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Намерени 4,436 изпитвания Стр. 30 от 222

Recruiting

Real-World Study of Patients With Type 1 Diabetes Treated With Teplizumab as Part of Managed Access Programs (MAPs)

Type 1 Diabetes

This study is a multi-country, multi-center retrospective observational cohort study based on secondary data collected via chart review, with the aim of describing patient characteristics (including relevant comorbidities), monitoring and treatment practices related to Type 1 diabetes mellitus (T1D) progression, and time to T1D progression in participants who received teplizumab as part of Managed Access Programs (MAPs). This study design was chosen in order to gain rapid insight into the current use of teplizumab in clinical practice and the characteristics of patients who received the treatment.

Начало: 16.03.2026 Край: 30.11.2026

Italy, Spain, United Kingdom Sanofi NCT07457580

Recruiting

GyroStim for Post Concussion Syndrome

Post Concussion Syndrome

The goal of this study is to evaluate the efficacy of using sensorimotor multi-axis automated rotational therapy (SMART) to help treat post concussion syndrome (PCS) in adults. The investigators hypothesize that patients who include SMART therapy as part of their treatment regimen will improve faster than patients who do not include SMART treatment. The investigators hypothesize that patients whose treatment approach includes SMART will improve to a greater extent in their primary outcome measures than patients whose treatment approach did not include SMART. The primary study endpoints are Post Concussion Symptom Scale (PCSS), Headache Impact Severity (HIT-6), Neck Disability Index (NDI), Dizziness Handicap Inventory (DHI), Functional Gait Assessment (FGA), Modified Clinical Test of Sensory Interaction in Balance (CTSIB-m), Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and the Rivermeade Post-Concussion Symptom Questionnaire. These assessments will be performed before, midway, and after intervention. Researchers will compare study endpoints to subjects that proceed with standard of care treatments in physical therapy (PT) and speech therapy/cognitive rehabilitation therapy (ST/CRT). All participants will complete baseline testing in both PT and ST/CRT, and will continue with treatment in each therapy once a week. Intervention subjects will also complete 10 SMART session utilizing GyroStim, at a frequency of 2, 3 or 4 times a week. Follow up testing will happen in PT and ST/CRT after completion of 10 SMART sessions, or during their 6th PT and ST/CRT visit. Statistical analysis will look compare groups to evaluate efficacy of SMART intervention, as well as evaluate efficacy of therapeutic frequency.

Начало: 16.03.2026 Край: 30.09.2027 Възраст: от 18 г.

United States Neuroscience Group NCT07527663

Recruiting

Local Radiofrequency Ablation Plus External Beam Radiation for the Treatment of Painful Thoracic and Lumbar Spine Tumors

Thoracic Neoplasms Lumbar Neoplasm

This study looks at how well a combination of treatments helps reduce pain in people with tumors in the middle and lower back (thoracic and lumbar spine). All participants receive the same treatment, which includes a procedure to stabilize the spine (kyphoplasty), radiofrequency ablation will be with the Osteocool system and radiation therapy. The goal is to see how effective this combined approach is at relieving pain. The purpose of this study is to find out whether combining these three treatments provides better pain relief for patients with thoracic and lumbar spine tumors. This study is for adults who have cancer that has spread to the thoracic or lumbar spine and who report moderate to severe back pain (a pain score of 5 or higher on a 0-10 pain scale).

Начало: 16.03.2026 Край: 01.03.2031 Възраст: от 18 г.

United States UNC Lineberger Comprehensive Cancer Center NCT07479199

Recruiting Phase 1

A Study of ORN252 in Healthy Participants

Healthy Volunteers - Male and Female

The purpose of this study is to assess the safety and tolerability of ORN252 in healthy adult participants.

Начало: 16.03.2026 Край: 01.03.2027 Възраст: 18–55 г. Basic science

Australia Orna Therapeutics, Inc. NCT07439796

Recruiting Phase 1

SAD and MAD Study of AKB-9090 in Healthy Adult Participants

Healthy Volunteers

This is a first-in-human (FIH study designed to evaluate safety, tolerability, pharmacokinetic, and pharmacodynamic effects of AKB-9090 in healthy adult participants. The study consists of two stages: Stage 1, a single ascending dose (SAD) phase with five dose cohorts, and Stage 2, a multiple ascending dose (MAD) phase with three dose cohorts. Approximately 40 participants in SAD and 30 in MAD are planned to be enrolled.

Начало: 16.03.2026 Край: 01.12.2026 Възраст: 18–60 г. Treatment

New Zealand Akebia Therapeutics NCT07429006

Recruiting Phase 3

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

Non-small Cell Lung Cancer (NSCLC)

A study to evaluate Pumitamig versus Durvalumab following concurrent chemoradiation therapy in participants with unresectable stage III Non-small Cell Lung Cancer (NSCLC)

Начало: 16.03.2026 Край: 31.12.2033 Възраст: от 18 г. Treatment

Argentina, Australia, Belgium +27 Bristol-Myers Squibb NCT07361497

Recruiting Phase 3

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

Obesity or Overweight

The purpose of this study is to assess the efficacy and safety of enicepatide, a dual glucagon like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA), at multiple doses compared with placebo for weight management in participants without Type 2 diabetes mellitus (T2DM) who have obesity or overweight with at least one weight-related comorbidity.

Начало: 16.03.2026 Край: 28.08.2028 Възраст: от 18 г. Treatment

Argentina, Australia, Canada +3 Hoffmann-La Roche NCT07351045

Recruiting Phase 1/2

A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)

Hepatocellular Carcinoma (HCC)

The purpose of this study is to evaluate the safety and tolerability of Pumitamig alone or in combination with Ipilimumab in participants with first-line advanced or unresectable Hepatocellular Carcinoma (HCC)

Начало: 16.03.2026 Край: 14.10.2031 Възраст: от 18 г. Treatment

Australia, Chile, China +10 Bristol-Myers Squibb NCT07291076

Recruiting

Effect of Night Guard Use on Masseter Muscle Thickness in Children With Bruxism

Bruxism Bruxism, Sleep-Related

This prospective study aims to evaluate the clinical findings of bruxism and masseter muscle thickness in children aged 10-12 years using ultrasonography, and to assess the effects of night guard use on these parameters over time.

Начало: 15.03.2026 Край: 01.10.2026 Възраст: 10–12 г.

Turkey (Türkiye) Nigde Omer Halisdemir University NCT07548502

Recruiting

Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia

Intraoperative Hypotension

This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia. The main question is : Does the HPI and AFM software reduce the incidence and duration of intraoperative hypotension? Does the HPI and AFM software optimize fluid and vasopressor administration? Does the HPI and AFM software improve perioperative outcomes? Participants will be randomly allocated to either an experimental group receiving goal directed hemodynamic therapy guided by HPI and AFM or a control group receiving conventional hemodynamic management.

Начало: 15.03.2026 Край: 01.03.2027 Възраст: от 18 г.

Greece National and Kapodistrian University of Athens NCT07301307

Recruiting

ICHARUS: Italian Cooperative HemoAdsorption Study for Relief of Uremic Symptoms

Chronic Kidney Disease 5D Uremia; Chronic

Background: Many patients receiving maintenance hemodialysis continue to experience persistent uremic symptoms, such as pruritus, fatigue, sleep disorders, reduced physical performance, and impaired quality of life, despite optimized dialysis prescriptions. Conventional dialysis techniques mainly rely on diffusion and convection and may be insufficient to remove certain uremic toxins, particularly protein-bound and middle-molecule solutes. Purpose: The ICHARUS study (Italian Cooperative HemoAdsorption Study for Relief of Uremic Symptoms) is a prospective, observational, real-world registry designed to evaluate the clinical use of hemodialysis combined with hemoadsorption (HAHD) in patients with persistent uremic symptoms. Study design: ICHARUS is a multicenter registry enrolling adult patients on maintenance hemodialysis in whom hemoadsorption is prescribed according to routine clinical practice. Hemoadsorption is added to standard dialysis sessions without modifying the underlying dialysis modality or prescription. The study does not involve randomization or experimental interventions. Outcomes: The registry will collect data on patient-reported symptoms, quality of life, selected laboratory parameters, and safety outcomes at baseline and during follow-up at 1, 3, and 6 months. The aim is to describe symptom evolution, tolerability, and real-world treatment patterns associated with HAHD. Significance: By collecting standardized real-world data across multiple centers, the ICHARUS registry aims to improve understanding of the potential role of hemoadsorption in chronic hemodialysis, support harmonization of clinical practice, and generate hypotheses for future interventional studies.

Начало: 15.03.2026 Край: 01.07.2027 Възраст: от 18 г.

Italy Azienda Ospedaliera Brotzu NCT07522008

Recruiting

The Influence of Water Intake on Food Intake at Meals Varying in Moisture

Eating Behaviors

The primary purpose of this study is to investigate the influence of including water as a beverage at a meal on food intake, and if the influence of water consumption on food consumption is moderated by switching behavior. Additionally, other individual characteristics will be examined for their influence on the effects of simultaneous variety and portion size on meal intake.

Начало: 15.03.2026 Край: 23.02.2027 Възраст: 20–60 г.

United States Cornell University NCT07439198

Recruiting

Lab Research Using Mini-tumors to Study Prostate Cancer Treatments

Prostate Cancer Prostate Cancer Metastatic Disease Prostate Cancer Recurrent Advanced Prostate Cancer

For men with an aggressive form of prostate cancer, finding the right and effective treatment right away is challenging. Many of these men face a high risk of cancer recurrence: about half experience a relapse after surgery, and more than a third after undergoing radiation therapy. Men with metastatic prostate cancer have particularly poor prognoses, with a five-year survival rate of only 30% to 50%. In short, it is difficult to predict which treatment, or combination of treatments, will lead to longer survival for this group of men with aggressive (metastatic) prostate cancer. In the laboratory, it is possible to grow small samples of tumors into 3D mini-tumors. These mini-tumors retain the characteristics of the patient's original tumor tissue. Various treatments can be tested on these 3D mini-tumors to determine which therapy is most effective for each individual case. There are currently two techniques available for creating these 3D mini-tumors in the lab. In this project, we aim to investigate which of these two techniques works best in order to test and personalize treatments.

Начало: 15.03.2026 Край: 30.12.2031 Възраст: от 18 г.

Netherlands Maastricht Radiation Oncology NCT07004582

Recruiting

POP SINGER Pilot Study

Chronic Pain

Conduct a single-arm pilot study (N = 24) to examine the feasibility and acceptability of the hybrid (i.e., half in-person, half online) POPSINGER group Music Therapy (MT) intervention.

Начало: 13.03.2026 Край: 31.07.2026 Възраст: от 18 г.

United States University Hospitals Cleveland Medical Center NCT07450131

Recruiting

Food Intake and Thermogenesis in High Spinal Cord Injury

SCI - Spinal Cord Injury

The purpose of this research is to determine the effects of food on cardiovascular and metabolic health in men with and without spinal cord injury (SCI).

Начало: 13.03.2026 Край: 31.12.2027 Възраст: 18–65 г.

United States University of Miami NCT07103993

Recruiting

Supraglottic Airway for Resuscitation in Preemies

Respiratory Failure Premature Neonates Delivery Room Resuscitation Positive Pressure Ventilation +4

The goal of this single-arm intervention trial is to learn whether using a supraglottic airway (SA) as the primary interface for positive pressure ventilation (PPV) is feasible during delivery room resuscitation of premature infants. This study will be conducted in premature infants born between 29 0/7 and 33 6/7 weeks' gestation who require PPV at birth. The main question it aims to answer is: Is it feasible to use a supraglottic airway as the primary interface to provide effective PPV during delivery room resuscitation in 29 0/7 to 33 6/7 weeks' gestation premature infants? Participants will (1)Be screened prenatally and have informed consent obtained from the birth parent prior to delivery; (2)Be rescreened for eligibility on the day of delivery before receiving the study intervention; (3)Receive PPV using a supraglottic airway as the primary ventilation interface if resuscitation is required at birth; and (4)Have clinical and procedural data collected during delivery room resuscitation and for up to 24 hours after birth.

Начало: 13.03.2026 Край: 01.10.2026 Възраст: до 1 г.

United States University of Pennsylvania NCT07419438

Recruiting Phase 1

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LWP779 in Healthy Participants

Ischemic Stroke

This study is a randomized, double-blind, placebo-controlled clinical trial featuring both single ascending dose (SAD), food effect and multiple ascending dose (MAD) phases intended to evaluate the safety, tolerability, PK, PD, and active metabolites of LWP779 after oral administration in healthy participants.

Начало: 13.03.2026 Край: 30.09.2026 Възраст: 18–65 г. Treatment

Australia Longwood Pharmaceuticals (Hangzhou) Co., Ltd. NCT07371455

Recruiting Phase 3

Safety of KN057 Prophylaxis in Patients With Haemophilia A or B

Hemophilia A or B

The purposes of this open-label, multicenter III clinical trial are to evaluate the safety and efficacy of long-term preventive treatment with KN057 in Haemophilia A or B patients with or without inhibitors, and to assess the pharmacokinetic characteristics of the new and old processes KN057. The participants in Part PK will be randomly assigned to Old process Group or New process Group in a 1:1 ratio. The participants in Old process Group will receive old process KN057 prophylaxis for the first 26 weeks and new process KN057 prophylaxis for the following 26 weeks. The participants in New process Group will receive new process KN057 prophylaxis for both the first 26 weeks and the last 26 weeks. The participants in Part non-PK will be non-randomized and treated with new process KN057 for 52 weeks prophylaxis after enrollment. Priority screening and enrollment of participants who have participated in the KN057-A-301 or KN057-A-302 study.

Начало: 13.03.2026 Край: 30.03.2028 Възраст: 12–65 г.

China Suzhou Alphamab Co., Ltd. NCT07545395

Recruiting

Impact of Theta Burst Repetitive Transcranial Magnetic Stimulation on the Patient's Self-reported Improvement in Their Motor Functional Neurological Disorder

Functional Neurological Disorder Motor FND

Functional neurological disorder (FND) is a condition that causes significant suffering and disability. It is defined by the presence of neurological symptoms that interfere with an individual's functioning and are not consistent with any known anatomical lesion but that causes significant functional impairment. The investigators are particularly interested in motor symptoms (abnormal movements or motor deficits). Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and acceptable treatment that has proven effective in certain chronic pain conditions, depression, and OCD. The investigators would like to evaluate the impact of rTMS on the patient's overall perception of change, particularly on the clinical symptoms of motor FND. Secondary objectives include evaluating the overall effect on symptoms from the clinician's perspective, the effect on quality of life, on depressive and anxiety symptoms and associated dissociation, as well as evaluating any changes in the sense of agency and identifying the side effects of rTMS treatment.

Начало: 13.03.2026 Край: 01.03.2028 Възраст: от 18 г.

France Hospital Center Guillaume Régnier NCT07527403

Recruiting Phase 2/3

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

The purpose of this study is to evaluate the safety and efficacy of Pumitamig in combination with chemotherapy versus Nivolumab in combination with chemotherapy in participants with previously untreated advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma

Начало: 13.03.2026 Край: 11.09.2032 Възраст: от 18 г. Treatment

Argentina, Australia, Brazil +17 Bristol-Myers Squibb NCT07221149

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