if nicotinamide in combination with bedaquiline, pretomanid, and linezolid, is safe and effective in treating drug-susceptible pulmonary tuberculosis.

Начало: 13.04.2026 Край: 14.06.2027 Възраст: 18–65 г.

South Africa Gates Medical Research Institute NCT07517445

Набира участници Фаза 2

A Phase II Clinical Trial of LBL-024 Combination Drug in Patients With Advanced Solid Tumour[Substudy 04]

Advanced Solid Tumour

An Open-label, Multicenter, Phase II Clinical Study to Evaluate the Efficacy and Safety of LBL-024 in Combination With Other Drugs for the Treatment of Patients With Advanced Solid Tumour.

Начало: 13.04.2026 Край: 30.05.2028 Възраст: от 18 г.

China Nanjing Leads Biolabs Co.,Ltd NCT07390383

Набира участници Фаза 1

A Study of Zovaglutide (ZT002 Injection) in Participants With Impaired Kidney Function and Healthy Participants

Overweight , Obesity

This study is a single-dose, open-label, parallel design phase I clinical study to evaluate the PK characteristics and safety of single subcutaneous injection of ZT002 Injection in participants with different degrees of renal insufficiency and matched participants with normal renal function.

Начало: 13.04.2026 Край: 19.03.2027 Възраст: 18–75 г.

China Beijing QL Biopharmaceutical Co.,Ltd NCT07443059

Набира участници Фаза 2

An Cohort Study on the Safety and Efficacy of XH-02 in Treating Hypoparathyroidism

Hypoparathyroidism

XH-02 is an mRNA nucleic acid drug that expresses PTH in the body following intravenous or subcutaneous injection, providing PTH replacement therapy for patients with hypoparathyroidism. Previous clinical studies have demonstrated the safety of subcutaneously administered XH-02 in several patients with hypoparathyroidism and have yielded clear efficacy results. This study aims to further validate the safety and efficacy of subcutaneously injected XH-02 in the treatment of hypoparathyroidism in a expanded cohort.

Начало: 13.04.2026 Край: 30.07.2030 Възраст: 18–90 г.

China Peking Union Medical College Hospital NCT07540286

Набира участници Фаза 4

ctDNA-guided Addition of Ipilimumab to Patients Receiving Nivolumab and Relatlimab

Metastatic Melanoma Advanced Melanoma

The purpose of this study is to investigate the use of ctDNA measurements to guide first-lien therapy choice for patients with advanced or metastatic melanoma. Primary endpoints include progression-free survival. Secondary study endpoints include objective response rate and incidence and severity of immune-related adverse events.

Начало: 13.04.2026 Край: 01.05.2031 Възраст: от 18 г.

United States NYU Langone Health NCT07504796

Набира участници

HEalthCAre Workers' Health: a Transversal Evaluation

Occupational Health

The research focuses on assessing the overall health of residents at the Cochin Port Royal hospital Group. * physical health * Mental health: detection of signs of anxiety, depression, eating disorders, substance abuse, etc. * Sexual health * Quality of medical care (dental, gynecological) * Knowledge of risk prevention, particularly infectious risks, in the workplace.

Начало: 13.04.2026 Край: 01.06.2027 Възраст: от 18 г.

France Assistance Publique - Hôpitaux de Paris NCT06588621

Набира участници Фаза 2

A Study Evaluating the Safety and Efficacy of JS212 Combination Therapy in Patients With Advanced Esophageal Squamous Cell Carcinoma

Advanced Esophageal Squamous Cell Carcinoma

This study is an open-label, multi-center phase II clinical trial aimed to evaluat the safety and preliminary efficacy of JS212 combination therapy in patients with advanced esophageal squamous cell carcinoma (ESCC).

Начало: 13.04.2026 Край: 01.04.2028 Възраст: 18–75 г.

China Shanghai Junshi Bioscience Co., Ltd. NCT07484724

Набира участници

A Study Investigating the Efficacy and Safety of the Combination of Iparomlimab and Tuvonralimab With or Without Chemotherapy in Second-line and Subsequent Treatments for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

This is a single-arm, open-label, phase II study to evaluate the efficacy and safety of the combination of the antibodies iparomlimab and tuvonralimab, administered with or without chemotherapy, in patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) who have progressed after receiving at least one line of systemic therapy. The study includes a safety run-in phase with approximately three patients, which may be expanded to six if a dose-limiting toxicity is observed. Patients are then assigned to either combination antibody monotherapy or combination antibody plus chemotherapy, based on PD-L1 combined positive score (CPS), symptom burden, disease characteristics and patient preference. Monotherapy involves iparomlimab and tuvonralimab (5 mg/kg on day 1, every 3 weeks). Combination therapy involves the same antibody regimen plus up to six cycles of platinum (carboplatin at an area under the curve (AUC) of 5 or cisplatin at 75 mg/m²) plus docetaxel (75 mg/m²) or paclitaxel (135-175 mg/m²), followed by antibody monotherapy maintenance. The primary objective is to assess the objective response rate (ORR) according to RECIST 1.1. The secondary objectives are to evaluate the disease control rate (DCR), the 6-month progression-free survival (PFS) rate, the 6-month overall survival (OS) rate and the safety profile. Exploratory objectives include the association of tumour biomarkers (PD-L1 expression and tumour mutation burden) with efficacy.

Начало: 13.04.2026 Край: 31.12.2028 Възраст: 18–75 г.

China The Second Affiliated Hospital of Hainan Medical Univer NCT07546383

Набира участници

Safety and Effectiveness of Bambini Kids Robot-Assisted Gait Training (RAGT) in Children With Cerebral Palsy

Cerebral Palsy (CP)

Cerebral palsy (CP) is a common cause of gait impairment in children, leading to limitations in mobility and daily activities. Although conventional physical therapy is widely used, it has limitations in delivering consistent and intensive training. Robot-assisted gait training (RAGT) has emerged as a promising approach to provide repetitive, high-intensity, and task-specific training, with potential benefits in gait function and motor performance. The Bambini Kids exoskeleton is a pediatric robotic device designed to assist lower-limb movements, including hip, knee, and ankle joints, to facilitate more natural gait patterns. This study aims to evaluate the safety and clinical performance of Bambini Kids in children with cerebral palsy and to generate clinical evidence to support its use in real-world rehabilitation settings.

Начало: 13.04.2026 Край: 31.12.2026 Възраст: 2–10 г.

South Korea COSMO ROBOTICS CO., Ltd NCT07539389

Набира участници

Analysis of the Reliability and Validity of Laser Speckle Contrast Imaging

Gingival Vascularization Oral Soft Tissue Wound Healing Laser Speckle Contrast Imaging Periodontal Wound Healing

This study is designed to validate laser speckle contrast imaging (LSCI) as a non-invasive method for measuring superficial gingival blood perfusion. Accurate assessment of vascularization is essential for understanding periodontal and peri-implant wound healing, yet current clinical methods are limited by subjective interpretation and low reproducibility. Repeated LSCI measurements will be performed in healthy gingival tissues and in tissues undergoing different mucogingival healing patterns, including primary and secondary intention healing. The study will also evaluate factors that may influence perfusion readings, such as angulation, retractors, mirror use, temperature, and heart rate. The primary objective is to determine the reproducibility of LSCI measurements and to support its use as a reliable tool for monitoring oral soft-tissue vascularization and healing.

Начало: 13.04.2026 Край: 20.05.2026 Възраст: от 18 г.

Spain Universidad Complutense de Madrid NCT07527351

Набира участници Фаза 1

To Evaluate the Safety, Pharmacokinetic and Pharmacodynamics of JW0061 in Healthy Volunteers

Healthy

This clinical study is a phase 1, randomized, double-blind, placebo-controlled, dose escalation clinical trial to evaluate the safety, pharmacokinetic and pharmacodynamics of JW0061 following topical application in Korean and Caucasians healthy adults.

Начало: 13.04.2026 Край: 30.04.2027 Възраст: 19–55 г.

South Korea JW Pharmaceutical NCT07514780

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