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Намерени 4,781 изпитвания Стр. 222 от 240

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Prospective Assessment of Cost-effectiveness and Side-effects of Depressive Patients Treated With ECT or TCA

Depressive Disorder, Major

Prospective observational cohort study to determine cost-effectiveness of ECT compared to medication in the treatment of major depressive disorder (MDD) in the Netherlands.

Начало: 01.01.2022 Край: 31.12.2026 Възраст: от 18 г.

Netherlands Radboud University Medical Center NCT05306184

Активно (без набиране) Фаза 3

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)

Non-Transfusion-dependent Alpha-Thalassemia Non-Transfusion-dependent Beta-Thalassemia

The primary purpose of this study was to compare the effect of mitapivat versus placebo on hemolytic anemia in participants with alpha- or beta-non-transfusion dependent thalassemia (NTDT).

Начало: 20.12.2021 Край: 01.12.2028 Възраст: от 18 г.

Brazil, Bulgaria, Canada +15 Agios Pharmaceuticals, Inc. NCT04770753

Активно (без набиране)

Advanced Care Coordination and Enhanced Linkage and Retention Among Transitional Re-Entrants

Hepatitis C

The overarching goal of this study is to develop a peer-based care coordination intervention for individuals with Hepatitis C Virus (HCV) who were recently released from correctional settings to promote linkage to and retention in HCV care. The investigators will assess the existing barriers and facilitators of HCV treatment initiation, HCV treatment completion, and sustained virologic response among individuals recently released from a U.S. jail or prisons in a randomized control trial. This study will assess the feasibility and process measures of a peer-enhanced HCV care coordination intervention among recently incarcerated individuals.

Начало: 17.12.2021 Край: 01.08.2026 Възраст: от 18 г.

United States Montefiore Medical Center NCT04701437

Активно (без набиране) Фаза 3

A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (PATHFNDR-2)

Acromegaly

A randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine (formerly CRN00808; an oral selective nonpeptide somatostatin receptor type 2 biased agonist) in subjects with non-pharmacologically treated acromegaly.

Начало: 17.12.2021 Край: 01.01.2028 Възраст: от 18 г.

Argentina, Brazil, Bulgaria +12 Crinetics Pharmaceuticals Inc. NCT05192382

Активно (без набиране)

Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients

Cognitive Decline Dementia, Vascular Alzheimer Disease Dementia +1

To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular disease in a Phase Ill randomized controlled trial of 250 patients hospitalized for acute ischemic stroke, aged 55 years or older, and without dementia who are discharged home following hospitalization.

Начало: 14.12.2021 Край: 31.07.2026 Възраст: от 55 г.

United States Rush University Medical Center NCT04337255

Активно (без набиране)

BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)

Primary Hyperoxaluria Type 1

The purpose of this study is to describe the natural history and progression of patients diagnosed with PH1, and to characterize the long-term real-world safety and effectiveness of lumasiran.

Начало: 13.12.2021 Край: 01.09.2028

Belgium, Canada, France +8 Alnylam Pharmaceuticals NCT04982393

Активно (без набиране) Фаза 3

Tapinarof for the Treatment of Plaque Psoriasis in Pediatric Subjects

Plaque Psoriasis

This is an open-label, multi-center, Phase 3 study to evaluate tapinarof cream, 1% in pediatric subjects with plaque psoriasis.

Начало: 02.12.2021 Край: 01.10.2026 Възраст: 2–17 г.

Canada, United States Organon and Co NCT05172726

Активно (без набиране) Фаза 3

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)

Transfusion-dependent Alpha-Thalassemia Transfusion-dependent Beta-Thalassemia

The primary objective of this study was to compare the effect of mitapivat versus placebo on transfusion burden in participants with α- or β-transfusion-dependent thalassemia.

Начало: 30.11.2021 Край: 01.06.2029 Възраст: от 18 г.

Brazil, Bulgaria, Canada +16 Agios Pharmaceuticals, Inc. NCT04770779

Активно (без набиране)

REDUCE Trial- Reducing Prolapse Recurrence

Prolapse; Female

This study will examine whether surgeons should add a prophylactic posterior colpoperineorrhaphy to a mesh-augmented apical prolapse repair.

Начало: 23.11.2021 Край: 30.12.2026 Възраст: от 18 г.

United States Northwestern University NCT04880239

Активно (без набиране)

Variation in Humeral Head Bone Marrow Characteristics With Rotator Cuff Repair Healing

Rotator Cuff Tears Rotator Cuff Repairs

This study investigates correlations between humeral head bone marrow characteristics and tendon healing of rotator cuff repairs. The anticipated results would motivate future research aimed to investigate local enrichment or transplantation of connective tissue progenitor cells to augment rotator cuff repair and the pursuit of novel methods of bone marrow screening to preoperatively identify patients with bone marrow characteristics related to rotator cuff repair success or failure.

Начало: 22.11.2021 Край: 30.06.2029 Възраст: 18–75 г.

United States The Cleveland Clinic NCT05106088

Активно (без набиране)

Epidemiological Study of Korean Radiation Workers

Occupational Exposure to Radiation Neoplasms, Radiation-Induced Leukemia, Radiation-Induced Radiation Effects

Health risks of radiation exposure in the moderate-to-high dose range have been well established. However, the risk remains unclear at low-dose ranges with protracted low-dose rate exposure, which is typical of occupational exposure. The purpose of this study is to construct a cohort of Korean radiation workers and to assess health effects associated with occupational radiation exposure. The study population is expected to be about 190,000 Korean radiation workers who have been registered with the Nuclear Safety and Security Commission since 1984. The national dose registry, the national cancer registry, the national vital statistics registry, and the national health insurance data are collected based on the Nuclear Safety Act. Through the linkage of those collected data, we will evaluate radiation-induced health risks including cancer and non-cancer diseases.

Начало: 18.11.2021 Край: 31.03.2031 Възраст: от 16 г.

South Korea Korea Institute of Radiological & Medical Sciences NCT05380570

Активно (без набиране) Фаза 3

A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure

Carcinoma, Non-Small-Cell Lung

The purpose of this study is to assess the efficacy of adding lazertinib to amivantamab, carboplatin, and pemetrexed (LACP/ACP-L dosing strategies) and amivantamab, carboplatin and pemetrexed (ACP) compared with carboplatin and pemetrexed (CP) in participants with locally advanced or metastatic epidermal growth factor receptor (EGFR) Exon 19del or Exon 21 L858R substitution non-small cell lung cancer (NSCLC) after osimertinib failure. The purpose of the extension cohort is to further describe the safety and efficacy for the ACP-L dosing schedule versus ACP with additional data. After completion of the primary analysis, the study may eventually transition to an open-label extension (OLE) or long-term extension (LTE) phase during which participants will have the option to continue their assigned treatment.

Начало: 17.11.2021 Край: 30.11.2027 Възраст: от 18 г.

Argentina, Belgium, Brazil +26 Janssen Research & Development, LLC NCT04988295

Активно (без набиране) Фаза 3

A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders

Age-Related Macular Degeneration Neovascular Age-related Macular Degeneration Wet Macular Degeneration BRVO - Branch Retinal Vein Occlusion +1

The study will compare the safety of ophthalmic bevacizumab in vials versus pre-filled syringes in subjects diagnosed with a retinal condition that would benefit from treatment with intravitreal injection of bevacizumab, including: exudative age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion.

Начало: 15.11.2021 Край: 01.12.2027 Възраст: от 18 г.

United States Outlook Therapeutics, Inc. NCT05112861

Активно (без набиране)

Detection of Plasma DNA Methylation in Peripheral Blood From Patients With Resectable Liver Cancer

Resectable Hepatocellular Carcinoma

This study explores the potential values of a new blood test approach to detect measurable residual disease or early coming back of cancer (recurrence)/cancer growing, spreading, or getting worse (progression) in patients with liver cancer that can be removed by surgery (resectable). The development of novel cancer biomarkers for liver cancer may help in clinical decision making and lead to improvements in patient outcomes by facilitating prediction of the response to specific treatments, improved monitoring of patients on treatment, and better prognostication of patient outcomes, thus improving stratification for clinical trials.

Начало: 06.11.2021 Край: 04.12.2029 Възраст: от 18 г.

United States Mayo Clinic NCT04856046

Активно (без набиране)

AlloSure Lung Assessment and Metagenomics Outcomes Study

Lung Transplant Infection Lung Transplant; Complications Lung Transplant Failure and Rejection

ALAMO is a prospective, multi-center, perspective, registry of patients receiving LungCare™ (AlloSure®-Lung, AlloMap Lung, and HistoMap) for surveillance post-transplant. This study aims to evaluate the diagnostic performance characteristics of AlloSure Lung (dd-cfDNA) to detect a spectrum of rejection (ACR, AMR) and allograft infection (Bacterial, Viral, Fungal, Mycobacterial, Parasitic).

Начало: 29.10.2021 Край: 31.12.2028 Възраст: от 18 г.

Canada, United States CareDx NCT05050955

Активно (без набиране) Фаза 3

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

Atypical Hemolytic Uremic Syndrome

This study aims to evaluate the efficacy and safety of crovalimab in adult and adolescent participants with aHUS.

Начало: 22.10.2021 Край: 20.08.2029 Възраст: от 12 г.

Belgium, Brazil, Canada +13 Hoffmann-La Roche NCT04861259

Активно (без набиране)

EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy

Substance Use Disorders Opioid Use Disorder, Severe Opioid Use Disorder, Moderate

This study is a multi-site, cluster randomized, two group implementation trial comparing a low- versus high-intensity implementation strategy for supporting hospital-based opioid use disorder treatment (HBOT) in community hospital settings where medication for opioid use disorder (MOUD) treatment has not been implemented.

Начало: 22.10.2021 Край: 21.12.2026

United States Gavin Bart NCT04921787

Активно (без набиране)

SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Hypertension Vascular Diseases Cardiovascular Diseases Chronic Kidney Diseases +1

The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be collected from eligible subjects previously treated in the SPYRAL PIVOTAL-SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED studies.

Начало: 20.10.2021 Край: 30.11.2029 Възраст: от 18 г. Лечение

Australia, Belgium, France +8 Medtronic Vascular NCT05198674

Активно (без набиране) Фаза 1

CF33-hNIS-antiPDL1 for the Treatment of Metastatic Triple Negative Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8 Metastatic Triple-Negative Breast Carcinoma Prognostic Stage IV Breast Cancer AJCC v8

This phase I trial tests the safety, side effects, and best dose of CF33-hNIS-antiPDL1 in treating patients with triple negative breast cancer that has spread to other places in the body (metastatic). CF33-hNIS-antiPDL1 is an oncolytic virus. This is a virus that is designed to infect tumor cells and break them down.

Начало: 18.10.2021 Край: 01.03.2027 Възраст: от 18 г.

United States City of Hope Medical Center NCT05081492

Активно (без набиране) Фаза 1

AL101 Before Surgery for the Treatment of Notch Activated Adenoid Cystic Cancer

Adenoid Cystic Carcinoma Metastatic Adenoid Cystic Carcinoma

This phase Ib trial studies the side effects and possible benefits of AL101 before surgery in treating patients with notch activated adenoid cystic cancer. AL101 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving AL101 before surgery may help to control adenoid cystic cancer that has a NOTCH pathway activation.

Начало: 30.09.2021 Край: 31.12.2028 Възраст: от 18 г.

United States M.D. Anderson Cancer Center NCT04973683

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