Търсене на изпитвания

Активни:

Намерени 4,781 изпитвания Стр. 22 от 240

Набира участници

Tumor-Lymph Node Mapping

Pediatric Solid Tumors Rhabdomyosarcoma Sarcoma Germ Cell Tumor

The purpose of this study is to assess the feasibility and safety of ICG-guided intraoperative lymphography for detecting sentinel lymph nodes (SLN) in pediatric patients with solid tumors who require retroperitoneal lymph node dissection/sampling. This trial is a single-site cross-sectional study. The injection of ICG directly into lymphatics draining the primary tumor will take place at the time of operation after the patient is under anesthesia.

Начало: 13.04.2026 Край: 30.07.2028 Възраст: 1–17 г.

United States University of Rochester NCT07054944

Набира участници

Diagnostic Performance Of 4D Dynamic LAFOV FDG-PET Acquisition for Differentiation of Residual Disease and Post-radiation Inflammation in Head Neck SCC Treated by Radiotherapy.

Head & Neck Squamous Cell Carcinoma

This multicenter prospective observational study will evaluate the value of dynamic FDG-PET LAFOV imaging during the initial therapeutic assessment of a head and neck cancer 3 months after completion of curative radiotherapy.

Начало: 13.04.2026 Край: 13.06.2029 Възраст: от 18 г.

France University Hospital, Brest NCT07417605

Набира участници

Invasive Home Ventilation in Denmark

Neuromuscular Diseases (NMD) ALS (Amyotrophic Lateral Sclerosis) Spinal Cord Injuries (SCI) Duchenne Muscular Dystrophy (DMD) +4

The aim of this study is to describe national trends over the past 10 years in patients receiving invasive home mechanical ventilation (HMV) in Denmark. This includes indications for invasive HMV, diagnostic groups, and one-year mortality.

Начало: 13.04.2026 Край: 01.09.2028

Denmark Rigshospitalet, Denmark NCT07467187

Набира участници

RATS Sleeve Lobectomy After Neo-Chemo-IO for NSCLC

Stage IIB-III NSCLC Sleeve Lobectomy Robotic Surgery Neoadjuvant Chemoimmunotherapy

The goal of this multicenter prospective observational study is to learn about the surgical difficulty and outcomes of robotic-assisted sleeve lobectomy in patients with non-small cell lung cancer (NSCLC) after neoadjuvant chemoimmunotherapy. The main questions it aims to answer are: What is the rate of unsuccessful robotic-assisted sleeve lobectomy after neoadjuvant chemoimmunotherapy? What factors are associated with unsuccessful surgery? How do surgeons subjectively assess intraoperative difficulty across multiple dimensions during these procedures? In this study, unsuccessful surgery is defined as any of the following: conversion to thoracotomy, incomplete (non-R0) resection, or major postoperative complications. Participants who are scheduled to undergo curative-intent robotic-assisted sleeve lobectomy as part of their routine clinical care after neoadjuvant chemoimmunotherapy will be enrolled from multiple centers. Clinical, intraoperative, pathological, and short-term postoperative data will be collected prospectively. In addition, surgeons will be asked to provide a multidimensional subjective assessment of intraoperative difficulty, including factors such as pleural adhesions, hilar fibrosis, nodal matting, fissure completeness, and vascular inflammation or edema, to better characterize the technical challenges of surgery and their association with perioperative outcomes.

Начало: 13.04.2026 Край: 30.05.2027

China, France, Italy Shanghai Chest Hospital NCT07541521

Набира участници Фаза 2

Efficacy of L-menthol on Breathlessness in Interstitial Lung Disease

Interstitial Lung Disease (ILD)

The purpose of this study is to assess the effect of L-menthol on breathlessness and exercise capacity in patients with Interstitial lung disease (ILD).

Начало: 13.04.2026 Край: 01.05.2027 Възраст: от 18 г.

Sweden Region Skane NCT07398287

Набира участници Фаза 3

DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemotherapy

Small Cell Lung Cancer (SCLC) Extensive-stage Small Cell Lung Cancer (ES-SCLC)

This study is open to adults with advanced small cell lung cancer (SCLC). The purpose of this study is to find out if a study medicine called obrixtamig plus standard treatment (atezolizumab, carboplatin, and etoposide) improves survival when compared to standard treatment alone. Obrixtamig is an antibody-like molecule that may help the immune system fight cancer. Another purpose of the study is to test a medical device being developed to measure levels of the tumour marker DLL3. Participants are put into 2 groups randomly, which means by chance. One group receives obrixtamig and standard treatment. The other group receives standard treatment without obrixtamig. All treatments are given as infusions into a vein. Participants are in the study for up to 3 years. During this time, they visit the study site regularly. Participants in the group receiving obrixtamig stay overnight at the study site following the first 2 obrixtamig treatments. At the visits, doctors check the size of the tumour(s). The results are compared between the 2 groups to see whether the treatment works. The doctors also regularly check participants' health and take note of any unwanted effects.

Начало: 13.04.2026 Край: 30.07.2029 Възраст: от 18 г. Лечение

Argentina, Australia, Austria +40 Boehringer Ingelheim NCT07472517

Набира участници

The Effectiveness and Acceptability of Formal Versus Informal Mindful Self-Compassion for Adolescents

Coping

The goal of this clinical trial is to learn if two types of mindful self-compassion programs work to improve coping in adolescents. The investigators will also learn about adolescents' liking of, and the other potential mental health and academic benefits of, these programs. The main questions this clinical trial aims to answer are: * Do two types of mindful self-compassion programs improve coping in adolescents? * Do two types of mindful self-compassion programs improve mental health (e.g., stress, anxiety, depression) and academic outcomes (e.g., academic engagement) in adolescents? * How satisfactory are two types of mindful self-compassion programs for adolescents? To do this, the investigators will compare adolescents who complete two types of mindful self-compassion programs to adolescents in a "waitlist control" condition (who complete no study tasks during the program period, but will have the opportunity to complete the program at the end of the study). Participants will: * Complete a brief phone interview to confirm their eligibility (15 min) * Complete an online survey including questions about coping, mental health, and academic engagement (30 min) * Complete a live, online, four-week-long mindful self-compassion program OR no study tasks during this four-week period (if randomly assigned to a waitlist condition) * Complete an online survey 1 week after the 4-week period, including questions about coping, mental health, and academic engagement, as well as their liking of the program they completed (if applicable) * Complete an online survey 1 month after the 4-week period, including questions about coping, mental health, and academic engagement * (Waitlist condition only) Have the opportunity to complete one of the two mindful self-compassion programs after the study had ended

Начало: 13.04.2026 Край: 30.04.2027 Възраст: 14–19 г.

United States Cambridge Health Alliance NCT07513220

Набира участници

AI-Assisted Staging and Treatment Decision-Making for Hepatocellular Carcinoma

Hepatocellular Carcinoma (HCC)

The precise treatment of primary hepatocellular carcinoma (HCC) highly depends on accurate disease staging (CNLC, TNM, BCLC) and scientific treatment decision-making, which necessitate the integration of both imaging and clinical baseline data. This study prospectively recruits HCC patients and clinical physicians across different hospital tiers to evaluate the clinical value of a self-developed artificial intelligence (AI) model in assisting multi-dimensional comprehensive assessment and treatment decision-making. Utilizing a Multi-Rater Multi-Case (MRMC) crossover balanced design, the study compares the accuracy of clinical evaluations performed by physicians under "unassisted (without AI)" versus "AI-assisted" conditions. A key focus is to explore whether AI can significantly enhance the comprehensive assessment capabilities of physicians in primary/secondary care hospitals, thereby prospectively reducing diagnostic and therapeutic heterogeneity across different institutional levels.

Начало: 13.04.2026 Край: 20.05.2026 Възраст: от 18 г.

China Beijing Tsinghua Chang Gung Hospital NCT07538882

Набира участници

CGM-Enhanced DPP to Prevent Type 2 Diabetes in Adults With Prediabetes

PreDiabetes

Prediabetes affects over one-third of adults in the United States, placing them at a higher risk for developing type 2 diabetes and heart disease, which can lead to serious health complications and increased medical costs. Although a program called the Diabetes Prevention Program (DPP) has been shown to lower the risk of diabetes through healthy lifestyle changes, many people find it difficult to stick with these changes over the long term. This study seeks to find out if combining DPP coaching with continuous glucose monitoring (CGM) technology can help people stay on track with their health goals.

Начало: 13.04.2026 Край: 01.03.2028 Възраст: от 18 г.

United States State University of New York at Buffalo NCT07140848

Набира участници

ATTITUDES, PERCEPTIONS, AND COMPETENCIES TOWARDS ARTIFICIAL INTELLIGENCE IN ORTHOTICS AND PROSTHETICS

Artificial Intelligence Healthcare Professionals Orthotics and Prosthetics Attitude +3

The aim of this study is to analyze, using a mixed-methods approach, the attitudes, perceptions, levels of technology acceptance, and competencies in the use of generative artificial intelligence among healthcare professionals working in the field of orthotics and prosthetics. The study will reveal how the technological transformation in orthotics and prosthetics is perceived by healthcare professionals, and will also identify the professional requirements, barriers, and opportunities for integrating artificial intelligence technologies into practice. In this way, it aims to provide a scientific reference for decision-makers to support the updating of professional education programs in orthotics and prosthetics, the development of institutional policies, and the wider adoption of AI-supported clinical applications.

Начало: 12.04.2026 Край: 30.06.2026 Възраст: 18–65 г.

Turkey (Türkiye) gizem boztas NCT07547293

Набира участници

Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Cystic Neoplasms and Pancreatic Neuroendocrine Tumors

Endoscopic Ultrasound-Guided Radiofrequency Ablation Pancreatic Neuroendocrine Tumors (pNET) Pancreatic Cystic Neoplasms

The primary aim of this study is to evaluate the technical feasibility and effectiveness of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) in the treatment of pancreatic cystic neoplasms (PCNs) and pancreatic neuroendocrine tumors (pNETs) in patients who are not suitable candidates for surgical treatment or who refuse surgery. EUS-RFA, as a minimally invasive therapeutic option, may potentially reduce the need for intensive imaging surveillance, prevent further progression of these lesions, and serve as a bridging therapy in selected patients for whom surgical intervention may be considered in the future. At the same time, EUS-RFA could contribute to reducing overtreatment, thereby lowering the risk of complications associated with surgical procedures and leading to an overall reduction in healthcare costs. The secondary objectives of the study are to evaluate the safety profile of EUS-RFA, including the incidence and severity of adverse events both in the early postoperative period and during the first year of follow-up, as well as to assess the long-term efficacy of EUS-RFA, including disease progression.

Начало: 11.04.2026 Край: 31.12.2029 Възраст: от 18 г.

Czechia Institute for Clinical and Experimental Medicine NCT07536087

Набира участници Фаза 1/2

A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

The researchers are doing this study to test the safety of ivonescimab given in combination with standard chemotherapy and stereotactic radiosurgery (SRS) in people with non-small cell lung cancer (NSCLC) that has spread to the brain (brain metastases). The researchers will test different doses of the study drug to find the best dose that causes few or mild side effects in participants. Once the dose is found, the researchers will test it in a new group of participants to see if it is effective in treating their NSCLC brain metastases.

Начало: 10.04.2026 Край: 01.04.2028 Възраст: от 18 г.

United States Memorial Sloan Kettering Cancer Center NCT07535463

Набира участници

Efficacy of a Novel Myopia Defocus Spectacle Lens in School-Aged Children

Myopia

This study aims to evaluate the short-term efficacy and safety of a novel, proprietary spectacle lens. Forty myopic participants, aged 6 to 15 years, will be prescribed with the study spectacles for a period of six months. All subjects will be required to attend five scheduled visits. Change in subfoveal choroidal thickness (SfChT), axial length and refraction will be determined.

Начало: 10.04.2026 Край: 01.03.2027 Възраст: 6–15 г.

Hong Kong The Hong Kong Polytechnic University NCT07511387

Набира участници

Comparison of the Analgesic Efficacy of Erector Spinae Plane Block in Breast-Conserving Surgery Versus Serratus Anterior Block Combined With Additional Pecto-Intercostal II Block

Pain Management in Breast Surgery Pain After Surgery Regional Anaesthesia

This prospective randomized study will compare the effects of Erector Spinae Plane Block (ESPB) and Serratus Anterior Plane Block combined with Pectoral Nerve Block Type II (SAPB + PECS II) on intraoperative analgesia and postoperative opioid consumption in patients undergoing breast cancer surgery. Seventy patients (ASA I-III, aged 18-75 years) will be randomized into two groups using the sealed envelope method. Ultrasound-guided blocks will be performed preoperatively by the same anesthesiologist, with Group 1 receiving ESPB and Group 2 receiving a combined SAPB + PECS II technique performed through a single skin puncture (single needle entry site) with sequential injections into the two target fascial planes. All patients will undergo surgery under general anesthesia and receive postoperative analgesia via morphine patient-controlled analgesia. Pain scores and total opioid consumption will be statistically analyzed, with p \< 0.05 considered significant.

Начало: 10.04.2026 Край: 31.07.2026 Възраст: 18–75 г.

Turkey (Türkiye) Kayseri City Hospital NCT07368413

Набира участници Фаза 2

Intravesical GEM/DOCE for HR BCG-Unresponsive NMIBC

Bladder Cancer Non-Muscle Invasive Bladder Cancer (NMIBC) Urothelial Carcinoma Carcinoma in Situ (CIS) +7

The goal of this clinical trial is to learn whether a combination of two chemotherapy drugs, Gemcitabine and Docetaxel, can treat high-grade non-muscle-invasive bladder cancer (HG-NMIBC) in adults whose cancer failed conventional BCG therapy. The drugs are given directly into the bladder (intravesically), one immediately after the other. The study will also assess the safety of this treatment. The main questions it aims to answer are: Can this drug combination effectively treat HG-NMIBC that did not respond to BCG and help prevent the cancer from coming back, offering long-term protection? What side effects or medical issues do participants experience during treatment? Researchers will evaluate this non-surgical approach as a potential alternative to bladder removal surgery (radical cystectomy), with the goal of validating it as a bladder-sparing option in this setting. Participants will: * Go through a screening process, including tumor removal and imaging tests * Receive weekly bladder treatments with Gemcitabine followed by Docetaxel for 6 weeks * If the cancer responds, continue with similar once monthly treatments (maintenance therapy) for up to 2 years * Attend regular check-ups, including bladder exams, urine tests, biopsies, and optional quality-of-life surveys * Possibly receive a second 6-week treatment cycle if the cancer returns early * Be followed for up to 5 years to monitor long-term outcomes

Начало: 10.04.2026 Край: 01.01.2033 Възраст: 18–99 г.

United States Michael A. O'Donnell NCT07322263

Набира участници Фаза 1/2

A Study of Mirdametinib in People With Central Nervous System Tumors

Central Nervous System Tumors Glioma

The purpose of this study to find out whether mirdametinib is a safe and effective treatment for Central Nervous System/CNS tumors (glioma and neurohistiocytosis).

Начало: 10.04.2026 Край: 10.10.2029 Възраст: от 18 г.

United States Memorial Sloan Kettering Cancer Center NCT07539441

Набира участници Фаза 1

A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of AZD4954 and Vice Versa in Healthy Adults

Healthy Participants

The purpose this study is to measure the impact of laroprovstat (AZD0780) on the pharmacokinetics (PK) of AZD4954 and the impact of AZD4954 on the PK of laroprovstat in healthy male and female participants.

Начало: 10.04.2026 Край: 09.07.2026 Възраст: 18–55 г.

United States AstraZeneca NCT07513571

Набира участници

Danicopan PMS in Korea

Paroxysmal Nocturnal Hemoglobinuria

As part of a post-approval commitment, the Korean health authority requests a study to characterize safety and effectiveness in patients who are treated with Danicopan as an add-on to ravulizumab or eculizumab in normal clinical practice settings. This study is designed to assess the known safety profile or identify previously unsuspected adverse reactions and to evaluate the effectiveness of Danicopan under conditions of routine daily medical practice in Korea.

Начало: 10.04.2026 Край: 27.06.2028

South Korea AstraZeneca NCT07457151

Набира участници

Effects of Low-Intensity Blood Flow Restriction Training on Strength and Kicking Performance in Taekwondo Athletes

Physical Performance Athletic Performance

This study aims to investigate the effects of low-intensity blood flow restriction training (LI-BFRT) on lower-limb strength and kicking performance in taekwondo athletes. Blood flow restriction training is a method that partially restricts blood flow to the muscles during exercise, which may improve performance while reducing training load.

Начало: 10.04.2026 Край: 29.06.2026 Възраст: 16–25 г.

China Shanghai University of Sport NCT07538037

Набира участници Фаза 1

Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes

Diabetes Mellitus

The purpose of this clinical study is to find out how NNC0487-0111 affects, how the body uses insulin (a hormone that helps the body control blood sugar) and how well the pancreas works in people living with type 2 diabetes. There are 2 study treatments. Participants will get either NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Начало: 10.04.2026 Край: 06.12.2027 Възраст: 18–75 г.

Germany Novo Nordisk A/S NCT07535307

1 … 20 21 22 23 24 … 240