Търсене на изпитвания

Активни:

Намерени 4,781 изпитвания Стр. 3 от 240

Само по покана Фаза 4

Comparing Outcomes in Patients Who Have Spinal Surgery Who Have No-Ice Cold and Compression Therapy Using the NICE1 Device Versus Standard of Care

Spinal Surgery Spinal Fusion Laminectomy

A two-arm randomized controlled trial design will be used for this study to evaluate health outcomes of patients who receive Nice1 cryotherapy with compression (cryopneumatic) therapy (intervention group) versus those who receive standard of care (usual care group) postoperatively.

Начало: 15.03.2026 Край: 01.03.2028 Възраст: от 18 г.

United States Sarasota Memorial Health Care System NCT07542470

Само по покана

MSCS in BURSTDR Patients

FBSS PSPSII Neuropathic Pain

The patients included in this study have already undergone the process of probe implantation and adjustment to their individually suitable stimulation pattern. Patients will be selected if the probe was implanted 0 - 5 years ago. Patients with implanted percutaneous electrodes (octrodes) and plate electrodes (surgical lead group) will be included in the study. The aim of this study is to investigate whether additional muscle stimulation can optimize the current pain therapy. After being informed about the study and providing informed consent, the questionnaires (baseline) are completed before the start of the study. Then, in addition to the existing BurstDR stimulation, additional muscle stimulation is started twice a day for 30 minutes and continued for 3 months. During this time, the pain values are also determined every 4 weeks using the visual analog scale (VAS), Oswestry Disabillity Index (ODI), EQ5D-5L, Pain Catastrophizing Scale (PCS), Pain Disability Index (PDI), Patient Global Impression of Change (PGIC). At the end of 3 months, the questionnaires are completed again. The VAS values and the values from the questionnaires are compared with the baseline values. In addition, possible side effects and adverse reactions that could be triggered by the stimulation are recorded at this time. This study makes it possible to investigate the combination of pain treatment with BurstDR and simultaneous muscle stimulation with an Octrodes and pentaleads for chronic back pain in a prospective study.

Начало: 15.03.2026 Край: 15.03.2028 Възраст: от 18 г.

Belgium Jessa Hospital NCT07540663

Само по покана

VR-relaxation for ECT-related Anxiety

ECT-related Anxiety

The goal of this clinical trial is to learn if there is an effect of Virtual Reality (VR) based-relaxation on electroconvulsive therapy (ECT)-related anxiety. The main questions it aims to answer are: * Does VR based-relaxation have an effect on anxiety in patients receiving ECT as part of routine clinical care? * Does VR based-relaxation have an effect on stress symptoms and heart rate in patients receiving ECT as part of routine clinical care? * Does depression severity have an effect on the effectivity of VR-based relaxation Researchers will compare VR-relaxation to relaxation breathing exercises and no relaxation to see if VR-based relaxation has an effect on ECT-related anxiety.

Начало: 12.03.2026 Край: 31.12.2032 Възраст: 18–75 г.

Belgium Universitair Ziekenhuis Brussel NCT07546526

Само по покана

Probiotics in COPD: Effects on Symptoms, Lung Function, and Inflammation

COPD COPD (Chronic Obstructive Pulmonary Disease) Probiotic Probiotic Supplement

The goal of this randomized, placebo controlled, double-blind clinical trial is to find out whether a probiotic supplement can help adults with chronic obstructive pulmonary disease (COPD) breathe better and better control their symptoms. The study will try to answer does taking a probiotic supplement, compare with a placebo, reduce shortness of breath, does it improve daily COPD symptoms or change stool patterns by using validated questionnaires; does it affect lung function or inflammation. The results of this study may contribute to a better understanding of the disease, the application of new therapeutic options, and provide a foundation for future research.

Начало: 08.03.2026 Край: 01.12.2030 Възраст: от 18 г.

Croatia University Hospital of Split NCT07339280

Само по покана

Intensive Dialectical Behavior Therapy for Self-Harm and Suicidal Behavior in Youth: A Pilot Study

Self-Harm, Deliberate Suicidal Behavior Borderline Personality Disorder (BPD)

The prevalence of self-harm and suicidal behavior among adolescents has increased dramatically over the past two decades-a fourfold rise that represents both a severe personal burden and a substantial public health challenge. Dialectical Behavior Therapy for Adolescents (DBT-A) is the gold-standard treatment; however, the standard 20-week format is resource-intensive and time-consuming, which limits accessibility. An intensive 4-week DBT (I-DBT) program has been developed that may improve access and reach a larger number of adolescents. The investigators now seek to evaluate its feasibility and preliminary outcomes. The investigators will assess the feasibility of I-DBT in two to three adolescent groups comprising a total of 8-12 participants and their caregivers in spring and autumn 2026, examining recruitment, feasibility, and outcome measures such as self-harm, suicide attempts, acute hospital admissions, depression, and quality of life, as well as treatment dropout. The investigators aim to use the feedback to make necessary adjustments before broader testing of the I-DBT intervention.

Начало: 02.03.2026 Край: 31.03.2027 Възраст: 14–17 г.

Norway Haukeland University Hospital NCT07450105

Само по покана

Pain Science Education for Labour and Postpartum Pain

Adults Female Labour Pain Postpartum Pain +1

This Delphi study aims to establish expert consensus on the role, content, and delivery of pain science education (PSE) for labour and postpartum pain management. Despite the growing application of PSE in other populations, its use in maternity care remains underexplored. Through a three-round electronic Delphi survey, multidisciplinary experts-including physiotherapists, midwives, gynaecologists, pain specialists, nurses, and psychologists-will contribute their perspectives to guide the development of a structured PSE intervention for future clinical testing.

Начало: 01.03.2026 Край: 01.12.2026

United Kingdom Bournemouth University NCT07096661

Само по покана

Telerehabilitation vs. Home Exercise in Piriformis Syndrome: A Comparative Study

Piriformis Syndrome Exercise Training Telerehabilitation

The aim of this study is to compare the effects of asynchronous telerehabilitation and home exercise programs on pain, fear of pain, functionality, and performance in individuals with piriformis syndrome.

Начало: 01.03.2026 Край: 30.05.2027 Възраст: 18–45 г.

Turkey (Türkiye) Hacettepe University NCT07502573

Само по покана

"The Effect of Adductor Canal Block Performed With Postoperative Thigh Tourniquet Application on Pain After Total Knee Arthroplasty"

Total Knee Arthroplasty for Gonarthrosis

The biggest fear for patients undergoing knee replacement surgery is that persistent pain felt at the back of the knee postoperatively. While regional anesthesia is generally successful at numbing the front of the knee, managing pain in the posterior (back) area is not always easy. In this study, we tested a new method designed to alleviate pain in the back of the knee and improve patient comfort.

Начало: 01.03.2026 Край: 16.04.2026 Възраст: 40–85 г.

Turkey (Türkiye) Ankara Etlik City Hospital NCT07539467

Само по покана

0.01% and 0.025% Atropine Eye Drops Combined Auricular Acupoint Stimulation on Myopia Control and Corneal Endothelium Change

Acupressure

This randomized, double-blind, placebo-controlled pilot trial evaluates the efficacy and safety of low-dose atropine (0.01%, 0.025%) combined with auricular acupoint stimulation for myopia control in children. While 0.05% atropine is effective, it may pose corneal toxicity risks, highlighting the need for safer alternatives. Auricular acupuncture has shown potential benefits in systematic reviews. A total of 420 children aged 6-12 will be randomized into six groups receiving different treatments or placebo, with a 12-week follow-up. The auricular Eye Point will be stimulated, and comprehensive visual and ocular assessments will be conducted, including corneal endothelial monitoring. This study aims to determine the synergistic effect of combined therapy and provide a safer treatment option, laying the foundation for future large-scale trials.

Начало: 27.02.2026 Край: 31.03.2027 Възраст: 6–12 г.

Taiwan China Medical University Hospital NCT07537166

Само по покана

Persona SoluTion PPS Femur PMCF

Rhematoid Arthritis Osteo Arthritis of the Knee Traumatic Arthritis of Knee (Diagnosis) Polyarthritis +5

The goal of this study is to generate clinical evidence and evaluate the safety and performance of the Persona® SoluTion® PPS Femurs in the US market, with data supporting global regulatory submissions, including CE marking under EU MDR. The target population consists of adults undergoing knee arthroplasty with the Persona SoluTion femoral component paired with a Medial Congruent (MC) or Posterior Stabilized (PS) articulating surface in line with its current cleared Instructions for Use (IFU). The primary endpoint is the assessment of clinical performance and benefits by evaluating the average change in the KOOS JR score between pre-operative and 2-year post-operative follow-up.

Начало: 26.02.2026 Край: 01.12.2037 Възраст: от 18 г.

United States Zimmer Biomet NCT07286513

Само по покана

Developmental Pilot of Support Groups for Caregivers of Children With DLD

Developmental Language Disorder

The purpose of this study is to test a new support group curriculum that we designed to support parents of children with Developmental Language Disorder (DLD).

Начало: 20.02.2026 Край: 15.06.2026 Възраст: от 18 г.

United States University of Delaware NCT07536217

Само по покана

The Effects of Group Music Therapy on the Emotional Health of Residents in Long-Term Care Facilities: A Pilot Study

Loneliness Negative Affect Music Therapy Long-term Care Facility +1

The goal of this pilot study is to learn whether group music therapy improves the emotional health of residents living in long-term care facilities. It will also examine the feasibility of integrating an artificial intelligence (AI)-based emotion recognition model into routine psychosocial interventions. The main questions it aims to answer are: Does group music therapy improve positive affect and reduce negative affect, depression, and loneliness among long-term care residents? Are AI-based facial emotion recognition results consistent with residents' self-reported emotional assessments? Researchers will use a one-group pretest-posttest quasi-experimental design to evaluate changes before and after a 6-week group music therapy program. The study will also compare subjective questionnaire results with objective facial emotion recognition outputs generated by the PaLI Gemma 2 multimodal model. Participants will: Attend one 60-minute group music therapy session per week for 6 weeks Complete emotional health questionnaires before the first session and after the sixth session Be recorded during sessions using a non-invasive camera system for facial emotion analysis Have their questionnaire results compared with AI-based emotion recognition outputs to evaluate consistency and feasibility This pilot study will provide preliminary evidence regarding both the psychological benefits of group music therapy and the feasibility of applying AI-supported multimodal emotion assessment in long-term care settings.

Начало: 18.02.2026 Край: 31.01.2027 Възраст: от 65 г.

Taiwan Yu Chia Chang NCT07536360

Само по покана

INDUCE: A Prospective 2-Year Spine Registry

Subjects Treated With NMP as Part of Their Spine Surgery Degenerative Disc Disease (DDD)

The primary objective of this prospective, observational registry study is to evaluate the safety and effectiveness of Natural Matrix Protein® (NMP®) when used to promote fusion in the cervical or lumbar spine. The secondary objective is to assess patient reported outcomes following the use of NMP in the treatment of the spine.

Начало: 17.02.2026 Край: 01.01.2029 Възраст: от 18 г.

United States Red Rock Regeneration Inc. NCT06971835

Само по покана Фаза 2

A Multicenter, Randomized, Double-Masked, Placebo-Controlled Pilot Study to Evaluate the Efficacy and Safety of ZOC2017217 in Subjects With Age-Related Cataract

Age Related Cataracts

This is a multicenter, randomized, double-masked, placebo-controlled pilot study conducted in the United States (US) in subjects with age-related cataract in one or both eyes. Approximately 40 subjects with age-related cataract will be stratified by race and Best Corrected Distance Visual Acuity (BCDVA) and randomized (1:1) to active investigational product (IP) or placebo. Subjects will administer their assigned IP in the qualifying eye(s) two times a day (BID) for 24 weeks before being exited from the study. Subjects with new or ongoing ocular adverse events (AEs) at the time of planned study exit will be asked to return 2 weeks later for a safety follow-up evaluation.

Начало: 10.02.2026 Край: 01.05.2027 Възраст: от 50 г.

United States Ocusun Ophthalmic Pharmaceutical (Guangzhou) Co., Ltd. NCT07395986

Само по покана

Lower Intersecting HIV-related Stigmas to Facilitate Treatment as Prevention (LIFT)

Stigma, Social Drug Abuse Illicit HIV (Human Immunodeficiency Virus)

The purpose of this study is to reduce HIV transmission risk among people who inject drugs (PWID) through a multilevel intervention known as LIFT. LIFT intervenes to build intragroup PWID support at the community-level to reduce overall drug use and stigma. LIFT also increases efficacy in navigating HIV services in the presence of structural stigma. Additionally, LIFT intervenes on abstinence-based drug use stigma at the health facility-level to improve clinic policy and staff interactions with clients. This is an implementation study to adapt and pilot a stigma reduction intervention with persons who inject drugs (PWID) in Kyrgyzstan. The intervention includes peer-led group sessions focused on stigma reduction and providing support to increase HIV prevention efficacy. The aim will be to adapt, refine, and pilot the intervention among PWID and methadone maintenance treatment (MMT) clinic staff. Participants will be randomized to the intervention or control arms.

Начало: 09.02.2026 Край: 01.10.2026 Възраст: от 18 г.

Kyrgyzstan University of California, San Diego NCT07541131

Само по покана

Use of Gender, Age, Alfa-fetoprotein (AFP), and Des-gamma-carboxyprothrombin (PIVKA-II) or GAAD Score in Addition to Ultrasound for Surveillance of People At-risk for Developing Hepatocellular Carcinoma in Asia in Order to Detect Early Liver Cancer

Liver Cirrhosis Hepatitis B, Chronic Hepatitis C, Chronic Carcinoma, Hepatocellular

HCC surveillance is currently limited by underutilization and the suboptimal performance of AFP. This prospective, single-arm study investigates whether the GAAD score (Gender, Age, AFP, and PIVKA-II) enhances HCC detection when added to standard-of-care surveillance. High-risk patients will undergo US plus GAAD score testing every six months for two years. The primary analysis compares the relative true positive rate (rTPR) and relative false positive rate (rFPR) of surveillance modalities (US, AFP, GAAD) against combined strategies (US+AFP; US+GAAD), utilizing a 2.57 GAAD cut-off. Secondary endpoints include longitudinal biomarker kinetics, early-stage HCC detection rates, and the impact on downstream imaging (CT/MRI) volume. Ultimately, this study seeks to define the role of GAAD as a surveillance adjunct and inform future clinical guidelines for biomarker-enhanced HCC screening.

Начало: 02.02.2026 Край: 31.07.2030 Възраст: от 18 г.

Thailand Siriraj Hospital NCT07298577

Само по покана

Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders

Major Depressive Disorder (MDD) Schizophenia Disorder Bipolar 1 Disorder Alzheimer Disease +3

This is a prospective observational study to identify sociodemographic factors that predict mental health outcomes in the European population and provide evidence linking common, modifiable sociodemographic risk factors for psychiatric symptoms with biological changes in patients suffering from a mental disorder (MD) or a neurodegenerative disease (ND).

Начало: 01.02.2026 Край: 30.12.2029 Възраст: от 18 г.

Spain Fundació Institut de Recerca de l'Hospital de la Santa NCT07239843

Само по покана Фаза 2

A Study to Evaluate the Safety,Tolerability,Pharmacokinetics and Pharmacodynamics of Cenerimod in Adult Chinese Participants With Moderate-to-severe Systemic Lupus Erythematosus (SLE)

SLE - Systemic Lupus Erythematosus

The goal of this clinical trial is to learn about the safety, how the body processes the drug, and its effects of a drug called cenerimod in adult Chinese participants (aged 18-75) with moderate to severe Systemic Lupus Erythematosus (SLE) who are already receiving standard background therapy. The main questions it aims to answer are: * What is the safety and tolerability of a daily 4 mg dose of cenerimod in Chinese participants with SLE? * How is cenerimod processed by the body (pharmacokinetics) in this population? * What is the effect of cenerimod on the level of lymphocytes in the blood (pharmacodynamics)? This is a single-arm study without a comparison group. Participants will: * Take one 4 mg cenerimod tablet by mouth once daily for up to 12 months. * Continue their stable, pre-existing background SLE medications throughout the study. * Attend regular clinic visits over a period of up to 22 months for tests and check-ups, including blood draws, heart monitoring (12-lead electrocardiogram), vital signs(blood pressure),and physical examinations. * Undergo a final safety follow-up 6 months after their last dose of the study drug.

Начало: 14.01.2026 Край: 08.10.2027 Възраст: 18–75 г.

China Viatris Pharmaceuticals Co., Ltd. NCT07266090

Само по покана

Chitosan Phonophoresis With Recurrent Hamstring Strain in Athletes

Hamstring Injury

The purpose of this randomized controlled trial is to evaluate and compare the effectiveness of adding chitosan phonophoresis as an adjunct to a rehabilitation-based exercise program compared to a rehabilitation-based exercise program with sham chitosan phonophoresis in athletes with recurrent hamstring strain injuries on the following outcomes: Hamstring-specific pain and function, Muscle strength and endurance, Lower extremity functions, Hamstring Flexibility symmetry and Hamstring injury healing score.

Начало: 01.01.2026 Край: 01.03.2027 Възраст: 18–35 г.

Egypt Cairo University NCT07544004

Само по покана

Simulation-Based Childbirth Training and Midwives' Outcomes

Education Maternal Health

This randomized controlled study aims to evaluate the effect of simulation-based childbirth management training on safe motherhood practices and intrinsic motivation among midwives. Participants will be randomly assigned to either an intervention group receiving simulation-based training or a control group receiving no additional training. Outcomes will be assessed using validated scales before and after the intervention.

Начало: 01.01.2026 Край: 01.06.2026 Възраст: 18–45 г.

Turkey (Türkiye) Selcuk University NCT07543133

1 2 3 4 5 … 240