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Electromagnetic Field Therapy Versus Aerobic Exercise on Prostatic Function in Elderly With Benign Prostatic Hyperplasia

Benign Prostate Enlargement

This study will be carried out on seventy five elderly patients with benign prostatic hyperplasia. Their age will range from 60 to 75 years old. They will be recruited from Hoda Talaat Harb geriatric care center, Helwan governorate, Egypt. The aim of this study to investigate the effect of Electromagnetic field versus aerobic exercise on benign prostatic hyperplasia. Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate gland and refers to the stromal and glandular epithelial hyperplasia that occurs in the transition zone of the prostate Clinically, the condition manifests with lower urinary tract symptoms (LUTS) consisting of obstructive (weak urination stream, incomplete bladder emptying, hesitancy) and irritative symptoms (frequency, urgency, nocturia). It is important to note that LUTS can result from a variety of conditions including problems relating to bladder innervation and aging as well as the outflow obstruction caused by BPH. LUTS due to BPH increases with age, BPH was primarily treated surgically for many years, however, in the 1990s this was superseded by the medical approaches that are now the front line therapy. 5α-reductase inhibitors such as finasteride and dutasteride and α-adrenergic blockers such as doxazosin and tamsulosin are used to shrink and relax the organ, respectively. The MTOPS study demonstrated that a combination of the α-blocker Doxazosin and the 5α-reductase inhibitor Finasteride are more effective at reducing LUTS progression than either drug given alone. While these approaches are effective in many patients, a significant proportion, in the range of 35%, showed progressive disease even in the face of the two drug combination,The Electromagnetic field is thought to have the ability to affect the cells that induce different cellular changes , present studies prove that molecular synergies may not remain the unique determinants implicated in the biological interface. EMF possesses numerous well-reported biological effects including inflammation and pain suppression. This therapy is noninvasive, secure, and easy to use for treating the origin of discomfort, damage, and inflammation

Начало: 01.01.2026 Край: 20.04.2026 Възраст: 60–75 г.

Egypt Cairo University NCT07357168

Само по покана

Autoimmune Hyperthyroidism in Prepubertal Children

Autoimmune Hyperthyroidism Children

The investigators propose a multicenter retrospective study to assess clinical, biochemical, and auxological characteristics at diagnosis and during follow-up in a cohort of Caucasian pediatric patients diagnosed with autoimmune hyperthyroidism before puberty. These prepubertal patients will be compared with a control group of post-pubertal patients with Graves' disease. This study aims to enhance the understanding of autoimmune hyperthyroidism in prepubertal patients by providing a detailed evaluation of disease onset, therapeutic response, and growth-related outcomes. The inclusion of a carefully matched post-pubertal control group will allow for robust comparative analysis and identification of age-dependent clinical patterns and prognostic indicators, ultimately supporting more tailored and effective management strategies in pediatric populations at this particular age.

Начало: 01.01.2026 Край: 01.12.2026 Възраст: 2–18 г.

Italy IRCCS Ospedale San Raffaele NCT07544290

Само по покана Фаза 1

Propranolol With Tislelizumab Plus GC in Neoadjuvant Bladder UC

Bladder Urothelial Carcinoma Lymph Node Metastasis

This is a prospective, multicenter, Phase Ib clinical study designed to evaluate the safety and preliminary efficacy of propranolol combined with tislelizumab plus gemcitabine/cisplatin (GC) as neoadjuvant therapy for patients with bladder urothelial carcinoma with clinical lymph node involvement (cT1-T4aN1-3M0). Current neoadjuvant immunochemotherapy regimens can improve clinical outcomes in cisplatin-eligible patients; however, patients with lymph node metastasis show a significantly poorer pathological complete response (pCR) rate compared with non-metastatic cases. Real-world clinical observations have shown that more than 20% of patients achieve complete response in the primary tumor after immunotherapy but have persistent or progressive positive lymph nodes, suggesting unique resistance mechanisms within lymph node metastatic lesions. Preclinical studies conducted by our team demonstrated that sympathetic innervation within lymph nodes releases norepinephrine, which activates β-adrenergic signaling in metastatic tumor cells and promotes lipid metabolic reprogramming, leading to CD8⁺ T-cell exhaustion and immune resistance. Propranolol, a non-selective β-adrenergic blocker, may reduce metabolic stress and restore antitumor immunity, potentially enhancing the efficacy of immune checkpoint blockade. In this study, enrolled patients will receive oral propranolol in combination with intravenous tislelizumab and standard GC chemotherapy prior to surgery. Participants will be closely monitored for treatment-related adverse events, including cardiovascular events, hematologic toxicity, and immune-related reactions. The primary endpoint is dose-limiting toxicity (DLT). Secondary endpoints include pathological complete response (pCR), pathological downstaging, safety, and survival outcomes. Exploratory analyses will evaluate changes in immune cell populations in tumor tissues, lymph nodes, and peripheral blood. The results of this study aim to provide evidence for new neoadjuvant strategies targeting lymph node metastatic bladder cancer and support the development of personalized therapeutic approaches.

Начало: 01.01.2026 Край: 30.06.2029 Възраст: от 18 г.

China Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University NCT07353294

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Virtual Reality-Based Simulation Training for Antegrade Anterior Column Acetabular Screw Placement in Orthopedic Residents

Virtual Reality Simulation

The goal of this study is to find out if virtual reality (VR) training helps orthopedic residents improve their skills in placing screws in the pelvic bone. The study will also compare VR training with standard training to see which method is more effective and easier to use. The main questions it aims to answer are: Does VR training improve performance compared to standard training? Does VR training help reduce procedure time and X-ray use? Do participants prefer VR training? Researchers will compare VR training with standard training using a crossover design, where all participants receive both types of training. Participants will: Take part in both VR and standard training sessions Practice the procedure on a bone model Be evaluated by experts on their performance Complete a satisfaction questionnaire

Начало: 01.01.2026 Край: 01.06.2027

Thailand Bangkok Metropolitan Administration Medical College and NCT07515092

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Unrelated Umbilical Cord Blood Transplantation for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

ALS (Amyotrophic Lateral Sclerosis)

Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder. Its global prevalence is approximately 0.73-1.89 per 100,000 individuals. In China, there are about 200,000 ALS patients, with approximately 25,000 new cases diagnosed annually. Microglia, the resident immune cells of the central nervous system (CNS), rapidly transition from a resting state to a pro-inflammatory phenotype (M1) in ALS. This activation leads to the release of a large number of inflammatory factors (such as TNF-α, IL-1β, IL-6, NO, ROS) and chemokines (such as MCP-1/CCL2), and triggers the NLRP3 inflammasome. Furthermore, systemic immune dysregulation plays a significant role in the pathogenesis of ALS. ALS patients exhibit reduced numbers of regulatory T cells (Tregs), alterations of activated CD8+ T cell infiltrates, and a shift in the helper T cell (Th1/Th2) balance towards the pro-inflammatory Th1 phenotype. In recent years, therapeutic strategies targeting novel pathways such as neuroinflammation, immune dysregulation, and energy metabolism have emerged, including the infusion of Tregs, mesenchymal stem cells (MSCs), and neural stem cells. However, these approaches have still failed to halt disease progression \[NCT05695521, NCT03280056, NCT06973629, NCT02290886\]. Recent research suggests that hematopoietic stem cell transplantation (HSCT) may disrupt the activation cycle between astrocytes and microglia, alleviate chronic inflammatory states in the CNS, partially mitigate mitochondrial dysfunction, and thereby slow neurodegeneration. Unrelated umbilical cord blood transplantation offers advantages such as low HLA-matching requirements, a lower risk of graft-versus-host disease (GVHD), a potent graft-versus-leukemia (GVL) effect, and immediate availability. Investigators plan to conduct an exploratory clinical trial to evaluate the safety and efficacy of umbilical cord blood transplantation for ALS patients. The preliminary plan is to enroll 8 adult subjects. Following successful neutrophil engraftment (defined as an absolute neutrophil count ≥0.5×10⁹/L for three consecutive days) and confirmation of complete donor chimerism. The trial will focus on assessing transplantation-related complications and patient tolerance. A 3-month post-transplantation follow-up will be conducted for a comprehensive evaluation of safety and efficacy for ALS patients.

Начало: 29.12.2025 Край: 01.12.2027 Възраст: 35–50 г.

China Institute of Hematology & Blood Diseases Hospital, Chin NCT07539662

Само по покана

A Long-term Observational Study in Participants Who Have Received PBGENE-HBV

Chronic HBV Infection

Participants who received at least one dose of PBGENE-HBV will be enrolled in this LTFU study.

Начало: 25.12.2025 Край: 01.06.2040 Възраст: 19–80 г.

Hong Kong, Moldova, New Zealand +1 Precision BioSciences, Inc. NCT07254208

Само по покана Фаза 4

Comparing Treatment of Knee Osteoarthritis With Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance

Knee Arthritis Osteoarthritis

The purpose of this study is to determine whether a lower dose of corticosteroid injection with ultrasound-guidance for the treatment of knee osteoarthritis can be as effective as a higher dose that is landmark-guided. With landmark-guided dosing, it may be reasonable to use a higher amount of corticosteroid in order to ensure a sufficient amount of the medication is administered, however these injections carry the risk of side effects. Alternatively, with the use of ultrasound, it may be reasonable to use less corticosteroid, possibly decreasing the risk of side effects and increasing patient satisfaction.

Начало: 12.12.2025 Край: 08.12.2026 Възраст: от 50 г.

United States Sosi Dzhugarian NCT07544576

Само по покана

Evaluation of the Efficacy and Safety of Palmitoleic Acid Oil Composition in Preventing Pressure Injuries

Pressure Ulcer Prevention

To evaluate the efficacy and safety of a topical palmitoleic acid (POA) oil composition in preventing PIs and reversing Stage I damage using an integrated physiological monitoring approach.

Начало: 01.12.2025 Край: 01.12.2026 Възраст: от 18 г.

China Ruijin Hospital NCT07547254

Само по покана Фаза 1/2

Intervention of Ovarian Cancer With Antigen-specific Engineered Immune Effectors

Ovarian Cancer

This is a single-arm, open-label, phase I/II trial to evaluate the safety and efficacy of ovarian cancer-specific, engineered immune effectors (OC-EIEs) in women.

Начало: 01.12.2025 Край: 31.12.2028 Възраст: 10–80 г.

China Shenzhen Geno-Immune Medical Institute NCT03393962

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Optical Coherence Tomography in Acute Vessel Evaluation

Ischemic Heart Disease Ischemic Coronary Artery Disease ACS (Acute Coronary Syndrome)

The purpose is to investigate if a strategy of routine OCT based diagnosis and guidance of PCI improves clinical outcomes compared with a standard strategy of guidance by angiography in patients presenting with ACS

Начало: 23.11.2025 Край: 01.09.2039 Възраст: от 18 г.

Belgium, Denmark, Estonia +9 Aarhus University Hospital Skejby NCT07422688

Само по покана

Minimally Invasive Molecular Approaches for the Detection of Barrett's Esophagus- High Grade Dysplasia and Esophageal Adenocarcinoma

Barrett Esophagus Esophageal Adenocarcinoma

This study explores the use of a minimally invasive screening tool (a sponge on a string device) to detect Barrett's esophagus and esophageal adenocarcinoma and to develop a laboratory test for the detection of Barrett's esophagus-high grade dysplasia and esophageal adenocarcinoma.

Начало: 17.11.2025 Край: 31.07.2030 Възраст: 18–90 г.

United States Mayo Clinic NCT07212491

Само по покана Фаза 3

Phase 3, Open Label Extension Study of ACP-204 in Lewy Body Dementia Psychosis

Lewy Body Dementia Psychosis

A 52-Week, Phase 3, Open-Label Extension Study of ACP-204 in Adults With Lewy Body Dementia Psychosis (LBDP)

Начало: 14.11.2025 Край: 01.03.2029 Възраст: 55–84 г.

Czechia, United States ACADIA Pharmaceuticals Inc. NCT07095465

Само по покана Фаза 3

A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Psoriatic Arthritis

Arthritis, Psoriatic

This is a study to demonstrate the long-term safety, tolerability and clinical efficacy of sonelokimab in the treatment of patients with psoriatic arthritis who completed a parental study (M1095-PSA-301 or M1095-PSA-302)

Начало: 13.11.2025 Край: 04.02.2028 Възраст: от 18 г.

United States MoonLake Immunotherapeutics AG NCT07223138

Само по покана

Music Therapy in Patients With Breast Cancer (IMPACT)

Breast Cancer

This study aims to evaluate the feasibility and potential benefits of music therapy in patients with breast cancer undergoing adjuvant chemotherapy. Breast cancer patients often experience significant physical and psychological symptoms during treatment, including anxiety, fatigue and reduced quality of life. Music therapy is a promising non-pharmacological intervention that may help improve psychological well-being and symptom management. However, current evidence is mainly based on group-level studies and does not account for individual variability in response. This pilot study is designed as a series of combined N-of-1 trials, in which each participant alternates periods with and without music therapy, acting as her own control. A total of 24 patients will be recruited from two Italian oncology centres and randomly assigned to different intervention sequences. The intervention consists of weekly group music therapy sessions lasting approximately 60 minutes, including both active and receptive techniques, along with personalized music playlists for home use. The primary objective is to assess the feasibility of this study design, including recruitment, retention, data completeness and acceptability of the intervention. Secondary objectives include exploring the effects of music therapy on psychological and physical well-being, as well as estimating variability in individual responses. The results of this study will inform the design of future larger studies aimed at evaluating the effectiveness of music therapy using personalised trial approaches.

Начало: 12.11.2025 Край: 30.06.2026 Възраст: 25–75 г.

Italy Istituto di Studi Superiori Musicali (ISSM) Conservator NCT07549685

Само по покана

Improving Prison Health Equity Through Cancer Literacy and Screening Awareness in Florida

Hematopoietic and Lymphatic System Neoplasm Malignant Solid Neoplasm

This study evaluates cancer screening awareness, personal and family cancer history, and barriers to screening among incarcerated women at Gadsden Correctional Facility. The information will be used to inform the content of a tailored digital educational module on screenable types of cancer, their risk factors, and current screening guidelines that will be disseminated to US prisons and incorporated into release programs and general health literacy programs.

Начало: 10.11.2025 Край: 30.10.2027 Възраст: от 18 г.

United States Mayo Clinic NCT07215039

Само по покана

Sleep Health in Pregnant Women in ENRICH

Pregnancy Sleep

This proposal will study sleep health in pregnant women who are of low socioeconomic status (SES) and are participating in the NHLBI-funded UH3 grant: "Enhancing Cardiovascular (CV) Health in Mothers and Children Through Home Visiting (ENRICH)". Objective sleep health will be measured using an in-home sleep disordered breathing testing device and actigraphy and associations of sleep health with social determinants of health and CV health will be investigated. Data from this study will serve as the foundation for future work that will result in the development of sleep interventions and updated guidelines for screening and treatment of sleep in pregnancy.

Начало: 03.11.2025 Край: 01.08.2026 Възраст: от 18 г.

United States Washington University School of Medicine NCT07216287

Само по покана

Efficacy and Safety of Temporal Interference Stimulation on Cognitive Function in Patients With Early-Stage Alzheimer's Disease

Alzheimer Disease

This study aims to investigate the efficacy and safety of a novel non-invasive brain stimulation technique-Temporal Interference Stimulation (TIS)-in patients with early-stage Alzheimer's disease. A total of 40 participants will be randomly assigned to either the TIS group or the sham stimulation group. The intervention will last for 2 weeks, with cognitive and safety assessments at baseline, post-treatment, and 12 weeks after treatment.

Начало: 01.11.2025 Край: 30.09.2027 Възраст: 50–75 г.

China Ruijin Hospital NCT07543094

Само по покана Фаза 4

Efficacy and Safety of Intraosseous Antibiotic Prophylaxis in Total Hip Replacement: A Prospective Randomized Controlled Trial

Antibiotic Prophylaxis Surgery

The goal of this clinical trial is to learn if intraosseous antibiotic (cefazolin) administration can improve antibiotic levels in adults undergoing primary total hip replacement. The main question it aims to answer is: • Does intraosseous cefazolin increase antibiotic concentrations in blood and tissue compared with standard intravenous cefazolin alone? Researchers will compare patients receiving intraosseous cefazolin plus standard intravenous cefazolin to those receiving placebo injection plus standard intravenous cefazolin to see if local antibiotic delivery improves outcomes. Participants will: * Receive standard intravenous cefazolin before surgery and either intraosseous cefazolin or placebo * Provide blood samples before and after antibiotic administration * Have small tissue samples collected during surgery * Complete routine postoperative follow-up and outcome assessment for 90 days

Начало: 20.10.2025 Край: 01.11.2026 Възраст: от 18 г.

United States Rutgers, The State University of New Jersey NCT07549542

Само по покана

The Effects of a Nurse-led TGA-based Pre-rehabilitation Planning on Perioperative Outcomes in Patients With Liver Cancer: Study and Protocol

Liver Cancer

The goal of this clinical trial is to to learn if the nurse-led TGA-based Pre-rehabilitation planning can improve compliance, preoperative functional reserve, and reduce the incidence of postoperative complications in patients with hepatocellular carcinoma. The main questions it aims to answer are: 1. Can this pre-rehabilitation program improve patients' perioperative motor function? 2. Can this pre-rehabilitation program enhance patients' perioperative nutritional status? 3. Can this pre-rehabilitation program improve patients' psychological state? 4. Can this pre-rehabilitation program increase patients' overall compliance? Meanwhile, secondary outcome indicators included complication incidence rate, 30-day readmission rate, first anal flatus passage time, hospitalization duration, serum prealbumin, serum albumin, prothrombin time, total bilirubin, satisfaction and quality of Life. Researchers will compare the control group received only ERAS care after the patient's admission to see if the program is effectiveness. Participants who received the intervention group protocol will initiate pre-rehabilitation measures more than 7 days prior to hospital admission, including nutritional support, exercise and respiratory function training, psychological empowerment, pain pre-management, and smoking/alcohol cessation. These interventions will be recorded daily according to the achievement thresholds established by the research team based on outpatient assessment results. After admission, the patients in this group will receive the same EARS care as the control group.

Начало: 08.10.2025 Край: 30.10.2027 Възраст: 18–84 г.

China Fudan University NCT07537205

Само по покана

VALIDITY AND RELIABILITY OF THE TURKISH VERSION OF THE SEX PAIN QUESTIONNAIRE

Fibromyalgia Neck Pain Musculoskeletal Back Pain Lower Back Chronic Musculoskeletal Diseases

Although there are many questionnaires used in the literature regarding sexual function and satisfaction, these questionnaires evaluate sexual problems regardless of the chronic pain condition and have not been validated for chronic pain. It has been reported that developing a standard or consensus-determined measure to evaluate sexual health in musculoskeletal pain would be advantageous for clinical practice and research. For this purpose, the only study we encountered in the literature is the Sexual Functionality in Chronic Primary Pain Conditions: Sex Pain Questionnaire developed by Rafael Ballester-Arnal in 2022. The questionnaire, consisting of 17 items, comprises two factors: "Sexual and relationship dissatisfaction" and "The effect of chronic pain on sexual life" and has good psychometric properties (Internal consistency indices of 0.72 and 0.96). This study was planned to establish the Turkish validity and reliability of the Sexual Functionality in Chronic Primary Pain Conditions: Sex Pain Questionnaire, which was developed to identify sexual function problems that are impaired due to physical pain in patients with chronic pain, and to contribute it to the literature.

Начало: 01.10.2025 Край: 20.11.2026 Възраст: от 18 г.

Turkey (Türkiye) Kutahya Health Sciences University NCT07536672

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