Search trials – HealthDB

Активни:

Намерени 4,781 изпитвания Стр. 6 от 240

By invitation only Phase 1

Assessing the Efficacy of Repeat, Monthly Treatments of Deoxycholate for NF1 Associated Cutaneous Neurofibromas (cNFs)

Neurofibromas, Cutaneous Neurofibromatosis 1

The goal of this clinical trial is to evaluate the tolerability and effectiveness of multiple treatments of an FDA-approved drug in those with Neurofibromatosis Type 1 (NF1) Cutaneous Neurofibromas (cNFs). The main questions it aims to answer are: Will performing: * Up to 6 months treatment sessions * A minimum of 30 days apart * With up to 50 injections of deoxycholate into a maximum of 50 cNFs in a single region of the body (for a maximum total dose of 10 mL per monthly treatment session) result in tolerable local skin reactions and reduction in both individual cNF size by \>50% as well as improved cNF appearance in the treated field? Researchers will compare treated tumors and control tumors to see if the treatment is effective. Participants will: * Receive up to 6 monthly treatments with Kybella (deoxycholate). Treatment for a given tumor will be stopped when the tumor is assessed as clear clinically. * Complete surveys asking about pain during and after treatments. * Complete surveys asking about satisfaction with the treatments. * Undergo 2D photography and 3D imaging of treatment areas. * Optionally, receive biopsies of up to 6 treated lesions to investigate characteristics of tumors that respond well to treatment as well as non-respondent tumors.

Начало: 08.04.2025 Край: 01.02.2027 Възраст: 18–85 г.

United States Massachusetts General Hospital NCT06300502

By invitation only Phase 3

Long-term Safety and Efficacy Study of Riliprubart in Participants With CIDP

Polyneuropathy, Inflammatory Demyelinating, Chronic

This study is a Phase 3 extension, global, multicenter open-label study. The purpose of this study is to evaluate long-term safety and efficacy of riliprubart in adult participants with chronic inflammatory demyelinating polyneuropathy (CIDP) who have completed Part B in 1 of 3 parent studies (PDY16744, EFC17236, or EFC18156) and wish to continue treatment with riliprubart. Up to approximately 300 participants will be enrolled to continue receiving treatment with riliprubart. The duration of participation for each participant will be up to approximately 4 years, including posttreatment follow-up. The treatment duration will be up to approximately 3 years. A participant who discontinues riliprubart treatment at any time during the study will be followed for safety for a minimum of 55 weeks after the last dose of riliprubart received.

Начало: 01.04.2025 Край: 03.10.2029 Възраст: от 18 г.

Argentina, Brazil, Canada +16 Sanofi NCT06859099

By invitation only

Alleviant ALLAY-HFrEF Study

Heart Failure

Prospective, multicenter, randomized, sham-controlled, double blind (patient and observer), study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFrEF.

Начало: 10.03.2025 Край: 01.12.2028 Възраст: от 18 г. Treatment

Australia, Belgium, Canada +7 Alleviant Medical, Inc. NCT06812533

By invitation only

Probing the Role of Feature Dimension Maps in Visual Cognition: Manipulations of Relevant Locations on Salience Processing? (Expt 3.1 Pilot)

Basic Science: Visual Attention in Healthy Participants Attention

How do we know what's important to look at in the environment? Sometimes, we need to look at objects because they are 'salient' (for example, bright flashing lights of a police car, or the stripes of a venomous animal), while other times, we need to ignore irrelevant salient locations and focus only on locations we know to be 'relevant'. These behaviors are often explained by the use of 'priority maps' which index the relative importance of different locations in the visual environment based on both their salience and relevance. In this research, we aim to understand how these factors interact when determining what's important to look at. Specifically, we are evaluating the extent to which the visual system considers locations that are known to be irrelevant when considering the salience of objects. We're testing the hypothesis that the visual system always computes maps of salient locations within 'feature maps', but that activity from these maps is not read out to guide behavior for task-irrelevant locations. We'll have people look at displays containing colored shapes and/or moving dots and report aspects of the visual stimulus (e.g., orientation of a line within a particular stimulus). We'll measure response times across conditions in which we manipulate the presence/absence of salient distracting stimuli and provide various kinds of cues about the potential relevance of different locations on the screen. The rationale is that by measuring changes in visual search behavior (and thus inferring computations performed on brain representations), we will determine how these aspects of simplified visual environments impact the brain's representation of important object locations. This will support future studies using brain imaging techniques aimed at identifying the neural mechanisms supporting the extraction of salient and relevant locations from visual scenes, which can inform future diagnosis/treatment of disorders which can impact our ability to perform visual search (e.g., schizophrenia, Alzheimer's disease).

Начало: 06.02.2025 Край: 01.02.2027 Възраст: 18–55 г.

United States University of California, Santa Barbara NCT06852521

By invitation only

The ION Facet Screw System Ambispective Evaluation

Intra-facet ION 3D Facet Screw System

The purpose of this observational, multi-center, ambispective, serial case study is to collect real-world patient outcomes that characterize the long-term safety and effectiveness of the SurGenTec ION 3D® Facet Screw System in a cervical spine and a lumbar spine application.

Начало: 31.01.2025 Край: 01.12.2026 Възраст: 21–80 г.

United States SurGenTec LLC NCT06720948

By invitation only

Validity and Reliability of the Turkish Version of the 4-Item Short Form of the Pain Anxiety Symptom Scale

Scale Reliability Validity

The primary aim of the study was to determine the reliability and validity of the Turkish version of the 4-Item Short Form of the Pain Anxiety Symptom Scale. The secondary aim of the study was to determine the level of pain-related anxiety in individuals with chronic pain.

Начало: 29.01.2025 Край: 30.07.2026 Възраст: 18–65 г.

Turkey (Türkiye) Kirsehir Ahi Evran Universitesi NCT06758973

By invitation only

Investigation of Filaggrin Gene Mutations Among Latinx Patients With Atopic Dermatitis

Atopic Dermatitis Eczema

The study, Investigation of Filaggrin Gene Mutations among Latinx patients with Atopic Dermatitis, will examine the association between pathogenic FLG LOF variants and AD in a new population of Latinx patients for which clinical and disease characteristics will be well-described.

Начало: 23.01.2025 Край: 31.12.2027

United States University of Pennsylvania NCT06464133

By invitation only

Morphological-Gene-Clinical Phenotype Correlation Study of the Long Anterior Zonule

Long Anterior Zonules

Long anterior zonules (LAZ) is an anatomical anomaly of the anterior segment in which zonular fibers extend abnormally forward onto the anterior lens capsule. It is potentially associated with glaucoma, late-onset retinal degeneration, and increased risks during cataract surgery. This study introduces a 3D visualization system to enhance the detection rate of LAZ. By integrating multiple imaging modalities, it systematically assesses the morphological characteristics of LAZ, aiming to provide an evidence-based foundation for subsequent efforts to establish diagnostic consensus, optimize preoperative assessments for glaucoma and cataract surgery. By elucidating the genetic mechanisms and genotype-phenotype correlations of LAZ, this research can provide theoretical support for the early identification of high-risk populations, genetic consultation, and personalized treatment.

Начало: 10.01.2025 Край: 31.12.2028 Възраст: от 18 г.

China Fuzhou Eye Hospital NCT07549711

By invitation only

Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment

Periodontitis Smoking Cessation Tobacco Dependence

Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment

Начало: 06.01.2025 Край: 01.06.2029 Възраст: от 18 г.

Belgium University of Liege NCT07491627

By invitation only

Band Versus Ring for Tricuspid Regurgitation

Tricuspid Regurgitation

Tricuspid regurgitation is common in patients with heart valve disease, both flexible band and rigid ring annuloplasty can correct this anomaly. However, there is no data to address which one can bring more benefits to these patients with combined heart valve disease. This study aims to prospectively compare the efficacy and long term outcomes of flexible band versus rigid ring annuloplasty for the correction of tricuspid regurgitation.

Начало: 01.01.2025 Край: 31.12.2028 Възраст: 18–70 г.

China Nanjing Medical University NCT04093297

By invitation only Phase 4

TAF vs TDF During the Pregancy

Hepatitis B Virus Infection; Pregnant Women

The goal of this clinical trial is to learn the efficacy and safety of Tenofovir alafenamide (TAF) vs Tenofovir disoproxil fumarate(TDF) in early and middle pregnancy antiviral therapy for chronic hepatitis B pregnant women. The main questions it aims to answer are: The rate of HBV mother-to-child transmission between the TAF and TDF groups. The incidence of birth defects in newborns between the TAF and TDF groups. What medical problems do participants have when taking drug TAF or TDF? The growth and development indices of newborns between the TAF and TDF groups. Participants will: Take drug TAF or TDF every day during the pregnacy. Visit the clinic once every 4 weeks for checkups and tests during the pregnancy and every 12 weeks postpartum.

Начало: 27.12.2024 Край: 01.12.2029 Възраст: 20–40 г.

China The Third Affiliated Hospital of Guangzhou Medical Univ NCT07542951

By invitation only

Validity and Reliability of the MAP-Hand Scale in Patients With Carpal Tunnel Syndrome

Carpal Tunnel Syndrome (CTS)

The primary aim of the study was to determine the validity and reliability of the "MAP-Hand (Measure of Activity Performance of the Hand)" scale in patients with carpal tunnel syndrome. The secondary aim of the study was to evaluate the hand activity performance in patients with carpal tunnel syndrome.

Начало: 10.12.2024 Край: 01.08.2026 Възраст: 18–65 г.

Turkey (Türkiye) Kirsehir Ahi Evran Universitesi NCT06758193

By invitation only

Validity and Reliability of the Turkish Form of the Knowledge Assessment Scales for Dementia and Urinary Incontinence

Urinary Incontinence in Old Age Dementia

The primary aim of the study was to determine the Turkish version of the "Validity and Reliability of the Knowledge Assessment Scales for Dementia and Urinary Incontinence in Community Older People". The secondary aim of the study was to measure the knowledge level of dementia and urinary incontinence in the community-living elderly population.

Начало: 08.12.2024 Край: 10.08.2026 Възраст: 55–70 г.

Turkey (Türkiye) Kirsehir Ahi Evran Universitesi NCT06758219

By invitation only Phase 3

An Open-label Extension Study to Evaluate Subcutaneous Zilucoplan in Pediatric Participants With Generalized Myasthenia Gravis

Generalized Myasthenia Gravis

The purpose of this study is to assess the long-term safety and tolerability of an additional 52 weeks of Zilucoplan treatment administered by subcutaneous injection once daily in pediatric study participants

Начало: 19.11.2024 Край: 19.11.2027 Възраст: от 12 г.

Italy, Poland, South Korea +1 UCB Biopharma SRL NCT06435312

By invitation only

Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

Depression

In a sample of patients already receiving ketamine (or esketamine) treatment as part of their clinical care, this project seeks to test whether we can enhance and/or extend (es)ketamine's rapid effects by introducing helpful information delivered by a computer-based cognitive training protocol. This work could ultimately lead to the ability to treat depression more efficiently and with broader dissemination by rapidly priming the brain for helpful forms of learning.

Начало: 12.11.2024 Край: 31.05.2029 Възраст: 18–80 г.

United States University of Pittsburgh NCT06526078

By invitation only Phase 2

The Unique and Combined Effects of Prenatal and Early Childhood Programming on Child Maltreatment: Examining Mechanisms of Change

Child Abuse Intimate Partner Violence Secondary Prevention Parenting

Child maltreatment and child exposure to adult intimate partner violence (IPV) often co-occur and are detrimental to the mental and physical health of children, yet few prevention programs address these intersecting forms of adversity using dual-generation approaches. The proposed study is a rigorous randomized controlled trial that uses a 2x2 factorial design to evaluate the potential synergistic benefits of delivering programming prenatally and during early childhood in order to support the mother-child relationship and ultimately prevent child maltreatment. If effective in preventing child maltreatment, these programs have the potential for high public health impact given that they are both cost-effective and readily scalable.

Начало: 07.11.2024 Край: 31.08.2029 Възраст: от 3 г.

United States University of Notre Dame NCT06732310

By invitation only

Is Gender a Factor in Patients With Subacromial Shoulder Pain?

Subacromial Pain Syndrome

This study aimed to investigate the effects of gender on pain, functionality, range of motion, disability level and position sense parameters in patients with subacromial shoulder pain.

Начало: 25.10.2024 Край: 17.09.2026 Възраст: 18–65 г.

Turkey (Türkiye) Kirsehir Ahi Evran Universitesi NCT06758986

By invitation only

Study of a Diabetes Prevention Patient Activation Clinical Decision Support Tool

PreDiabetes Lifestyle, Healthy Activation, Patient

The investigators overarching goal is to increase the percentage of patients engaging in diabetes prevention activities to reduce the incidence of diabetes. The investigators objective is to design and pilot test a prediabetes clinical decision support (CDS) tool in the electronic health record (EHR) that will assess the patient's activation level based on responses to a questionnaire. Based on the patient's assessed level of activation, the tool will generate several communication recommendations to guide clinicians in conversations related to prediabetes/lifestyle change and tailor recommendations about available resources (e.g., care manager, health coach, DPP) to support patient activation.

Начало: 01.07.2024 Край: 01.12.2026 Възраст: от 18 г.

United States Johns Hopkins University NCT06358261

By invitation only

Gadopiclenol vs Gadoxetate MRI for Liver Lesions

Liver Lesion

The overall purpose of this study is to establish noninferiority of gadopiclenol MRI compared to gadoxetate MRI in terms of image quality and lesion detection/conspicuity in patients undergoing clinically indicated liver MRI in a prospective study. The research will be utilizing MRI; with enrollment goal of 75 subjects over the course of two years.

Начало: 01.07.2024 Край: 01.01.2027 Възраст: 18–89 г.

United States Icahn School of Medicine at Mount Sinai NCT06596616

By invitation only

Causal Role of Top-Down Theta Oscillations in Prioritization

Working Memory Epilepsy

Purpose: The purpose of this pilot study is to investigate the dynamics between theta and alpha oscillations in the control of working memory. These findings will be informative of what types of brain stimulation are most effective at modulating brain activity. Deep brain stimulation and transcranial magnetic stimulation are used for an increasing number of neurological and psychiatric disorders. Participants: Eligible participants are patients who have previously had electrodes implanted to monitor epilepsy (outside of research activity). 50 participants will be recruited, 25 participants for each phase of the study. Procedures (methods): The participants will perform a cognitive control task. During the task, rhythmic trains of direct cortical stimulation will be delivered to the frontal cortex alone or to the frontal and parietal cortex. Electrocorticography will be collected concurrent with stimulation.

Начало: 01.07.2024 Край: 31.01.2027 Възраст: 18–80 г.

United States University of North Carolina, Chapel Hill NCT06252532

1 … 4 5 6 7 8 … 240